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PSY3 Psy3p [ Saccharomyces cerevisiae S288C ]

Gene ID: 851091, updated on 18-Sep-2024

Summary

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Official Symbol
PSY3
Official Full Name
Psy3p
Primary source
SGD:S000004368
Locus tag
YLR376C
See related
AllianceGenome:SGD:S000004368; FungiDB:YLR376C; VEuPathDB:YLR376C
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary
Involved in DNA recombinase assembly and error-free translesion synthesis. Located in nucleus and site of double-strand break. Part of Shu complex. [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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See PSY3 in Genome Data Viewer
Location:
chromosome: XII
Exon count:
1
Sequence:
Chromosome: XII; NC_001144.5 (872826..873554, complement)

Chromosome XII - NC_001144.5Genomic Context describing neighboring genes Neighboring gene Vid22p Neighboring gene Stp3p Neighboring gene fructose 1,6-bisphosphate 1-phosphatase Neighboring gene tRNA-Lys

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001144.5

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. The yeast FBP1 poly(A) signal functions in both orientations and overlaps with a gene promoter. Aranda A, et al. Nucleic Acids Res, 1998 Oct 15. PMID 9753725, Free PMC Article
  2. Genome-wide identification of genes conferring resistance to the anticancer agents cisplatin, oxaliplatin, and mitomycin C. Wu HI, et al. Cancer Res, 2004 Jun 1. PMID 15173006
  3. The YJL185C, YLR376C and YJR129C genes of Saccharomyces cerevisiae are probably involved in regulation of the glyoxylate cycle. Boniewska-Bernacka E, et al. Acta Biochim Pol, 2006. PMID 17146497
  4. Structural analysis of Shu proteins reveals a DNA binding role essential for resisting damage. Tao Y, et al. J Biol Chem, 2012 Jun 8. PMID 22465956, Free PMC Article
  5. Structural and SAXS analysis of the budding yeast SHU-complex proteins. She Z, et al. FEBS Lett, 2012 Jul 30. PMID 22749910

See all (55) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Study provides evidence that DNA-binding components of the budding yeast Shu complex, Csm2-Psy3, bind double-flap DNA substrates containing an abasic site analog, and increase chromatin association when abasic sites accumulate. Importantly, Csm2-Psy3 blocks AP endonuclease cleavage at a double-flap DNA substrate, thus preventing in vitro double-strand break formation.
    Title: The Rad51 paralogs facilitate a novel DNA strand specific damage tolerance pathway.
  2. Data indicate that Csm2, Psy3, Shu1 and Shu2 interact with each other in sequence to form a V-shape overall structure in Shu complex.
    Title: Structural basis for the functional role of the Shu complex in homologous recombination.
  3. The data suggest a model in which Csm2-Psy3 recruit the Shu complex to homologous recombination substrates, where it interacts with Rad51 through Rad55-Rad57 to stimulate Rad51 filament assembly and stability, promoting error-free repair.
    Title: The Shu complex interacts with Rad51 through the Rad51 paralogues Rad55-Rad57 to mediate error-free recombination.
  4. analysis of the crystal structure of the Psy3-Csm2 sub-complex
    Title: Structural and SAXS analysis of the budding yeast SHU-complex proteins.
  5. the contribution of the ER24 gene product Ylr376Cp and of the two suppressor gene products Yjl185Cp and Yjr129Cp to a complex regulation of the glyoxylate cycle in yeast.
    Title: The YJL185C, YLR376C and YJR129C genes of Saccharomyces cerevisiae are probably involved in regulation of the glyoxylate cycle.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables molecular_function ND
No biological Data available
more info
  
Process Evidence Code Pubs
involved_in DNA recombinase assembly IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in DNA repair IEA
Inferred from Electronic Annotation
more info
  
involved_in error-free translesion synthesis IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in recombinational repair IEA
Inferred from Electronic Annotation
more info
  
involved_in recombinational repair IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in recombinational repair IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
part_of Shu complex IDA
Inferred from Direct Assay
more info
 PubMed 
part_of Shu complex IEA
Inferred from Electronic Annotation
more info
  
part_of Shu complex IPI
Inferred from Physical Interaction
more info
 PubMed 
located_in cytoplasm HDA PubMed 
located_in cytosol HDA PubMed 
located_in nucleus HDA PubMed 
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  
located_in site of double-strand break IMP
Inferred from Mutant Phenotype
more info
 PubMed 

General protein information

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Preferred Names
Psy3p
NP_013480.1
  • Component of Shu complex (aka PCSS complex); Shu complex also includes Shu1, Csm2, Shu2, and promotes error-free DNA repair; promotes Rad51p filament assembly; Shu complex mediates inhibition of Srs2p function; Psy3p and Csm2p contain similar DNA-binding regions which work together to form a single DNA binding site; deletion of PSY3 results in a mutator phenotype; deletion increases sensitivity to anticancer drugs oxaliplatin and cisplatin but not mitomycin C

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001144.5 Reference assembly

    Range
    872826..873554 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001182265.1 → NP_013480.1  TPA: Psy3p [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_013480.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6VZ12, Q12318
    UniProtKB/TrEMBL
    A7A1Q2, B3RHP2, C7GRW8, C8ZDY6, G2WJJ2, N1P7A0
    Conserved Domains (1) summary
    cd19480
    Location:2 → 226
    Psy3; Shu complex subunit Psy3
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q12318.1

Gene LinkOut

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