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bifunctional fructose-2,6-bisphosphate 2-phosphatase/6-phosphofructo-2-kinase [ Saccharomyces cerevisiae S288C ]

Gene ID: 851059, updated on 2-Nov-2024

Summary

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Official Full Name
bifunctional fructose-2,6-bisphosphate 2-phosphatase/6-phosphofructo-2-kinase
Primary source
SGD:S000004337
Locus tag
YLR345W
See related
AllianceGenome:SGD:S000004337; FungiDB:YLR345W; VEuPathDB:YLR345W
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary
Predicted to enable 6-phosphofructo-2-kinase activity and fructose-2,6-bisphosphate 2-phosphatase activity. Predicted to be involved in fructose 2,6-bisphosphate metabolic process. Located in cytoplasm. [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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Location:
chromosome: XII
Exon count:
1
Sequence:
Chromosome: XII; NC_001144.5 (820511..822040)

Chromosome XII - NC_001144.5Genomic Context describing neighboring genes Neighboring gene tRNA-Arg Neighboring gene ribosomal 60S subunit protein L26A Neighboring gene Cis1p Neighboring gene karyopherin beta

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001144.5

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Identification of new genes regulated by the Crt1 transcription factor, an effector of the DNA damage checkpoint pathway in Saccharomyces cerevisiae. Zaim J, et al. J Biol Chem, 2005 Jan 7. PMID 15494396
  2. Protein acetylation microarray reveals that NuA4 controls key metabolic target regulating gluconeogenesis. Lin YY, et al. Cell, 2009 Mar 20. PMID 19303850, Free PMC Article
  3. Genetic interaction network of the Saccharomyces cerevisiae type 1 phosphatase Glc7. Logan MR, et al. BMC Genomics, 2008 Jul 15. PMID 18627629, Free PMC Article
  4. Functional profiling of the Saccharomyces cerevisiae genome. Giaever G, et al. Nature, 2002 Jul 25. PMID 12140549
  5. A role for the budding yeast separase, Esp1, in Ty1 element retrotransposition. Ho KL, et al. PLoS Genet, 2015 Mar. PMID 25822502, Free PMC Article

See all (30) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables 6-phosphofructo-2-kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables 6-phosphofructo-2-kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables 6-phosphofructo-2-kinase activity NAS
Non-traceable Author Statement
more info
 PubMed 
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables fructose-2,6-bisphosphate 2-phosphatase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables fructose-2,6-bisphosphate 2-phosphatase activity IEA
Inferred from Electronic Annotation
more info
  
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
  
enables kinase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in carbohydrate phosphorylation IEA
Inferred from Electronic Annotation
more info
  
involved_in fructose 2,6-bisphosphate metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in fructose 2,6-bisphosphate metabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in fructose 2,6-bisphosphate metabolic process NAS
Non-traceable Author Statement
more info
 PubMed 
involved_in fructose metabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in phosphorylation IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of glycolytic process NAS
Non-traceable Author Statement
more info
 PubMed 
Component Evidence Code Pubs
located_in cytoplasm HDA PubMed 
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
bifunctional fructose-2,6-bisphosphate 2-phosphatase/6-phosphofructo-2-kinase
NP_013449.1
  • Similar to 6-phosphofructo-2-kinase enzymes; mRNA expression is repressed by the Rfx1p-Tup1p-Ssn6p repressor complex; YLR345W is not an essential gene

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001144.5 Reference assembly

    Range
    820511..822040
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001182234.1 → NP_013449.1  TPA: bifunctional fructose-2,6-bisphosphate 2-phosphatase/6-phosphofructo-2-kinase [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_013449.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6VYY4, Q06137
    UniProtKB/TrEMBL
    B3RHL5, B5VNN7, C8ZDV2, N1NYN3
    Conserved Domains (2) summary
    COG0406
    Location:290 → 505
    PhoE; Broad specificity phosphatase PhoE [Carbohydrate transport and metabolism]
    pfam01591
    Location:71 → 291
    6PF2K; 6-phosphofructo-2-kinase
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q06137.1

Gene LinkOut

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