U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

SMD2 mRNA splicing protein SMD2 [ Saccharomyces cerevisiae S288C ]

Gene ID: 850981, updated on 18-Sep-2024

Summary

Go to the top of the page Help
Official Symbol
SMD2
Official Full Name
mRNA splicing protein SMD2
Primary source
SGD:S000004265
Locus tag
YLR275W
See related
AllianceGenome:SGD:S000004265; FungiDB:YLR275W; VEuPathDB:YLR275W
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary
Predicted to enable RNA binding activity. Predicted to be involved in spliceosomal snRNP assembly. Part of U2-type prespliceosome and spliceosomal snRNP complex. Human ortholog(s) of this gene implicated in systemic lupus erythematosus. Orthologous to human SNRPD2 (small nuclear ribonucleoprotein D2 polypeptide). [provided by Alliance of Genome Resources, Apr 2022]
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
See SMD2 in Genome Data Viewer
Location:
chromosome: XII
Exon count:
2
Sequence:
Chromosome: XII; NC_001144.5 (694378..694800)

Chromosome XII - NC_001144.5Genomic Context describing neighboring genes Neighboring gene protein phosphatase regulator PIG1 Neighboring gene MCM DNA helicase complex subunit MCM5 Neighboring gene ATP-dependent DNA/RNA helicase Neighboring gene cleavage polyadenylation factor subunit YSH1

Genomic regions, transcripts, and products

Go to the top of the page Help
Genomic Sequence:
NC_001144.5

Go to nucleotide: Graphics FASTA GenBank

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. QTL analysis of high thermotolerance with superior and downgraded parental yeast strains reveals new minor QTLs and converges on novel causative alleles involved in RNA processing. Yang Y, et al. PLoS Genet, 2013. PMID 23966873, Free PMC Article
  2. Partial purification of the yeast U2 snRNP reveals a novel yeast pre-mRNA splicing factor required for pre-spliceosome assembly. Caspary F, et al. EMBO J, 1999 Jun 15. PMID 10369685, Free PMC Article
  3. Functional characterization of nuclear localization signals in yeast Sm proteins. Bordonné R. Mol Cell Biol, 2000 Nov. PMID 11027265, Free PMC Article
  4. Stoichiometry of the Sm proteins in yeast spliceosomal snRNPs supports the heptamer ring model of the core domain. Walke S, et al. J Mol Biol, 2001 Apr 20. PMID 11302706
  5. Identification of the proteins of the yeast U1 small nuclear ribonucleoprotein complex by mass spectrometry. Neubauer G, et al. Proc Natl Acad Sci U S A, 1997 Jan 21. PMID 9012791, Free PMC Article

See all (69) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

Go to the top of the page

Interactions

Go to the top of the page Help
Products Interactant Other Gene Complex Source Pubs Description

General gene information

Go to the top of the page Help

Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables RNA binding IEA
Inferred from Electronic Annotation
more info
  
enables molecular_function ND
No biological Data available
more info
  
Process Evidence Code Pubs
involved_in RNA splicing IEA
Inferred from Electronic Annotation
more info
  
involved_in biological_process ND
No biological Data available
more info
  
involved_in mRNA processing IEA
Inferred from Electronic Annotation
more info
  
involved_in spliceosomal snRNP assembly IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
part_of U1 snRNP IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of U1 snRNP IDA
Inferred from Direct Assay
more info
 PubMed 
part_of U2 snRNP IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of U2-type prespliceosome IDA
Inferred from Direct Assay
more info
 PubMed 
part_of U4/U6 x U5 tri-snRNP complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of U4/U6 x U5 tri-snRNP complex IDA
Inferred from Direct Assay
more info
 PubMed 
part_of U5 snRNP IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of U5 snRNP IDA
Inferred from Direct Assay
more info
 PubMed 
part_of catalytic step 2 spliceosome IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in cytosol IEA
Inferred from Electronic Annotation
more info
  
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  
part_of pICln-Sm protein complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of precatalytic spliceosome IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of protein-containing complex IEA
Inferred from Electronic Annotation
more info
  
part_of ribonucleoprotein complex IEA
Inferred from Electronic Annotation
more info
  
part_of small nuclear ribonucleoprotein complex IEA
Inferred from Electronic Annotation
more info
  

General protein information

Go to the top of the page Help
Preferred Names
mRNA splicing protein SMD2
NP_013377.1
  • Core Sm protein Sm D2; part of heteroheptameric complex (with Smb1p, Smd1p, Smd3p, Sme1p, Smx3p, and Smx2p) that is part of the spliceosomal U1, U2, U4, and U5 snRNPs; homolog of human Sm D2

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001144.5 Reference assembly

    Range
    694378..694800
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001182162.1 → NP_013377.1  TPA: mRNA splicing protein SMD2 [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_013377.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6VYS2, Q06217
    UniProtKB/TrEMBL
    A7A1F9, B3RHF7, C8ZDN9, G2WJA1
    Conserved Domains (1) summary
    cd01720
    Location:27 → 108
    Sm_D2; Sm protein D2
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q06217.2

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Other Literature Sources
Molecular Biology Databases
Research Materials
Tools