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GAB1 GPI-anchor transamidase subunit GAB1 [ Saccharomyces cerevisiae S288C ]

Gene ID: 851181, updated on 2-Nov-2024

Summary

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Official Symbol
GAB1
Official Full Name
GPI-anchor transamidase subunit GAB1
Primary source
SGD:S000004451
Locus tag
YLR459W
See related
AllianceGenome:SGD:S000004451; FungiDB:YLR459W; VEuPathDB:YLR459W
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Also known as
CDC91
Summary
Involved in attachment of GPI anchor to protein. Located in endoplasmic reticulum. Part of GPI-anchor transamidase complex. Orthologous to human PIGU (phosphatidylinositol glycan anchor biosynthesis class U). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See GAB1 in Genome Data Viewer
Location:
chromosome: XII
Exon count:
1
Sequence:
Chromosome: XII; NC_001144.5 (1057334..1058518)

Chromosome XII - NC_001144.5Genomic Context describing neighboring genes Neighboring gene pyridoxal 5'-phosphate synthase Neighboring gene Nbp1p Neighboring gene uncharacterized protein Neighboring gene seripauperin PAU4

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001144.5

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Deficiencies in the endoplasmic reticulum (ER)-membrane protein Gab1p perturb transfer of glycosylphosphatidylinositol to proteins and cause perinuclear ER-associated actin bar formation. Grimme SJ, et al. Mol Biol Cell, 2004 Jun. PMID 15075373, Free PMC Article
  2. Disulfide Bond Formation and N-Glycosylation Modulate Protein-Protein Interactions in GPI-Transamidase (GPIT). Yi L, et al. Sci Rep, 2017 Apr 4. PMID 28374821, Free PMC Article
  3. Human PIG-U and yeast Cdc91p are the fifth subunit of GPI transamidase that attaches GPI-anchors to proteins. Hong Y, et al. Mol Biol Cell, 2003 May. PMID 12802054, Free PMC Article
  4. A Rab escort protein integrates the secretion system with TOR signaling and ribosome biogenesis. Singh J, et al. Genes Dev, 2009 Aug 15. PMID 19684114, Free PMC Article
  5. The role of the Parkinson's disease gene PARK9 in essential cellular pathways and the manganese homeostasis network in yeast. Chesi A, et al. PLoS One, 2012. PMID 22457822, Free PMC Article

See all (27) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. depletion of Gab1p or Gpi8p, but not Gpi17p, Gpi16p, or Gaa1p causes accumulation of cofilin-decorated actin bars that are closely associated with the perinuclear endoplasmic reticulum
    Title: Deficiencies in the endoplasmic reticulum (ER)-membrane protein Gab1p perturb transfer of glycosylphosphatidylinositol to proteins and cause perinuclear ER-associated actin bar formation.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables molecular_function ND
No biological Data available
more info
  
Process Evidence Code Pubs
involved_in GPI anchor biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
involved_in attachment of GPI anchor to protein IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in attachment of GPI anchor to protein IEA
Inferred from Electronic Annotation
more info
  
involved_in attachment of GPI anchor to protein IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in cell division IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
part_of GPI-anchor transamidase complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of GPI-anchor transamidase complex IEA
Inferred from Electronic Annotation
more info
  
part_of GPI-anchor transamidase complex IMP
Inferred from Mutant Phenotype
more info
 PubMed 
part_of GPI-anchor transamidase complex IPI
Inferred from Physical Interaction
more info
 PubMed 
located_in endoplasmic reticulum HDA PubMed 
located_in endoplasmic reticulum IEA
Inferred from Electronic Annotation
more info
  
located_in endoplasmic reticulum membrane IEA
Inferred from Electronic Annotation
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
GPI-anchor transamidase subunit GAB1
NP_013564.1
  • Subunit of the glycosylphosphatidylinositol transamidase complex; involved in attachment of glycosylphosphatidylinositol (GPI) anchors to proteins; may have a role in recognition of the attachment signal or the lipid portion of GPI; ortholog of human PIGU; partially complements a class U CHO cell line with a mutation in the PIGU ortholog

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001144.5 Reference assembly

    Range
    1057334..1058518
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001182347.1 → NP_013564.1  TPA: GPI-anchor transamidase subunit GAB1 [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_013564.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6VZ92, P41733
    UniProtKB/TrEMBL
    A7A1X9, B3RHW6, B5VNZ8, C7GUD3, C8ZE65, G2WJR9, N1P0B4
    Conserved Domains (1) summary
    pfam06728
    Location:10 → 360
    PIG-U; GPI transamidase subunit PIG-U
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P41733.1

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