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HAP1 Hap1p [ Saccharomyces cerevisiae S288C ]

Gene ID: 850958, updated on 29-Jun-2024

Summary

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Gene symbol
HAP1
Gene description
Hap1p
Primary source
FungiDB:YLR256W
Locus tag
YLR256W
See related
SGD:S000004246; AllianceGenome:SGD:S000004246; VEuPathDB:YLR256W
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Also known as
CYP1
Summary
Enables DNA-binding transcription activator activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Involved in establishment of protein localization to chromatin; regulation of cellular respiration; and regulation of transcription by RNA polymerase II. Located in mitochondrion and nucleus. [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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See HAP1 in Genome Data Viewer
Location:
chromosome: XII
Exon count:
1
Sequence:
Chromosome: XII; NC_001144.5 (646415..650923)

Chromosome XII - NC_001144.5Genomic Context describing neighboring genes Neighboring gene Ndl1p Neighboring gene uncharacterized protein Neighboring gene gag protein Neighboring gene tRNA-Ala

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001144.5

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Heme metabolism in stress regulation and protein production: From Cinderella to a key player. Martínez JL, et al. Bioengineered, 2016 Apr 2. PMID 26731643, Free PMC Article
  2. A hap1 mutation in a laboratory strain of Saccharomyces cerevisiae results in decreased expression of ergosterol-related genes and cellular ergosterol content compared to sake yeast. Tamura K, et al. J Biosci Bioeng, 2004. PMID 16233684
  3. The heme activator protein Hap1 represses transcription by a heme-independent mechanism in Saccharomyces cerevisiae. Hon T, et al. Genetics, 2005 Mar. PMID 15654089, Free PMC Article
  4. Control of Hap1-DNA site recognition through the interplay of multiple distinct intermolecular interactions. Wang LL, et al. Biochemistry, 2004 Nov 2. PMID 15504044
  5. The coiled coil dimerization element of the yeast transcriptional activator Hap1, a Gal4 family member, is dispensable for DNA binding but differentially affects transcriptional activation. Hach A, et al. J Biol Chem, 2000 Jan 7. PMID 10617612

See all (96) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. The activator/repressor Hap1 binds to the yeast eIF5A-encoding gene TIF51A to adapt its expression to the mitochondrial functional status.
    Title: The activator/repressor Hap1 binds to the yeast eIF5A-encoding gene TIF51A to adapt its expression to the mitochondrial functional status.
  2. Hap1 also plays a significant and direct role under hypoxic conditions, not as an activator, but as a repressor.
    Title: Heme levels switch the function of Hap1 of Saccharomyces cerevisiae between transcriptional activator and transcriptional repressor.
  3. analysis of a complex mechanism of transcriptional regulation at the HAP1 promoter, involving multiple DNA elements and regulatory proteins
    Title: Regulation of the HAP1 gene involves positive actions of histone deacetylases.
  4. Hap1 binds to DNA and activates transcription of genes encoding functions required for respiration and for controlling oxidative damage.
    Title: The heme activator protein Hap1 represses transcription by a heme-independent mechanism in Saccharomyces cerevisiae.
  5. A simultaneous optimization of distinct intermolecular interactions determines the DNA-binding specificity of Hap1. Perturbations to individual interactions modulate Hap1 binding affinity and, very likely, its binding geometry.
    Title: Control of Hap1-DNA site recognition through the interplay of multiple distinct intermolecular interactions.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables DNA binding IEA
Inferred from Electronic Annotation
more info
  
enables DNA-binding transcription activator activity, RNA polymerase II-specific IBA
Inferred from Biological aspect of Ancestor
more info
  
enables DNA-binding transcription activator activity, RNA polymerase II-specific IDA
Inferred from Direct Assay
more info
 PubMed 
enables DNA-binding transcription activator activity, RNA polymerase II-specific IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables DNA-binding transcription factor activity, RNA polymerase II-specific IEA
Inferred from Electronic Annotation
more info
  
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables sequence-specific DNA binding HDA PubMed 
enables zinc ion binding IEA
Inferred from Electronic Annotation
more info
  
enables zinc ion binding RCA
inferred from Reviewed Computational Analysis
more info
 PubMed 
Process Evidence Code Pubs
involved_in DNA-templated transcription IEA
Inferred from Electronic Annotation
more info
  
involved_in carbon catabolite activation of transcription from RNA polymerase II promoter IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in cellular response to hypoxia IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in establishment of protein localization to chromatin IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in negative regulation of transcription by RNA polymerase II IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of transcription by RNA polymerase II IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of DNA-templated transcription IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of cellular respiration IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in regulation of cellular respiration IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in mitochondrion IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
Hap1p
NP_013357.1
  • Zinc finger transcription factor; involved in the complex regulation of gene expression in response to levels of heme and oxygen; localizes to the mitochondrion as well as to the nucleus; the S288C sequence differs from other strain backgrounds due to a Ty1 insertion in the carboxy terminus

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001144.5 Reference assembly

    Range
    646415..650923
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001182143.1 → NP_013357.1  TPA: Hap1p [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_013357.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6VYQ2, P0CE41, P0CS82
    UniProtKB/TrEMBL
    A0A8H4F8Q7
    Conserved Domains (3) summary
    cd12148
    Location:476 → 814
    fungal_TF_MHR; fungal transcription factor regulatory middle homology region
    smart00066
    Location:59 → 99
    GAL4; GAL4-like Zn(II)2Cys6 (or C6 zinc) binuclear cluster DNA-binding domain
    cd14655
    Location:99 → 130
    ZIP_Hap1; Leucine zipper Dimerization domain of transcription factor Hap1 and similar fungal proteins
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P0CE41.1

Gene LinkOut

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