ATG17 protein kinase regulatory subunit ATG17 [Saccharomyces cerevisiae S288C] - Gene

Summary

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Official Symbol: ATG17
Official Full Name: protein kinase regulatory subunit ATG17
Primary source: SGD:S000004415
Locus tag: YLR423C
See related: AllianceGenome:SGD:S000004415; FungiDB:YLR423C; VEuPathDB:YLR423C
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Saccharomyces cerevisiae S288C (strain: S288C)
Lineage: Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Also known as: APG17
Summary: Enables SNARE binding activity; molecular adaptor activity; and protein kinase activator activity. Involved in several processes, including cellular response to nitrogen starvation; macroautophagy; and positive regulation of autophagosome assembly. Located in phagophore assembly site and vacuole-isolation membrane contact site. Part of Atg1/ULK1 kinase complex. [provided by Alliance of Genome Resources, Oct 2024]
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Genomic context

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See ATG17 in Genome Data Viewer

Location:: chromosome: XII

Exon count:: 1

Sequence:: Chromosome: XII; NC_001144.5 (971917..973170, complement)

Chromosome XII - NC_001144.5 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_001144.5

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

TOR-mediated Ypt1 phosphorylation regulates autophagy initiation complex assembly.
Title: TOR-mediated Ypt1 phosphorylation regulates autophagy initiation complex assembly.
Atg17 adopts multiple conformations in the absence of Atg31 and Atg29 suggests that the two smaller components play key roles in defining and maintaining the distinct curvature of the ternary complex
Title: Structural characterization of the Saccharomyces cerevisiae autophagy regulatory complex Atg17-Atg31-Atg29.
single-particle electron microscopy analysis of the Atg17-Atg31-Atg29 complex reveals an elongated structure with Atg29 located at the opposing ends.
Title: Atg29 phosphorylation regulates coordination of the Atg17-Atg31-Atg29 complex with the Atg11 scaffold during autophagy initiation.
The PAS scaffold proteins (Atg13 and Atg17) and phosphatidylinositol 3-kinase complex I were localized to a position at the junction between the IM and the vacuolar membrane, termed the vacuole-IM contact site (VICS).
Title: Fine mapping of autophagy-related proteins during autophagosome formation in Saccharomyces cerevisiae.
in autophagy-inducing condition, Atg9 is recruited to the pre-autophagosomal structure in a manner dependent on Atg17
Title: Atg17 recruits Atg9 to organize the pre-autophagosomal structure.
Atg17-Atg29-Atg31 ternary complex acts as a functional unit for autophagosome formation.
Title: Characterization of the Atg17-Atg29-Atg31 complex specifically required for starvation-induced autophagy in Saccharomyces cerevisiae.
Atg17 regulates the magnitude of the autophagic response
Title: Atg17 regulates the magnitude of the autophagic response.
Atg17-Atg13 complex formation plays an important role in normal autophagosome formation via binding to and activating the Atg1 kinase.
Title: Atg17 functions in cooperation with Atg1 and Atg13 in yeast autophagy.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

Orthologs from OrthoDB

Gene Ontology Provided by SGD

Function	Evidence Code	Pubs
enables SNARE binding	IDA Inferred from Direct Assay more info	PubMed
enables molecular adaptor activity	IBA Inferred from Biological aspect of Ancestor more info
enables molecular adaptor activity	IGI Inferred from Genetic Interaction more info	PubMed
enables protein kinase activator activity	IBA Inferred from Biological aspect of Ancestor more info
enables protein kinase activator activity	IMP Inferred from Mutant Phenotype more info	PubMed

Process	Evidence Code	Pubs
involved_in autophagosome assembly	IBA Inferred from Biological aspect of Ancestor more info
involved_in autophagosome assembly	IDA Inferred from Direct Assay more info	PubMed
involved_in autophagosome assembly	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in autophagy	IEA Inferred from Electronic Annotation more info
involved_in autophagy of mitochondrion	IBA Inferred from Biological aspect of Ancestor more info
involved_in autophagy of mitochondrion	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in autophagy of peroxisome	IBA Inferred from Biological aspect of Ancestor more info
involved_in cellular response to nitrogen starvation	IDA Inferred from Direct Assay more info	PubMed
involved_in nucleophagy	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in pexophagy	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in piecemeal microautophagy of the nucleus	IBA Inferred from Biological aspect of Ancestor more info
involved_in piecemeal microautophagy of the nucleus	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of autophagosome assembly	IGI Inferred from Genetic Interaction more info	PubMed
involved_in positive regulation of autophagosome size	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in protein localization to phagophore assembly site	IDA Inferred from Direct Assay more info	PubMed

Component	Evidence Code	Pubs
part_of Atg1/ULK1 kinase complex	IBA Inferred from Biological aspect of Ancestor more info
part_of Atg1/ULK1 kinase complex	IDA Inferred from Direct Assay more info	PubMed
part_of Atg1/ULK1 kinase complex	IPI Inferred from Physical Interaction more info	PubMed
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in membrane	IEA Inferred from Electronic Annotation more info
located_in nucleus	HDA more info	PubMed
is_active_in phagophore assembly site	IBA Inferred from Biological aspect of Ancestor more info
located_in phagophore assembly site	IDA Inferred from Direct Assay more info	PubMed
located_in phagophore assembly site membrane	IEA Inferred from Electronic Annotation more info
located_in vacuole-isolation membrane contact site	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: protein kinase regulatory subunit ATG17

NP_013527.3

Scaffold protein responsible for phagophore assembly site organization; regulatory subunit of an autophagy-specific complex that includes Atg1p and Atg13p; stimulates Atg1p kinase activity; human ortholog RB1CC1/FIP200 interacts with p53, which inhibits autophagy in human cells

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_001144.5 Reference assembly

Range

971917..973170 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001182311.3 → NP_013527.3 TPA: protein kinase regulatory subunit ATG17 [Saccharomyces cerevisiae S288C]

See identical proteins and their annotated locations for NP_013527.3

Status: REVIEWED

UniProtKB/Swiss-Prot

D6VZ59, Q06410

UniProtKB/TrEMBL

B3RHT3, B5VNV8, C7GXM4, C8ZE31, N1NZW4

Conserved Domains (1) summary

pfam04108
Location:8 → 404

APG17; Autophagy protein Apg17