DUS3 tRNA dihydrouridine synthase DUS3 [Saccharomyces cerevisiae S288C] - Gene

Summary

Gene symbol: DUS3
Gene description: tRNA dihydrouridine synthase DUS3
Primary source: FungiDB:YLR401C
Locus tag: YLR401C
See related: SGD:S000004393; AllianceGenome:SGD:S000004393; VEuPathDB:YLR401C
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Saccharomyces cerevisiae S288C (strain: S288C)
Lineage: Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary: Enables tRNA dihydrouridine synthase activity. Involved in tRNA modification. Located in nuclear periphery. Orthologous to human DUS3L (dihydrouridine synthase 3 like). [provided by Alliance of Genome Resources, Apr 2022]
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Chromosome XII - NC_001144.5 Genomic Context describing neighboring genes

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

Function	Evidence Code	Pubs
enables flavin adenine dinucleotide binding	IEA Inferred from Electronic Annotation more info
enables mRNA binding	HDA more info	PubMed
enables mRNA dihydrouridine synthase activity	IEA Inferred from Electronic Annotation more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables oxidoreductase activity	IEA Inferred from Electronic Annotation more info
enables tRNA dihydrouridine synthase activity	IBA Inferred from Biological aspect of Ancestor more info
enables tRNA dihydrouridine synthase activity	IEA Inferred from Electronic Annotation more info
enables tRNA dihydrouridine synthase activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables tRNA-dihydrouridine47 synthase activity	IEA Inferred from Electronic Annotation more info
enables zinc ion binding	RCA inferred from Reviewed Computational Analysis more info	PubMed

Process	Evidence Code	Pubs
involved_in mRNA processing	IEA Inferred from Electronic Annotation more info
involved_in tRNA dihydrouridine synthesis	IEA Inferred from Electronic Annotation more info
involved_in tRNA modification	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in tRNA processing	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in cytoplasm	HDA more info	PubMed
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in nuclear periphery	IDA Inferred from Direct Assay more info	PubMed
located_in nucleus	HDA more info	PubMed
located_in nucleus	IEA Inferred from Electronic Annotation more info

NP_013505.4

Dihydrouridine synthase; member of a widespread family of conserved proteins including Smm1p, Dus1p, and Dus4p; modifies pre-tRNAs at U47 of the variable arm; contains a consensus oleate response element (ORE) in its promoter region; forms nuclear foci upon DNA replication stress

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The following sections contain reference sequences that belong to a specific genome build. Explain