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CNA1 calcineurin catalytic subunit A [ Saccharomyces cerevisiae S288C ]

Gene ID: 851153, updated on 18-Sep-2024

Summary

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Official Symbol
CNA1
Official Full Name
calcineurin catalytic subunit A
Primary source
SGD:S000004425
Locus tag
YLR433C
See related
AllianceGenome:SGD:S000004425; FungiDB:YLR433C; VEuPathDB:YLR433C
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Also known as
CMP1
Summary
Contributes to calcium-dependent protein serine/threonine phosphatase activity. Involved in adaptation of signaling pathway by response to pheromone involved in conjugation with cellular fusion; cellular ion homeostasis; and fungal-type cell wall organization. Part of calcineurin complex. Human ortholog(s) of this gene implicated in aortic valve stenosis; developmental and epileptic encephalopathy 91; and schizophrenia. Orthologous to human PPP3CA (protein phosphatase 3 catalytic subunit alpha); PPP3CB (protein phosphatase 3 catalytic subunit beta); and PPP3CC (protein phosphatase 3 catalytic subunit gamma). [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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See CNA1 in Genome Data Viewer
Location:
chromosome: XII
Exon count:
1
Sequence:
Chromosome: XII; NC_001144.5 (1004347..1006008, complement)

Chromosome XII - NC_001144.5Genomic Context describing neighboring genes Neighboring gene Atg23p Neighboring gene IMP dehydrogenase IMD3 Neighboring gene Tsr2p Neighboring gene Ecm30p

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001144.5

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. The interaction between the catalytic A subunit of calcineurin and its autoinhibitory domain, in the yeast two-hybrid system, is disrupted by cyclosporin A and FK506. Chaudhuri B, et al. FEBS Lett, 1995 Jan 3. PMID 7528690
  2. Only in the presence of immunophilins can cyclosporin and FK506 disrupt in vivo binding of calcineurin A to its autoinhibitory domain yet strengthen interaction between calcineurin A and B subunits. Chaudhuri B, et al. Biochem Biophys Res Commun, 1995 Oct 13. PMID 7488022
  3. Identification and molecular characterization of the calmodulin-binding subunit gene (CMP1) of protein phosphatase 2B from Saccharomyces cerevisiae. An alpha-factor inducible gene. Ye RR, et al. Eur J Biochem, 1992 Mar 1. PMID 1311678
  4. Solution structures of yeast Saccharomyces cerevisiae calmodulin in calcium- and target peptide-bound states reveal similarities and differences to vertebrate calmodulin. Ogura K, et al. Genes Cells, 2012 Mar. PMID 22280008
  5. Knr4 N-terminal domain controls its localization and function during sexual differentiation and vegetative growth. Dagkessamanskaia A, et al. Yeast, 2010 Aug. PMID 20602333

See all (80) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Data report that heterologous expression of CaZF provides osmotolerance in S. cerevisiae through Hog1p and calcineurin dependent as well as independent pathways.
    Title: CaZF, a plant transcription factor functions through and parallel to HOG and calcineurin pathways in Saccharomyces cerevisiae to provide osmotolerance.
  2. ethanol activates the calcineurin/Crz1 pathway and CRZ1 is crucial for cell survival under ethanol-induced stress
    Title: Ethanol stress stimulates the Ca2+-mediated calcineurin/Crz1 pathway in Saccharomyces cerevisiae.
  3. A conserved docking surface on calcineurin mediates interaction with substrates and immunosuppressants.
    Title: A conserved docking surface on calcineurin mediates interaction with substrates and immunosuppressants.
  4. Results demonstrate that calcineurin can positively regulate the transport of cations by the mutant allele VCX1-M1p.
    Title: Functional dependence on calcineurin by variants of the Saccharomyces cerevisiae vacuolar Ca2+/H+ exchanger Vcx1p.
  5. target of rapamycin complex 2(TORC2)-SLM signaling negatively regulates calcineurin, and calcineurin negatively regulates TORC2-SLM
    Title: Mutual antagonism of target of rapamycin and calcineurin signaling.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
contributes_to calcium-dependent protein serine/threonine phosphatase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables calmodulin binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables calmodulin binding IEA
Inferred from Electronic Annotation
more info
  
enables calmodulin-dependent protein phosphatase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables calmodulin-dependent protein phosphatase activity IEA
Inferred from Electronic Annotation
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables myosin phosphatase activity IEA
Inferred from Electronic Annotation
more info
  
enables phosphoprotein phosphatase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein serine/threonine phosphatase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in calcineurin-mediated signaling IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in calcineurin-mediated signaling IEA
Inferred from Electronic Annotation
more info
  
involved_in cellular response to pheromone IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in conjugation with cellular fusion IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in fungal-type cell wall organization IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in fungal-type cell wall organization IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in intracellular monoatomic ion homeostasis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
part_of calcineurin complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of calcineurin complex IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
calcineurin catalytic subunit A
NP_013537.1
  • Calcineurin A; one isoform (the other is Cmp2p) of the catalytic subunit of calcineurin, a Ca++/calmodulin-regulated protein phosphatase which regulates Crz1p (a stress-response transcription factor), the other calcineurin subunit is CNB1; regulates the function of Aly1p alpha-arrestin; CNA1 has a paralog, CMP2, that arose from the whole genome duplication

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001144.5 Reference assembly

    Range
    1004347..1006008 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001182321.1 → NP_013537.1  TPA: calcineurin catalytic subunit A [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_013537.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6VZ68, P23287
    UniProtKB/TrEMBL
    A7A1V3, B3RHU2, C7GSM2, G2WJP4, N1NZX1
    Conserved Domains (1) summary
    cd07416
    Location:70 → 381
    MPP_PP2B; PP2B, metallophosphatase domain
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P23287.2

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