RED1 Red1p [Saccharomyces cerevisiae S288C] - Gene

Summary

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Official Symbol: RED1
Official Full Name: Red1p
Primary source: SGD:S000004253
Locus tag: YLR263W
See related: AllianceGenome:SGD:S000004253; FungiDB:YLR263W; VEuPathDB:YLR263W
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Saccharomyces cerevisiae S288C (strain: S288C)
Lineage: Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary: Enables chromatin DNA binding activity and structural molecule activity. Involved in meiotic recombination checkpoint signaling; positive regulation of catalytic activity; and synaptonemal complex assembly. Located in lateral element. [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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See RED1 in Genome Data Viewer

Location:: chromosome: XII

Exon count:: 1

Sequence:: Chromosome: XII; NC_001144.5 (670340..672823)

Chromosome XII - NC_001144.5 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_001144.5

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

How do small chromosomes know they are small? Maximizing meiotic break formation on the shortest yeast chromosomes.
Title: How do small chromosomes know they are small? Maximizing meiotic break formation on the shortest yeast chromosomes.
Data show that Hop1 protein possesses conformational dynamics similar to spindle checkpoint protein MAD2 (Mad2), and identify closure motifs in the Hop1 binding partner Red1 protein.
Title: Conformational dynamics of the Hop1 HORMA domain reveal a common mechanism with the spindle checkpoint protein Mad2.
These localization patterns closely tracked the distribution of Red1 and Hop1, axis proteins required for Mek1 activation. These findings provide insight into the spatial disposition of Mek1 kinase activity and the higher order organization of recombining meiotic chromosomes
Title: Histone H3 Threonine 11 Phosphorylation Is Catalyzed Directly by the Meiosis-Specific Kinase Mek1 and Provides a Molecular Readout of Mek1 Activity in Vivo.
selective loss of checkpoint function is supported by a RED1 dosage series and is associated with the loss of most of the cytologically detectable Red1 from the axial element. Our results indicate separable roles for Red1 in building the structural axis of meiotic chromosomes and mounting a sustained recombination checkpoint response
Title: Reduced dosage of the chromosome axis factor Red1 selectively disrupts the meiotic recombination checkpoint in Saccharomyces cerevisiae.
The phosphorylation of Red1 is not essential for Red1's functions in meiosis.
Title: Genetic requirements and meiotic function of phosphorylation of the yeast axial element protein Red1.
Red1, in addition to its structural role in the SC, is a crucial coordinator of meiosis by coupling checkpoint signaling to SC formation
Title: Synaptonemal complex formation and meiotic checkpoint signaling are linked to the lateral element protein Red1.
Red1 binds SUMO chains to promote meiotic interhomologue recombination and chromosome synapsis.
Title: Yeast axial-element protein, Red1, binds SUMO chains to promote meiotic interhomologue recombination and chromosome synapsis.
Localization of Zip1, Hop1, and Red1 along meiotic chromosomes in WT and pch2 meiosis
Title: Yeast Pch2 promotes domainal axis organization, timely recombination progression, and arrest of defective recombinosomes during meiosis.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

Orthologs from OrthoDB

Gene Ontology Provided by SGD

Function	Evidence Code	Pubs
enables chromatin DNA binding	IDA Inferred from Direct Assay more info	PubMed
enables structural molecule activity	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
involved_in meiotic cell cycle	IEA Inferred from Electronic Annotation more info
involved_in meiotic recombination checkpoint signaling	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in reciprocal meiotic recombination	IEA Inferred from Electronic Annotation more info
involved_in sporulation resulting in formation of a cellular spore	IEA Inferred from Electronic Annotation more info
involved_in synaptonemal complex assembly	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in lateral element	IDA Inferred from Direct Assay more info	PubMed
located_in nucleus	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: Red1p

NP_013365.1

Protein component of the synaptonemal complex axial elements; involved in chromosome segregation during the first meiotic division; critical for coupling checkpoint signaling to SC formation; promotes interhomolog recombination by phosphorylating Hop1p; also interacts with Mec3p and Ddc1p