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URA4 dihydroorotase [ Saccharomyces cerevisiae S288C ]

Gene ID: 851139, updated on 28-Oct-2024

Summary

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Official Symbol
URA4
Official Full Name
dihydroorotase
Primary source
SGD:S000004412
Locus tag
YLR420W
See related
AllianceGenome:SGD:S000004412; FungiDB:YLR420W; VEuPathDB:YLR420W
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary
Enables dihydroorotase activity. Involved in 'de novo' pyrimidine nucleobase biosynthetic process and pyrimidine nucleotide biosynthetic process. Located in cytoplasm and nucleus. [provided by Alliance of Genome Resources, Oct 2024]
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Genomic context

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See URA4 in Genome Data Viewer
Location:
chromosome: XII
Exon count:
1
Sequence:
Chromosome: XII; NC_001144.5 (963785..964879)

Chromosome XII - NC_001144.5Genomic Context describing neighboring genes Neighboring gene putative helicase Neighboring gene tRNA-Leu Neighboring gene proteasome regulatory particle lid subunit RPN13 Neighboring gene Dck1p

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001144.5

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Structure of the Saccharomyces cerevisiae URA4 gene encoding dihydroorotase. Guyonvarch A, et al. Mol Gen Genet, 1988 Apr. PMID 2897615
  2. Cloning of the PYR3 gene of Ustilago maydis and its use in DNA transformation. Banks GR, et al. Mol Cell Biol, 1988 Dec. PMID 2907604, Free PMC Article
  3. Complexed Crystal Structure of Saccharomyces cerevisiae Dihydroorotase with Inhibitor 5-Fluoroorotate Reveals a New Binding Mode. Guan HH, et al. Bioinorg Chem Appl, 2021. PMID 34630544, Free PMC Article
  4. Creation of a putative third metal binding site in type II dihydroorotases significantly enhances enzyme activity. Huang YH, et al. Protein Pept Lett, 2015. PMID 26446564
  5. Centromere silencing and function in fission yeast is governed by the amino terminus of histone H3. Mellone BG, et al. Curr Biol, 2003 Oct 14. PMID 14561399

See all (38) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables dihydroorotase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables dihydroorotase activity IEA
Inferred from Electronic Annotation
more info
  
enables dihydroorotase activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables zinc ion binding RCA
inferred from Reviewed Computational Analysis
more info
 PubMed 
Process Evidence Code Pubs
involved_in 'de novo' UMP biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
involved_in 'de novo' pyrimidine nucleobase biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in 'de novo' pyrimidine nucleobase biosynthetic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in pyrimidine nucleobase biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
involved_in pyrimidine nucleotide biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in pyrimidine nucleotide biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
involved_in pyrimidine nucleotide biosynthetic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in cytoplasm HDA PubMed 
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus HDA PubMed 

General protein information

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Preferred Names
dihydroorotase
NP_013524.1
  • Dihydroorotase; catalyzes the third enzymatic step in the de novo biosynthesis of pyrimidines, converting carbamoyl-L-aspartate into dihydroorotate

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001144.5 Reference assembly

    Range
    963785..964879
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001182308.1 → NP_013524.1  TPA: dihydroorotase [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_013524.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6VZ56, P20051
    UniProtKB/TrEMBL
    A7A1U1, G2WJN2
    Conserved Domains (1) summary
    TIGR00856
    Location:4 → 360
    pyrC_dimer; dihydroorotase, homodimeric type
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P20051.2

Gene LinkOut

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