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CTR3 high-affinity Cu transporter CTR3 [ Saccharomyces cerevisiae S288C ]

Gene ID: 851129, updated on 28-Oct-2024

Summary

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Official Symbol
CTR3
Official Full Name
high-affinity Cu transporter CTR3
Primary source
SGD:S000004403
Locus tag
YLR411W
See related
AllianceGenome:SGD:S000004403; FungiDB:YLR411W; VEuPathDB:YLR411W
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary
Enables copper ion transmembrane transporter activity. Involved in copper ion import. Located in plasma membrane. Orthologous to human SLC31A1 (solute carrier family 31 member 1) and SLC31A2 (solute carrier family 31 member 2). [provided by Alliance of Genome Resources, Oct 2024]
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Genomic context

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See CTR3 in Genome Data Viewer
Location:
chromosome: XII
Exon count:
1
Sequence:
Chromosome: XII; NC_001144.5 (947253..947978)

Chromosome XII - NC_001144.5Genomic Context describing neighboring genes Neighboring gene inositol polyphosphate kinase VIP1 Neighboring gene gag protein Neighboring gene gag-pol fusion protein Neighboring gene Ber1p Neighboring gene uncharacterized protein

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001144.5

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. A widespread transposable element masks expression of a yeast copper transport gene. Knight SA, et al. Genes Dev, 1996 Aug 1. PMID 8756349
  2. Characterization of the Saccharomyces cerevisiae high affinity copper transporter Ctr3. Pena MM, et al. J Biol Chem, 2000 Oct 27. PMID 10924521
  3. Tryptophan scanning analysis of the membrane domain of CTR-copper transporters. De Feo CJ, et al. J Membr Biol, 2010 Apr. PMID 20224886, Free PMC Article
  4. The Candida albicans CTR1 gene encodes a functional copper transporter. Marvin ME, et al. Microbiology (Reading), 2003 Jun. PMID 12777486
  5. Eukaryotic CTR copper uptake transporters require two faces of the third transmembrane domain for helix packing, oligomerization, and function. Aller SG, et al. J Biol Chem, 2004 Dec 17. PMID 15385536, Free PMC Article

See all (29) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables copper ion transmembrane transporter activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables copper ion transmembrane transporter activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in copper ion import IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in copper ion transmembrane transport IEA
Inferred from Electronic Annotation
more info
  
involved_in copper ion transport IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in cytoplasmic vesicle IEA
Inferred from Electronic Annotation
more info
  
located_in cytoplasmic vesicle membrane IEA
Inferred from Electronic Annotation
more info
  
located_in endoplasmic reticulum HDA PubMed 
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
located_in plasma membrane IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
high-affinity Cu transporter CTR3
NP_013515.3
  • High-affinity copper transporter of the plasma membrane; acts as a trimer; gene is disrupted by a Ty2 transposon insertion in many laboratory strains of S. cerevisiae

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001144.5 Reference assembly

    Range
    947253..947978
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001182299.3 → NP_013515.3  TPA: high-affinity Cu transporter CTR3 [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_013515.3

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6VZ47, Q06686
    UniProtKB/TrEMBL
    A7A1T4, B3RHS2, B5VNU4, C8ZE20
    Conserved Domains (1) summary
    pfam04145
    Location:20 → 210
    Ctr; Ctr copper transporter family
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q06686.1

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