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TUS1 Rho family guanine nucleotide exchange factor TUS1 [ Saccharomyces cerevisiae S288C ]

Gene ID: 851145, updated on 2-Nov-2024

Summary

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Official Symbol
TUS1
Official Full Name
Rho family guanine nucleotide exchange factor TUS1
Primary source
SGD:S000004417
Locus tag
YLR425W
See related
AllianceGenome:SGD:S000004417; FungiDB:YLR425W; VEuPathDB:YLR425W
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Also known as
SOP10
Summary
Enables guanyl-nucleotide exchange factor activity. Involved in fungal-type cell wall organization; positive regulation of mitotic actomyosin contractile ring assembly; and signal transduction. Located in cellular bud neck and incipient cellular bud site. [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See TUS1 in Genome Data Viewer
Location:
chromosome: XII
Exon count:
1
Sequence:
Chromosome: XII; NC_001144.5 (982894..986817)

Chromosome XII - NC_001144.5Genomic Context describing neighboring genes Neighboring gene mRNA splicing protein SPP382 Neighboring gene tRNA-Asn Neighboring gene Tda5p Neighboring gene Mag2p

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001144.5

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. A comparative analysis of NADPH supply strategies in Saccharomyces cerevisiae: Production of d-xylitol from d-xylose as a case study. Regmi P, et al. Metab Eng Commun, 2024 Dec. PMID 39072283, Free PMC Article
  2. Yeast Cell Wall Chitin Reduces Wine Haze Formation. Ndlovu T, et al. Appl Environ Microbiol, 2018 Jul 1. PMID 29703738, Free PMC Article
  3. Polo-like kinase Cdc5 controls the local activation of Rho1 to promote cytokinesis. Yoshida S, et al. Science, 2006 Jul 7. PMID 16763112
  4. Sro7 and Sro77, the yeast homologues of the Drosophila lethal giant larvae (Lgl), regulate cell proliferation via the Rho1-Tor1 pathway. Liou LC, et al. Microbiology (Reading), 2014 Oct. PMID 25061043, Free PMC Article
  5. G1/S cyclin-dependent kinase regulates small GTPase Rho1p through phosphorylation of RhoGEF Tus1p in Saccharomyces cerevisiae. Kono K, et al. Mol Biol Cell, 2008 Apr. PMID 18256282, Free PMC Article

See all (65) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. propose that Cln2p/Cdc28p-dependent phosphorylation of Tus1p is required for appropriate temporal and spatial activation of Rho1p at the G1/S transition
    Title: G1/S cyclin-dependent kinase regulates small GTPase Rho1p through phosphorylation of RhoGEF Tus1p in Saccharomyces cerevisiae.
  2. Transport assays show that Tus1p, a guanine nucleotide exchange factor (GEF) for the small GTPase Rho1p, is a Rho1p-dependent-positive regulator of Ycf1p.
    Title: Mapping protein-protein interactions for the yeast ABC transporter Ycf1p by integrated split-ubiquitin membrane yeast two-hybrid analysis.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables guanyl-nucleotide exchange factor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables guanyl-nucleotide exchange factor activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables guanyl-nucleotide exchange factor activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in fungal-type cell wall organization IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of mitotic actomyosin contractile ring assembly IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in positive regulation of mitotic actomyosin contractile ring assembly IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of cell wall organization or biogenesis IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in signal transduction IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in small GTPase-mediated signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in cell division site IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in cell periphery IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cellular bud neck IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in incipient cellular bud site IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
Rho family guanine nucleotide exchange factor TUS1
NP_013529.3
  • Guanine nucleotide exchange factor (GEF) that modulates Rho1p activity; involved in the cell integrity signaling pathway; interacts with Rgl1p; localization of Tus1p to the bed neck is regulated by Rgl1p; multicopy suppressor of tor2 mutation and ypk1 ypk2 double mutation; potential Cdc28p substrate

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001144.5 Reference assembly

    Range
    982894..986817
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001182313.3 → NP_013529.3  TPA: Rho family guanine nucleotide exchange factor TUS1 [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_013529.3

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6VZ61, Q06412
    UniProtKB/TrEMBL
    C7GSM8
    Conserved Domains (2) summary
    smart00036
    Location:939 → 1287
    CNH; Domain found in NIK1-like kinases, mouse citron and yeast ROM1, ROM2
    cd00160
    Location:469 → 655
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q06412.1

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