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GPN3 putative signal sequence-binding GTPase GPN3 [ Saccharomyces cerevisiae S288C ]

Gene ID: 850944, updated on 18-Sep-2024

Summary

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Official Symbol
GPN3
Official Full Name
putative signal sequence-binding GTPase GPN3
Primary source
SGD:S000004233
Locus tag
YLR243W
See related
AllianceGenome:SGD:S000004233; FungiDB:YLR243W; VEuPathDB:YLR243W
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary
Predicted to enable GTPase activity. Involved in mitotic sister chromatid cohesion and protein import into nucleus. Orthologous to human GPN3 (GPN-loop GTPase 3). [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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See GPN3 in Genome Data Viewer
Location:
chromosome: XII
Exon count:
1
Sequence:
Chromosome: XII; NC_001144.5 (624203..625021)

Chromosome XII - NC_001144.5Genomic Context describing neighboring genes Neighboring gene Csc1p Neighboring gene sterol homeostasis protein ARV1 Neighboring gene methionine aminopeptidase MAP1 Neighboring gene cytidine deaminase

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001144.5

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Gpn2 and Rba50 Directly Participate in the Assembly of the Rpb3 Subcomplex in the Biogenesis of RNA Polymerase II. Zeng F, et al. Mol Cell Biol, 2018 Jul 1. PMID 29661922, Free PMC Article
  2. Biogenesis of RNA polymerases II and III requires the conserved GPN small GTPases in Saccharomyces cerevisiae. Minaker SW, et al. Genetics, 2013 Mar. PMID 23267056, Free PMC Article
  3. Npa3 interacts with Gpn3 and assembly factor Rba50 for RNA polymerase II biogenesis. Liu X, et al. FASEB J, 2020 Nov. PMID 32985767
  4. Eukaryotic GPN-loop GTPases paralogs use a dimeric assembly reminiscent of archeal GPN. Alonso B, et al. Cell Cycle, 2013 Feb 1. PMID 23324351, Free PMC Article
  5. A nuclear proteome localization screen reveals the exquisite specificity of Gpn2 in RNA polymerase biogenesis. Minaker SW, et al. Cell Cycle, 2021 Jul. PMID 34180355, Free PMC Article

See all (34) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. The results suggest that the GPN proteins (GPN2 and GPN3) function upstream of Iwr1 in RNA polymerase II and III biogenesis.
    Title: Biogenesis of RNA polymerases II and III requires the conserved GPN small GTPases in Saccharomyces cerevisiae.
  2. These results suggest that yGPN1 and yGPN2, yGPN3 proteins act at the molecular level in sister chromatid cohesion mechanism as a GPN|GPN complex.
    Title: Eukaryotic GPN-loop GTPases paralogs use a dimeric assembly reminiscent of archeal GPN.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables GTP binding IEA
Inferred from Electronic Annotation
more info
  
enables GTPase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables GTPase activity ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in mitotic sister chromatid cohesion IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in protein import into nucleus IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
is_active_in cellular_component ND
No biological Data available
more info
  

General protein information

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Preferred Names
putative signal sequence-binding GTPase GPN3
NP_013344.1
  • Putative GTPase with a role in biogenesis of RNA pol II and polIII; may be involved in assembly of RNA polymerases II and III and in their transport into the nucleus; may have a role in sister chromatid cohesion; SWAT-GFP and mCherry fusion proteins localize to the endoplasmic reticulum and vacuole respectively; contains a Gly-Pro-Asn motif in the G domain; similar to Npa3p and Gpn2p

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001144.5 Reference assembly

    Range
    624203..625021
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001182130.1 → NP_013344.1  TPA: putative signal sequence-binding GTPase GPN3 [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_013344.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6VYP1, Q06543
    UniProtKB/TrEMBL
    A7A1C6, B3RHC8, B5VNG0, C7GQZ3, C8ZDK6, G2WJ69, N1NZG7
    Conserved Domains (1) summary
    cd17872
    Location:5 → 251
    GPN3; GPN-loop GTPase 3
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q06543.1

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