U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

MEC3 Mec3p [ Saccharomyces cerevisiae S288C ]

Gene ID: 850995, updated on 3-Nov-2024

Summary

Go to the top of the page Help
Official Symbol
MEC3
Official Full Name
Mec3p
Primary source
SGD:S000004279
Locus tag
YLR288C
See related
AllianceGenome:SGD:S000004279; FungiDB:YLR288C; VEuPathDB:YLR288C
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Also known as
PIP3; PSO9
Summary
Enables DNA binding activity. Involved in DNA damage checkpoint signaling; subtelomeric heterochromatin formation; and telomere maintenance via recombination. Part of checkpoint clamp complex. [provided by Alliance of Genome Resources, Nov 2024]
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
See MEC3 in Genome Data Viewer
Location:
chromosome: XII
Exon count:
1
Sequence:
Chromosome: XII; NC_001144.5 (713480..714904, complement)

Chromosome XII - NC_001144.5Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene ribosomal 40S subunit protein S30A Neighboring gene GTPase GUF1 Neighboring gene ubiquinone biosynthesis protein COQ11

Genomic regions, transcripts, and products

Go to the top of the page Help
Genomic Sequence:
NC_001144.5

Go to nucleotide: Graphics FASTA GenBank

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. DNA damage checkpoint in budding yeast. Longhese MP, et al. EMBO J, 1998 Oct 1. PMID 9755152, Free PMC Article
  2. DNA damage checkpoints and DNA replication controls in Saccharomyces cerevisiae. Foiani M, et al. Mutat Res, 2000 Jun 30. PMID 10915872
  3. Dual cell cycle checkpoints sensitive to chromosome replication and DNA damage in the budding yeast Saccharomyces cerevisiae. Weinert TA. Radiat Res, 1992 Nov. PMID 1438694
  4. Yeast checkpoint genes in DNA damage processing: implications for repair and arrest. Lydall D, et al. Science, 1995 Dec 1. PMID 7491494
  5. Psoralen-sensitive mutant pso9-1 of Saccharomyces cerevisiae contains a mutant allele of the DNA damage checkpoint gene MEC3. Cardone JM, et al. DNA Repair (Amst), 2006 Feb 3. PMID 16202664

See all (129) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. a Ddc1-Mec3-Rad17 sliding clamp has a role in regulating histone-histone chaperone interactions and DNA replication-coupled nucleosome assembly in budding yeast
    Title: The Ddc1-Mec3-Rad17 sliding clamp regulates histone-histone chaperone interactions and DNA replication-coupled nucleosome assembly in budding yeast.
  2. Control of telomeric recombination by Mec3.
    Title: Control of the yeast telomeric senescence survival pathways of recombination by the Mec1 and Mec3 DNA damage sensors and RPA.
  3. Overexpression of MEC3 in a DDC1Delta strain shows no rescue of DNA damage sensitivity.
    Title: Function of Rad17/Mec3/Ddc1 and its partial complexes in the DNA damage checkpoint.
  4. a mutant allele of the DNA damage checkpoint gene MEC3 is in Psoralen-sensitive mutant pso9-1 of Saccharomyces cerevisiae
    Title: Psoralen-sensitive mutant pso9-1 of Saccharomyces cerevisiae contains a mutant allele of the DNA damage checkpoint gene MEC3.
  5. the 9-1-1 clamp, made of Ddc1, Rad17, and Mec3, may physically regulate Polzeta-dependent mutagenesis by controlling the access of Polzeta to damaged DNA
    Title: The 9-1-1 checkpoint clamp physically interacts with polzeta and is partially required for spontaneous polzeta-dependent mutagenesis in Saccharomyces cerevisiae.
Submit: New GeneRIF Correction

Pathways from PubChem

Go to the top of the page

Interactions

Go to the top of the page Help
Products Interactant Other Gene Complex Source Pubs Description

General gene information

Go to the top of the page Help

Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables DNA binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables DNA binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in DNA damage checkpoint signaling IEA
Inferred from Electronic Annotation
more info
  
involved_in DNA damage checkpoint signaling IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in DNA repair IEA
Inferred from Electronic Annotation
more info
  
involved_in double-strand break repair via homologous recombination IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in meiotic DNA integrity checkpoint signaling IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in mitotic DNA replication checkpoint signaling IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in mitotic intra-S DNA damage checkpoint signaling IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in nucleotide-excision repair IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in subtelomeric heterochromatin formation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in telomere maintenance IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in telomere maintenance via recombination IGI
Inferred from Genetic Interaction
more info
 PubMed 
Component Evidence Code Pubs
part_of checkpoint clamp complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of checkpoint clamp complex IDA
Inferred from Direct Assay
more info
 PubMed 
part_of checkpoint clamp complex IEA
Inferred from Electronic Annotation
more info
  
located_in chromosome, telomeric region IEA
Inferred from Electronic Annotation
more info
  
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  
is_active_in site of double-strand break IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

Go to the top of the page Help
Preferred Names
Mec3p
NP_013391.1
  • DNA damage and meiotic pachytene checkpoint protein; subunit of a heterotrimeric complex (Rad17p-Mec3p-Ddc1p) that forms a sliding clamp, loaded onto partial duplex DNA by a clamp loader complex; homolog of human and S. pombe Hus1

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001144.5 Reference assembly

    Range
    713480..714904 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001182176.1 → NP_013391.1  TPA: Mec3p [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_013391.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6VYT4, P87260, Q02574, Q05887
    UniProtKB/TrEMBL
    C7GVU9, G2WJB2, N1NZJ9
    Conserved Domains (1) summary
    pfam04005
    Location:1 → 468
    Hus1; Hus1-like protein
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q02574.3

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Other Literature Sources
Molecular Biology Databases
Research Materials
Tools
Miscellaneous