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CST9 SUMO ligase CST9 [ Saccharomyces cerevisiae S288C ]

Gene ID: 851110, updated on 28-Oct-2024

Summary

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Official Symbol
CST9
Official Full Name
SUMO ligase CST9
Primary source
SGD:S000004386
Locus tag
YLR394W
See related
AllianceGenome:SGD:S000004386; FungiDB:YLR394W; VEuPathDB:YLR394W
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Also known as
ZIP3
Summary
Enables SUMO transferase activity and chromatin binding activity. Involved in double-strand break repair via homologous recombination; meiosis I; and protein sumoylation. Located in condensed nuclear chromosome. Is active in chromosome, centromeric region and site of double-strand break. [provided by Alliance of Genome Resources, Oct 2024]
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Genomic context

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See CST9 in Genome Data Viewer
Location:
chromosome: XII
Exon count:
1
Sequence:
Chromosome: XII; NC_001144.5 (907950..909398)

Chromosome XII - NC_001144.5Genomic Context describing neighboring genes Neighboring gene Art10p Neighboring gene Atp10p Neighboring gene cytochrome c oxidase subunit VIII Neighboring gene tethering complex ATP-binding subunit VPS33

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001144.5

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Tying synaptonemal complex initiation to the formation and programmed repair of DNA double-strand breaks. Henderson KA, et al. Proc Natl Acad Sci U S A, 2004 Mar 30. PMID 15070750, Free PMC Article
  2. Imposition of crossover interference through the nonrandom distribution of synapsis initiation complexes. Fung JC, et al. Cell, 2004 Mar 19. PMID 15035982
  3. Meiotic prophase roles of Rec8 in crossover recombination and chromosome structure. Yoon SW, et al. Nucleic Acids Res, 2016 Nov 2. PMID 27484478, Free PMC Article
  4. Control of meiotic pairing and recombination by chromosomally tethered 26S proteasome. Ahuja JS, et al. Science, 2017 Jan 27. PMID 28059715, Free PMC Article
  5. The Arabidopsis HEI10 is a new ZMM protein related to Zip3. Chelysheva L, et al. PLoS Genet, 2012. PMID 22844245, Free PMC Article

See all (67) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. A tel1Delta mutant has globally increased amounts of Spo11-oligonucleotide complexes and altered Spo11-oligonucleotide lengths, consistent with conserved roles for Tel1 in control of DSB number and processing..We further find that effects of Tel1 are distinct but partially overlapping with previously described contributions of the recombination regulator Cst9 (also known as Zip3).
    Title: Numerical and spatial patterning of yeast meiotic DNA breaks by Tel1.
  2. proteolytic core and regulatory proteasome particles were recruited to chromosomes by Zip3, the ortholog of mammalian E3 ligase RNF212, and synaptonemal complex protein Zip1 .
    Title: Control of meiotic pairing and recombination by chromosomally tethered 26S proteasome.
  3. We show that Zip3 associates with DSB sites that are engaged in repair by CO, and Zip3 enrichment at DSBs reflects the DSB tendency to be repaired by CO.
    Title: Differential association of the conserved SUMO ligase Zip3 with meiotic double-strand break sites reveals regional variations in the outcome of meiotic recombination.
  4. Spo22 (also called Zip4) is identified as a probable functional collaborator of Zip2/3
    Title: Bioinformatic analyses implicate the collaborating meiotic crossover/chiasma proteins Zip2, Zip3, and Spo22/Zip4 in ubiquitin labeling.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables SUMO transferase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables SUMO transferase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables SUMO transferase activity IEA
Inferred from Electronic Annotation
more info
  
enables SUMO transferase activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables chromatin binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables chromatin binding IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables zinc ion binding RCA
inferred from Reviewed Computational Analysis
more info
 PubMed 
Process Evidence Code Pubs
involved_in DNA repair IEA
Inferred from Electronic Annotation
more info
  
involved_in double-strand break repair via homologous recombination IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in double-strand break repair via homologous recombination IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in homologous chromosome pairing at meiosis IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in homologous chromosome pairing at meiosis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in meiotic cell cycle IEA
Inferred from Electronic Annotation
more info
  
involved_in protein sumoylation IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in protein sumoylation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in reciprocal meiotic recombination IEA
Inferred from Electronic Annotation
more info
  
involved_in reciprocal meiotic recombination IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in synaptonemal complex assembly IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in chromosome IEA
Inferred from Electronic Annotation
more info
  
is_active_in chromosome, centromeric region IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in chromosome, centromeric region IMP
Inferred from Mutant Phenotype
more info
 PubMed 
located_in condensed nuclear chromosome IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nuclear chromosome IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  
is_active_in site of double-strand break IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in site of double-strand break IMP
Inferred from Mutant Phenotype
more info
 PubMed 
is_active_in synaptonemal complex IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in synaptonemal complex IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
SUMO ligase CST9
NP_013498.3
  • SUMO E3 ligase; required for synaptonemal complex formation; localizes to synapsis initiation sites on meiotic chromosomes; associates with centromeres early in meiosis, then with chromosome axes and finally with double-strand break sites that are engaged in repair by crossovers; potential Cdc28p substrate

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001144.5 Reference assembly

    Range
    907950..909398
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001182282.3 → NP_013498.3  TPA: SUMO ligase CST9 [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_013498.3

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6VZ29, Q06032
    UniProtKB/TrEMBL
    A7A1R9, G2WJK9, N1P7B8
    Conserved Domains (1) summary
    pfam14634
    Location:54 → 92
    zf-RING_5; zinc-RING finger domain
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q06032.1

Gene LinkOut

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