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PDP3 Pdp3p [ Saccharomyces cerevisiae S288C ]

Gene ID: 851177, updated on 2-Nov-2024

Summary

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Official Symbol
PDP3
Official Full Name
Pdp3p
Primary source
SGD:S000004447
Locus tag
YLR455W
See related
AllianceGenome:SGD:S000004447; FungiDB:YLR455W; VEuPathDB:YLR455W
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary
Enables RNA polymerase II complex binding activity and chromatin binding activity. Involved in positive regulation of transcription elongation by RNA polymerase II. Located in cytosol. Part of NuA3b histone acetyltransferase complex. Is active in nucleus. [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See PDP3 in Genome Data Viewer
Location:
chromosome: XII
Exon count:
1
Sequence:
Chromosome: XII; NC_001144.5 (1053629..1054543)

Chromosome XII - NC_001144.5Genomic Context describing neighboring genes Neighboring gene Fmp27p Neighboring gene tRNA-Ile Neighboring gene pyridoxal 5'-phosphate synthase Neighboring gene Nbp1p

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001144.5

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. NDF is a transcription factor that stimulates elongation by RNA polymerase II. Fei J, et al. Genes Dev, 2022 Mar 1. PMID 35273076, Free PMC Article
  2. The PWWP domain of the human oncogene WHSC1L1/NSD3 induces a metabolic shift toward fermentation. Rona GB, et al. Oncotarget, 2017 Aug 15. PMID 28903324, Free PMC Article
  3. (1) H NMR metabolomics reveals increased glutaminolysis upon overexpression of NSD3s or Pdp3 in Saccharomyces cerevisiae. Rona GB, et al. J Cell Biochem, 2019 Apr. PMID 30320908
  4. Mechanism of selectivity of an angiogenesis inhibitor from screening a genome-wide set of Saccharomyces cerevisiae deletion strains. Dilda PJ, et al. J Natl Cancer Inst, 2005 Oct 19. PMID 16234568
  5. Histone H3K4 and H3K36 Methylation Independently Recruit the NuA3 Histone Acetyltransferase in Saccharomyces cerevisiae. Martin BJ, et al. Genetics, 2017 Mar. PMID 28108585, Free PMC Article

See all (40) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables RNA polymerase II complex binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables chromatin binding IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
involved_in positive regulation of transcription elongation by RNA polymerase II IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in positive regulation of transcription elongation by RNA polymerase II IGI
Inferred from Genetic Interaction
more info
 PubMed 
Component Evidence Code Pubs
part_of NuA3 histone acetyltransferase complex IDA
Inferred from Direct Assay
more info
 PubMed 
part_of NuA3b histone acetyltransferase complex IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cytosol IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in nucleus HDA PubMed 
located_in nucleus HDA PubMed 
is_active_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
Pdp3p
NP_013560.3
  • Component of the NuA3b histone acetyltransferase complex; binds to Pol II and stimulates elongation; regulates interaction between NuA3b and H3K36me3 at transcribed regions of genes; contains PWWP domain; protein abundance increases in response to DNA replication stress; relocalizes to the cytosol in response to hypoxia; extensive sequence similarity (
    25% identity;
    39% similarity) to the N-terminal region of human NDF

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001144.5 Reference assembly

    Range
    1053629..1054543
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001182343.3 → NP_013560.3  TPA: Pdp3p [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_013560.3

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6VZ89, Q06188
    UniProtKB/TrEMBL
    A7A1X6, B3RHW3, C7GUD6, C8ZE61, G2WJR6, N1NZZ1
    Conserved Domains (1) summary
    cd05840
    Location:5 → 96
    SPBC215_ISWI_like; The PWWP domain is a component of the S. pombe hypothetical protein SPBC215, as well as ISWI complex protein 4. The ISWI (imitation switch) proteins are ATPases responsible for chromatin remodeling in eukaryotes, and SPBC215 is proposed to also bind ...
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q06188.1

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