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COA4 Coa4p [ Saccharomyces cerevisiae S288C ]

Gene ID: 850915, updated on 17-May-2024

Summary

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Gene symbol
COA4
Gene description
Coa4p
Primary source
FungiDB:YLR218C
Locus tag
YLR218C
See related
SGD:S000004208; AllianceGenome:SGD:S000004208; VEuPathDB:YLR218C
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Also known as
CMC3
Summary
Involved in mitochondrial cytochrome c oxidase assembly. Located in mitochondrial intermembrane space. Orthologous to human COA4 (cytochrome c oxidase assembly factor 4 homolog). [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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See COA4 in Genome Data Viewer
Location:
chromosome: XII
Exon count:
1
Sequence:
Chromosome: XII; NC_001144.5 (573466..573918, complement)

Chromosome XII - NC_001144.5Genomic Context describing neighboring genes Neighboring gene cell proliferation protein CDC123 Neighboring gene peptidylprolyl isomerase CPR6 Neighboring gene Msc3p Neighboring gene Ccc1p

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001144.5

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. A yeast suppressor screen links Coa4 to the mitochondrial copper delivery pathway for cytochrome c oxidase. Swaminathan AB, et al. Genetics, 2022 Jul 30. PMID 35666203, Free PMC Article
  2. Inaccurately assembled cytochrome c oxidase can lead to oxidative stress-induced growth arrest. Bode M, et al. Antioxid Redox Signal, 2013 May 1. PMID 23198688, Free PMC Article
  3. Analysis of Leigh syndrome mutations in the yeast SURF1 homolog reveals a new member of the cytochrome oxidase assembly factor family. Bestwick M, et al. Mol Cell Biol, 2010 Sep. PMID 20624914, Free PMC Article
  4. Systematic screen for human disease genes in yeast. Steinmetz LM, et al. Nat Genet, 2002 Aug. PMID 12134146
  5. Systematic analysis of the twin cx(9)c protein family. Longen S, et al. J Mol Biol, 2009 Oct 23. PMID 19703468

See all (28) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables molecular_function ND
No biological Data available
more info
  
Process Evidence Code Pubs
involved_in mitochondrial cytochrome c oxidase assembly IEA
Inferred from Electronic Annotation
more info
  
involved_in mitochondrial cytochrome c oxidase assembly IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in mitochondrial cytochrome c oxidase assembly IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in mitochondrial respiratory chain complex assembly IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in cytoplasm HDA PubMed 
located_in mitochondrial inner membrane IEA
Inferred from Electronic Annotation
more info
  
is_active_in mitochondrial intermembrane space IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in mitochondrial intermembrane space IDA
Inferred from Direct Assay
more info
 PubMed 
located_in mitochondrial intermembrane space IEA
Inferred from Electronic Annotation
more info
  
located_in mitochondrion IEA
Inferred from Electronic Annotation
more info
  
located_in nucleus HDA PubMed 

General protein information

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Preferred Names
Coa4p
NP_013319.1
  • Twin Cx(9)C protein involved in cytochrome c oxidase organization; organization includes assembly or stability; localizes to the mitochondrial intermembrane space via the Mia40p-Erv1p system; interacts genetically with CYC1 and with cytochrome c oxidase assembly factors; mutation can be complemented by human COA4

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001144.5 Reference assembly

    Range
    573466..573918 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001182105.1 → NP_013319.1  TPA: Coa4p [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_013319.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A8H4BXB8, A7A1A5, B3RHA6, C7GIU6, C8ZDI2, N1NZU5
Nucleotide Protein
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