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CDC3 septin CDC3 [ Saccharomyces cerevisiae S288C ]

Gene ID: 851024, updated on 28-Oct-2024

Summary

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Official Symbol
CDC3
Official Full Name
septin CDC3
Primary source
SGD:S000004306
Locus tag
YLR314C
See related
AllianceGenome:SGD:S000004306; FungiDB:YLR314C; VEuPathDB:YLR314C
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary
Enables GTP binding activity; phosphatidylinositol-4-phosphate binding activity; and phosphatidylinositol-5-phosphate binding activity. A structural constituent of cytoskeleton. Involved in mitotic cytokinesis; septin ring assembly; and septin ring disassembly. Located in several cellular components, including mating projection base; prospore membrane; and septin cytoskeleton. Part of septin complex. Orthologous to several human genes including SEPTIN7 (septin 7). [provided by Alliance of Genome Resources, Oct 2024]
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Genomic context

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See CDC3 in Genome Data Viewer
Location:
chromosome: XII
Exon count:
1
Sequence:
Chromosome: XII; NC_001144.5 (762575..764137, complement)

Chromosome XII - NC_001144.5Genomic Context describing neighboring genes Neighboring gene mitochondrial 54S ribosomal protein YmL15 Neighboring gene Sph1p Neighboring gene Nkp2p Neighboring gene Tad3p Neighboring gene telomerase reverse transcriptase

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001144.5

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Endosomal transport of septin mRNA and protein indicates local translation on endosomes and is required for correct septin filamentation. Baumann S, et al. EMBO Rep, 2014 Jan. PMID 24355572, Free PMC Article
  2. Tension modulates actin filament polymerization mediated by formin and profilin. Courtemanche N, et al. Proc Natl Acad Sci U S A, 2013 Jun 11. PMID 23716666, Free PMC Article
  3. Septin filaments exhibit a dynamic, paired organization that is conserved from yeast to mammals. DeMay BS, et al. J Cell Biol, 2011 Jun 13. PMID 21670216, Free PMC Article
  4. Formation of septum-like structures at locations remote from the budding sites in cytokinesis-defective mutants of Saccharomyces cerevisiae. Slater ML, et al. J Bacteriol, 1985 May. PMID 3886632, Free PMC Article
  5. Structural insights into yeast septin organization from polarized fluorescence microscopy. Vrabioiu AM, et al. Nature, 2006 Sep 28. PMID 17006515

See all (171) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Local mRNA translation loads endosomes with Cdc3 for assembly and efficient delivery to septin filaments.
    Title: Endosomal transport of septin mRNA and protein indicates local translation on endosomes and is required for correct septin filamentation.
  2. Data indicate that small forces on the filaments dramatically slowed formin Bni1p-mediated polymerization in the absence of profilin, but resulted in faster polymerization in the presence of profilin.
    Title: Tension modulates actin filament polymerization mediated by formin and profilin.
  3. Both the hourglass and ring filament assemblies have sub-resolution C(2) symmetry and lack net polarity along the mother-daughter axis.
    Title: Symmetry of septin hourglass and ring structures.
  4. during cytokinesis septin rings, located on both sides of the actomyosin ring, acted as barriers to compartmentalize the cortex around the cleavage site
    Title: Spatial coordination of cytokinetic events by compartmentalization of the cell cortex.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables GTP binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables GTP binding IEA
Inferred from Electronic Annotation
more info
  
enables GTPase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables molecular adaptor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables phosphatidylinositol-4-phosphate binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables phosphatidylinositol-5-phosphate binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables structural constituent of cytoskeleton IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
involved_in cell division IEA
Inferred from Electronic Annotation
more info
  
involved_in cytoskeleton-dependent cytokinesis IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in mitotic cytokinesis IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in mitotic cytokinesis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in protein localization IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in septin ring assembly IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in septin ring disassembly IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in ascospore wall IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in cell division site IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cellular bud neck HDA PubMed 
located_in cellular bud neck IEA
Inferred from Electronic Annotation
more info
  
located_in cellular bud neck septin ring IDA
Inferred from Direct Assay
more info
 PubMed 
located_in mating projection base IDA
Inferred from Direct Assay
more info
 PubMed 
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
is_active_in microtubule cytoskeleton IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in prospore membrane IDA
Inferred from Direct Assay
more info
 PubMed 
part_of septin complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of septin complex IDA
Inferred from Direct Assay
more info
 PubMed 
part_of septin complex IEA
Inferred from Electronic Annotation
more info
  
part_of septin complex IPI
Inferred from Physical Interaction
more info
 PubMed 
located_in septin filament array IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in septin ring IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
septin CDC3
NP_013418.2
  • Component of the septin ring that is required for cytokinesis; septins are GTP-binding proteins that assemble with other septins into rod-like complexes that can associate with other rods to form filament polymers; septin rings at the mother-bud neck act as scaffolds for recruiting factors needed for cell division and as barriers to prevent diffusion of specific proteins between mother and daughter cells

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001144.5 Reference assembly

    Range
    762575..764137 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001182203.2 → NP_013418.2  TPA: septin CDC3 [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_013418.2

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6VYV8, P32457, Q06161
    UniProtKB/TrEMBL
    A7A1J9, B3RHJ2, B5VNL3, G2WJD7
    Conserved Domains (1) summary
    COG5019
    Location:97 → 503
    CDC3; Septin family protein [Cell cycle control, cell division, chromosome partitioning, Cytoskeleton]
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P32457.3

Gene LinkOut

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