U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

TUB4 gamma-tubulin [ Saccharomyces cerevisiae S288C ]

Gene ID: 850909, updated on 17-May-2024

Summary

Go to the top of the page Help
Gene symbol
TUB4
Gene description
gamma-tubulin
Primary source
FungiDB:YLR212C
Locus tag
YLR212C
See related
SGD:S000004202; AllianceGenome:SGD:S000004202; VEuPathDB:YLR212C
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary
A structural constituent of cytoskeleton. Involved in microtubule nucleation by spindle pole body; mitotic spindle organization; and positive regulation of cytoplasmic translation. Located in inner plaque of spindle pole body and outer plaque of spindle pole body. Part of gamma-tubulin small complex. Used to study complex cortical dysplasia with other brain malformations 4. Human ortholog(s) of this gene implicated in complex cortical dysplasia with other brain malformations 4; inclusion body myositis; and muscular disease. Orthologous to several human genes including TUBG2 (tubulin gamma 2). [provided by Alliance of Genome Resources, Apr 2022]
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
See TUB4 in Genome Data Viewer
Location:
chromosome: XII
Exon count:
1
Sequence:
Chromosome: XII; NC_001144.5 (564860..566281, complement)

Chromosome XII - NC_001144.5Genomic Context describing neighboring genes Neighboring gene B-type cyclin CLB4 Neighboring gene Atg38p Neighboring gene putative glycosylase Neighboring gene ferric/cupric-chelate reductase

Genomic regions, transcripts, and products

Go to the top of the page Help
Genomic Sequence:
NC_001144.5

Go to nucleotide: Graphics FASTA GenBank

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. Concerted millisecond timescale dynamics in the intrinsically disordered carboxyl terminus of γ-tubulin induced by mutation of a conserved tyrosine residue. Harris J, et al. Protein Sci, 2018 Feb. PMID 29127738, Free PMC Article
  2. Distinct roles for antiparallel microtubule pairing and overlap during early spindle assembly. Nazarova E, et al. Mol Biol Cell, 2013 Oct. PMID 23966467, Free PMC Article
  3. Mutations in TUBG1, DYNC1H1, KIF5C and KIF2A cause malformations of cortical development and microcephaly. Poirier K, et al. Nat Genet, 2013 Jun. PMID 23603762, Free PMC Article
  4. Phosphorylation of gamma-tubulin regulates microtubule organization in budding yeast. Vogel J, et al. Dev Cell, 2001 Nov. PMID 11709183
  5. Analysis of Tub4p, a yeast gamma-tubulin-like protein: implications for microtubule-organizing center function. Marschall LG, et al. J Cell Biol, 1996 Jul. PMID 8707828, Free PMC Article

See all (85) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. findings revealed that Rok1 protein synthesis is repressed by Psk2 and Skp1; this repression appeared to be mediated through the ROK1 uORF1; Tub4 plays a positive role in regulating Rok1 protein synthesis and likely after the uORF1-mediated inhibitory regulation
    Title: Identification of Psk2, Skp1, and Tub4 as trans-acting factors for uORF-containing ROK1 mRNA in Saccharomyces cerevisiae.
  2. The structure of the Saccharomyces cerevisiae gamma-tubulin small complex at 25-A resolution by electron microscopy, is determined.
    Title: The structure of the gamma-tubulin small complex: implications of its architecture and flexibility for microtubule nucleation.
  3. We propose that SPBs, via the tail of Tub4, promote the assembly of functional +TIP complexes before their deployment to microtubule +ends.
    Title: Gamma-tubulin is required for proper recruitment and assembly of Kar9-Bim1 complexes in budding yeast.
Submit: New GeneRIF Correction

Interactions

Go to the top of the page Help
Products Interactant Other Gene Complex Source Pubs Description

General gene information

Go to the top of the page Help

Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables GTP binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables GTP binding IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables structural constituent of cytoskeleton IBA
Inferred from Biological aspect of Ancestor
more info
  
enables structural constituent of cytoskeleton IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Process Evidence Code Pubs
involved_in cytoplasmic microtubule organization IEA
Inferred from Electronic Annotation
more info
  
involved_in meiotic spindle organization IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in microtubule nucleation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in microtubule nucleation IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in microtubule nucleation IEA
Inferred from Electronic Annotation
more info
  
involved_in microtubule nucleation by spindle pole body IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in microtubule-based process IEA
Inferred from Electronic Annotation
more info
  
involved_in mitotic cell cycle IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in mitotic sister chromatid segregation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in mitotic spindle organization IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in mitotic spindle organization IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in organelle organization IEA
Inferred from Electronic Annotation
more info
  
involved_in positive regulation of cytoplasmic translation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in cytoskeleton IEA
Inferred from Electronic Annotation
more info
  
part_of gamma-tubulin complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of gamma-tubulin complex IEA
Inferred from Electronic Annotation
more info
  
part_of gamma-tubulin small complex IDA
Inferred from Direct Assay
more info
 PubMed 
part_of gamma-tubulin small complex IPI
Inferred from Physical Interaction
more info
 PubMed 
located_in inner plaque of spindle pole body IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in microtubule IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in microtubule IEA
Inferred from Electronic Annotation
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in outer plaque of spindle pole body IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in spindle IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in spindle pole body HDA PubMed 
is_active_in spindle pole body IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in spindle pole body IEA
Inferred from Electronic Annotation
more info
  

General protein information

Go to the top of the page Help
Preferred Names
gamma-tubulin
NP_013313.1
  • Gamma-tubulin; involved in nucleating microtubules from both the cytoplasmic and nuclear faces of the spindle pole body; protein abundance increases in response to DNA replication stress; null mutation is complemented by human TUBG1

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001144.5 Reference assembly

    Range
    564860..566281 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001182099.1 → NP_013313.1  TPA: gamma-tubulin [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_013313.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6VYL3, P53378
    UniProtKB/TrEMBL
    A0A8H4BZN3, A7A1A0, B3RHA1, B5VND0, C7GIU1, C8ZDH6, G2WJ42, N1P6V4
    Conserved Domains (1) summary
    COG5023
    Location:2 → 456
    COG5023; Tubulin [Cytoskeleton]
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
7M2X_A.1
7M2X_B.1
7M2Y_A.1
7M2Y_B.1
7M2Z_A.1
7M2Z_B.1
P53378.1

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Other Literature Sources
Molecular Biology Databases
Research Materials
Tools