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NDST2 N-deacetylase and N-sulfotransferase 2 [ Homo sapiens (human) ]

Gene ID: 8509, updated on 5-Mar-2024

Summary

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Official Symbol
NDST2provided by HGNC
Official Full Name
N-deacetylase and N-sulfotransferase 2provided by HGNC
Primary source
HGNC:HGNC:7681
See related
Ensembl:ENSG00000166507 MIM:603268; AllianceGenome:HGNC:7681
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
NST2; HSST2; N-HSST 2
Summary
This gene encodes a member of the N-deacetylase/N-sulfotransferase subfamily of the sulfotransferase 1 proteins. The encoded enzyme has dual functions in processing glucosamine and heparin polymers, including N-deacetylation and N-sulfation. The encoded protein may be localized to the Golgi. [provided by RefSeq, Feb 2009]
Expression
Ubiquitous expression in spleen (RPKM 13.3), bone marrow (RPKM 9.9) and 25 other tissues See more
Orthologs
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Genomic context

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See NDST2 in Genome Data Viewer
Location:
10q22.2
Exon count:
15
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 10 NC_000010.11 (73801916..73811820, complement)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 10 NC_060934.1 (74673316..74683220, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 10 NC_000010.10 (75561674..75571578, complement)

Chromosome 10 - NC_000010.11Genomic Context describing neighboring genes Neighboring gene ATAC-STARR-seq lymphoblastoid active region 3575 Neighboring gene ReSE screen-validated silencer GRCh37_chr10:75543706-75543880 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 3576 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 2488 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr10:75548316-75549515 Neighboring gene NDST2-ZSWIM8-AS1 readthrough Neighboring gene coiled-coil-helix-coiled-coil-helix domain containing 1 Neighboring gene zinc finger SWIM-type containing 8 Neighboring gene ZSWIM8 antisense RNA 1 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 2489 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 2490 Neighboring gene ReSE screen-validated silencer GRCh37_chr10:75574449-75574702 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:75579102-75579602 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:75579603-75580103 Neighboring gene calcium/calmodulin dependent protein kinase II gamma Neighboring gene MPRA-validated peak1013 silencer Neighboring gene H3K27ac hESC enhancer GRCh37_chr10:75617818-75618318 Neighboring gene H3K27ac hESC enhancer GRCh37_chr10:75618319-75618819 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 3577 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 2491 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 2492 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 2493 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 2494 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 3578 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 3579 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 3580 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr10:75646944-75648143 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr10:75648172-75649130 Neighboring gene uncharacterized LOC124902454

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Characterization of the N-deacetylase domain from the heparan sulfate N-deacetylase/N-sulfotransferase 2. Duncan MB, et al. Biochem Biophys Res Commun, 2006 Jan 27. PMID 16343444
  2. Endothelial inflammation: the role of differential expression of N-deacetylase/N-sulphotransferase enzymes in alteration of the immunological properties of heparan sulphate. Carter NM, et al. J Cell Sci, 2003 Sep 1. PMID 12876215
  3. Influence of high glucose concentrations on the expression of glycosaminoglycans and N-deacetylase/N-sulphotransferase mRNA in cultured skin fibroblasts from diabetic patients with or without nephropathy. Yard B, et al. Nephrol Dial Transplant, 2002 Mar. PMID 11865082
  4. cDNA cloning, genomic organization and chromosomal localization of human heparan glucosaminyl N-deacetylase/N-sulphotransferase-2. Humphries DE, et al. Biochem J, 1998 Jun 1. PMID 9601056, Free PMC Article
  5. Order out of chaos: assembly of ligand binding sites in heparan sulfate. Esko JD, et al. Annu Rev Biochem, 2002. PMID 12045103

See all (17) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Observational study of gene-disease association. (HuGE Navigator)
    Title: A scan of chromosome 10 identifies a novel locus showing strong association with late-onset Alzheimer disease.
Submit: New GeneRIF Correction

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Readthrough NDST2-ZSWIM8-AS1

Readthrough gene: NDST2-ZSWIM8-AS1, Included gene: ZSWIM8-AS1

Homology

Clone Names

  • MGC129697, MGC129705

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables N-acetylglucosamine deacetylase activity TAS
Traceable Author Statement
more info
  
enables [heparan sulfate]-glucosamine N-sulfotransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables [heparan sulfate]-glucosamine N-sulfotransferase activity TAS
Traceable Author Statement
more info
  
enables deacetylase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables heparan sulfate N-deacetylase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in heparan sulfate proteoglycan biosynthetic process, enzymatic modification TAS
Traceable Author Statement
more info
  
involved_in heparan sulfate proteoglycan biosynthetic process, polysaccharide chain biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in heparin biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
involved_in mast cell mediated immunity IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of angiotensin levels in blood IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in Golgi apparatus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in Golgi membrane TAS
Traceable Author Statement
more info
  
located_in membrane TAS
Traceable Author Statement
more info
 PubMed 

General protein information

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Preferred Names
bifunctional heparan sulfate N-deacetylase/N-sulfotransferase 2
Names
N-deacetylase/N-sulfotransferase (heparan glucosaminyl) 2
N-heparan sulfate sulfotransferase 2
glucosaminyl N-deacetylase/N-sulfotransferase 2
NP_001317036.1
NP_003626.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_046905.1 RefSeqGene

    Range
    5234..14916
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001330107.2 → NP_001317036.1  bifunctional heparan sulfate N-deacetylase/N-sulfotransferase 2 isoform 2

    Status: REVIEWED

    Source sequence(s)
    AC022400, AL045074, AU125430, BC035711, CN266932, DN999958
    Consensus CDS
    CCDS81476.1
    UniProtKB/TrEMBL
    B4E139, S4R438
    Conserved Domains (2) summary
    pfam00685
    Location:603 → 797
    Sulfotransfer_1; Sulfotransferase domain
    pfam12062
    Location:25 → 514
    HSNSD; heparan sulfate-N-deacetylase

  2. NM_003635.4 → NP_003626.1  bifunctional heparan sulfate N-deacetylase/N-sulfotransferase 2 isoform 1

    See identical proteins and their annotated locations for NP_003626.1

    Status: REVIEWED

    Source sequence(s)
    AK303648, BC035711
    Consensus CDS
    CCDS7335.1
    UniProtKB/Swiss-Prot
    P52849, Q2TB32, Q59H89
    UniProtKB/TrEMBL
    B4E139
    Related
    ENSP00000310657.6, ENST00000309979.11
    Conserved Domains (2) summary
    pfam00685
    Location:603 → 852
    Sulfotransfer_1; Sulfotransferase domain
    pfam12062
    Location:25 → 514
    HSNSD; heparan sulfate-N-deacetylase

RNA

  1. NR_160743.1 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AC022400

  2. NR_160744.1 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AC022400

  3. NR_160745.1 RNA Sequence

    Status: REVIEWED

    Description
    Transcript Variant: This variant (5) is represented as non-coding because it lacks the coding region found in variant 1.
    Source sequence(s)
    AC022400, AK303648, BC018681
    Related
    ENST00000398701.2

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000010.11 Reference GRCh38.p14 Primary Assembly

    Range
    73801916..73811820 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060934.1 Alternate T2T-CHM13v2.0

    Range
    74673316..74683220 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P52849.1 GenPept UniProtKB/Swiss-Prot:P52849

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