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VPS38 Vps38p [ Saccharomyces cerevisiae S288C ]

Gene ID: 851074, updated on 18-Sep-2024

Summary

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Official Symbol
VPS38
Official Full Name
Vps38p
Primary source
SGD:S000004352
Locus tag
YLR360W
See related
AllianceGenome:SGD:S000004352; FungiDB:YLR360W; VEuPathDB:YLR360W
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Also known as
VPL17
Summary
Predicted to enable SNARE binding activity. Involved in late endosome to vacuole transport and macroautophagy. Located in fungal-type vacuole membrane. Part of phosphatidylinositol 3-kinase complex, class III, type II. [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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See VPS38 in Genome Data Viewer
Location:
chromosome: XII
Exon count:
1
Sequence:
Chromosome: XII; NC_001144.5 (846103..847422)

Chromosome XII - NC_001144.5Genomic Context describing neighboring genes Neighboring gene Rsc2p Neighboring gene uncharacterized protein Neighboring gene adenylosuccinase ADE13 Neighboring gene phosphoprotein phosphatase Neighboring gene uncharacterized protein Neighboring gene mitogen-activated protein kinase kinase kinase STE11

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001144.5

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. The PI3 Kinase Complex II-PI3P-Vps27 Axis on Vacuolar Membranes is Critical for Microautophagy Induction and Nutrient Stress Adaptation. Tasnin MN, et al. J Mol Biol, 2022 Jan 30. PMID 34798133
  2. Structure of the novel C-terminal domain of vacuolar protein sorting 30/autophagy-related protein 6 and its specific role in autophagy. Noda NN, et al. J Biol Chem, 2012 May 11. PMID 22437838, Free PMC Article
  3. Structure and flexibility of the endosomal Vps34 complex reveals the basis of its function on membranes. Rostislavleva K, et al. Science, 2015 Oct 9. PMID 26450213, Free PMC Article
  4. Chemical genomic guided engineering of gamma-valerolactone tolerant yeast. Bottoms S, et al. Microb Cell Fact, 2018 Jan 12. PMID 29329531, Free PMC Article
  5. Autophagosome formation can be achieved in the absence of Atg18 by expressing engineered PAS-targeted Atg2. Kobayashi T, et al. FEBS Lett, 2012 Jul 30. PMID 22728243

See all (77) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables SNARE binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables molecular_function ND
No biological Data available
more info
  
Process Evidence Code Pubs
involved_in SNARE complex assembly IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in cellular response to potassium ion starvation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in late endosome to vacuole transport IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in macroautophagy IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in protein transport IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in Golgi apparatus IEA
Inferred from Electronic Annotation
more info
  
is_active_in endosome IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in endosome IEA
Inferred from Electronic Annotation
more info
  
located_in endosome membrane IEA
Inferred from Electronic Annotation
more info
  
located_in fungal-type vacuole membrane HDA PubMed 
is_active_in lytic vacuole IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
part_of phosphatidylinositol 3-kinase complex, class III, type II IDA
Inferred from Direct Assay
more info
 PubMed 
part_of phosphatidylinositol 3-kinase complex, class III, type II IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
Vps38p
NP_013464.3
  • Part of a Vps34p phosphatidylinositol 3-kinase complex; functions in carboxypeptidase Y (CPY) sorting; binds Vps30p and Vps34p to promote production of phosphatidylinositol 3-phosphate (PtdIns3P) which stimulates kinase activity; required for overflow degradation of misfolded proteins when ERAD is saturated; targeted to vacuole via AP-3 pathway

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001144.5 Reference assembly

    Range
    846103..847422
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001182249.3 → NP_013464.3  TPA: Vps38p [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_013464.3

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6VYZ7, Q05919, Q6B1J7
    UniProtKB/TrEMBL
    B3RHM8, B5VNQ1, C7GRY4, C8ZDW7
    Conserved Domains (1) summary
    pfam17649
    Location:1 → 436
    VPS38; Vacuolar protein sorting 38
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q05919.1

Gene LinkOut

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