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CDC73 Cdc73p [ Saccharomyces cerevisiae S288C ]

Gene ID: 851136, updated on 28-Oct-2024

Summary

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Official Symbol
CDC73
Official Full Name
Cdc73p
Primary source
SGD:S000004410
Locus tag
YLR418C
See related
AllianceGenome:SGD:S000004410; FungiDB:YLR418C; VEuPathDB:YLR418C
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary
Enables RNA polymerase II C-terminal domain phosphoserine binding activity and chromatin binding activity. Involved in DNA-templated transcription elongation; mRNA 3'-end processing; and regulation of nucleobase-containing compound metabolic process. Located in euchromatin and nucleus. Part of Cdc73/Paf1 complex. Human ortholog(s) of this gene implicated in hyperparathyroidism and parathyroid carcinoma. Orthologous to human CDC73 (cell division cycle 73). [provided by Alliance of Genome Resources, Oct 2024]
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Genomic context

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See CDC73 in Genome Data Viewer
Location:
chromosome: XII
Exon count:
1
Sequence:
Chromosome: XII; NC_001144.5 (956914..958095, complement)

Chromosome XII - NC_001144.5Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene ESCRT-II subunit protein VPS36 Neighboring gene putative helicase Neighboring gene tRNA-Leu

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001144.5

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Crystallographic analysis of the conserved C-terminal domain of transcription factor Cdc73 from Saccharomyces cerevisiae reveals a GTPase-like fold. Chen H, et al. Acta Crystallogr D Biol Crystallogr, 2012 Aug. PMID 22868760
  2. Cdc73 is a major regulator of apoptosis-inducing factor 1 expression in Saccharomyces cerevisiae via H3K36 methylation. Saha N, et al. FEBS Lett, 2024 Mar. PMID 38467538
  3. The Paf1 complex is required for efficient transcription elongation by RNA polymerase I. Zhang Y, et al. Proc Natl Acad Sci U S A, 2009 Feb 17. PMID 19164765, Free PMC Article
  4. HRPT2, encoding parafibromin, is mutated in hyperparathyroidism-jaw tumor syndrome. Carpten JD, et al. Nat Genet, 2002 Dec. PMID 12434154
  5. Molecular evidence indicating that the yeast PAF complex is required for transcription elongation. Rondón AG, et al. EMBO Rep, 2004 Jan. PMID 14710186, Free PMC Article

See all (178) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Cdc73 is a major regulator of apoptosis-inducing factor 1 expression in Saccharomyces cerevisiae via H3K36 methylation.
    Title: Cdc73 is a major regulator of apoptosis-inducing factor 1 expression in Saccharomyces cerevisiae via H3K36 methylation.
  2. Spt6 directly interacts with Cdc73 and is required for Paf1 complex occupancy at active genes in Saccharomyces cerevisiae.
    Title: Spt6 directly interacts with Cdc73 and is required for Paf1 complex occupancy at active genes in Saccharomyces cerevisiae.
  3. Telomere maintenance and genome instability are regulated by cdc73.
    Title: Cdc73 suppresses genome instability by mediating telomere homeostasis.
  4. Crystallographic analysis of the conserved C-terminal domain of transcription factor Cdc73 from Saccharomyces cerevisiae reveals a GTPase-like fold
    Title: Crystallographic analysis of the conserved C-terminal domain of transcription factor Cdc73 from Saccharomyces cerevisiae reveals a GTPase-like fold.
Submit: New GeneRIF Correction

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables RNA polymerase II C-terminal domain phosphoserine binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables RNA polymerase II complex binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables RNA polymerase II complex binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables chromatin binding IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
involved_in mRNA 3'-end processing IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in negative regulation of DNA recombination IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of transcription elongation by RNA polymerase I IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in positive regulation of transcription elongation by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in positive regulation of transcription elongation by RNA polymerase II IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of transcription-coupled nucleotide-excision repair IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in transcription elongation by RNA polymerase I IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in transcription elongation by RNA polymerase II IEA
Inferred from Electronic Annotation
more info
  
involved_in transcription elongation by RNA polymerase II IGI
Inferred from Genetic Interaction
more info
 PubMed 
Component Evidence Code Pubs
part_of Cdc73/Paf1 complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of Cdc73/Paf1 complex IEA
Inferred from Electronic Annotation
more info
  
part_of Cdc73/Paf1 complex IPI
Inferred from Physical Interaction
more info
 PubMed 
located_in euchromatin IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
Cdc73p
NP_013522.1
  • Component of the Paf1p complex; binds to and modulates the activity of RNA polymerases I and II; required for expression of certain genes, modification of some histones, and telomere maintenance; involved in transcription elongation as demonstrated by the G-less-based run-on (GLRO) assay; role in preventing L-A mycovirus pathogenesis; protein abundance increases in response to DNA replication stress; human homolog, parafibromin, is a tumour suppressor linked to breast, renal and gastric cancers

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001144.5 Reference assembly

    Range
    956914..958095 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001182306.1 → NP_013522.1  TPA: Cdc73p [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_013522.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6VZ54, Q06697
    UniProtKB/TrEMBL
    B3RHS8, B5VNV0, C7GXL9, G2WJN0, N1NZW0
    Conserved Domains (1) summary
    COG5157
    Location:1 → 393
    CDC73; RNA polymerase II assessory factor [Transcription]
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q06697.1

Gene LinkOut

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