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NMD4 Nmd4p [ Saccharomyces cerevisiae S288C ]

Gene ID: 851077, updated on 18-Sep-2024

Summary

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Official Symbol
NMD4
Official Full Name
Nmd4p
Primary source
SGD:S000004355
Locus tag
YLR363C
See related
AllianceGenome:SGD:S000004355; FungiDB:YLR363C; VEuPathDB:YLR363C
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary
Involved in nuclear-transcribed mRNA catabolic process, nonsense-mediated decay. Located in cytoplasm and nucleus. [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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See NMD4 in Genome Data Viewer
Location:
chromosome: XII
Exon count:
1
Sequence:
Chromosome: XII; NC_001144.5 (852495..853151, complement)

Chromosome XII - NC_001144.5Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene mitogen-activated protein kinase kinase kinase STE11 Neighboring gene uncharacterized protein Neighboring gene glutathione-disulfide reductase GRX8

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001144.5

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Identification of a novel component of the nonsense-mediated mRNA decay pathway by use of an interacting protein screen. He F, et al. Genes Dev, 1995 Feb 15. PMID 7883168
  2. Nonsense-mediated decay regulates key components of homologous recombination. Janke R, et al. Nucleic Acids Res, 2016 Jun 20. PMID 27001511, Free PMC Article
  3. Interactions of subunit CCT3 in the yeast chaperonin CCT/TRiC with Q/N-rich proteins revealed by high-throughput microscopy analysis. Nadler-Holly M, et al. Proc Natl Acad Sci U S A, 2012 Nov 13. PMID 23112166, Free PMC Article
  4. An evolutionary proteomics approach identifies substrates of the cAMP-dependent protein kinase. Budovskaya YV, et al. Proc Natl Acad Sci U S A, 2005 Sep 27. PMID 16172400, Free PMC Article
  5. Nonsense-mediated mRNA decay involves two distinct Upf1-bound complexes. Dehecq M, et al. EMBO J, 2018 Nov 2. PMID 30275269, Free PMC Article

See all (23) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables molecular_function ND
No biological Data available
more info
  
Process Evidence Code Pubs
involved_in nuclear-transcribed mRNA catabolic process, nonsense-mediated decay IEA
Inferred from Electronic Annotation
more info
  
involved_in nuclear-transcribed mRNA catabolic process, nonsense-mediated decay IPI
Inferred from Physical Interaction
more info
 PubMed 
Component Evidence Code Pubs
located_in cytoplasm HDA PubMed 
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in nucleus HDA PubMed 

General protein information

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Preferred Names
Nmd4p
NP_013467.3
  • Protein that may be involved in nonsense-mediated mRNA decay; interacts with Nam7p, relocalizes from nucleus to cytoplasmic foci upon DNA replication stress

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001144.5 Reference assembly

    Range
    852495..853151 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001182252.3 → NP_013467.3  TPA: Nmd4p [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_013467.3

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6VZ01, Q12129
    UniProtKB/TrEMBL
    A7A1P1, B3RHN1, B5VNQ4, C7GRV8, C8ZDX1, G2WJI1, N1NZP9
    Conserved Domains (1) summary
    cd18717
    Location:7 → 155
    PIN_ScNmd4p-like; VapC-like PIN domain of Saccharomyces cerevisiae Nmd4p and related proteins
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q12129.1

Gene LinkOut

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