TPD3 protein phosphatase 2A structural subunit TPD3 [Saccharomyces cerevisiae S288C] - Gene

Summary

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Official Symbol: TPD3
Official Full Name: protein phosphatase 2A structural subunit TPD3
Primary source: SGD:S000000014
Locus tag: YAL016W
See related: AllianceGenome:SGD:S000000014; FungiDB:YAL016W; VEuPathDB:YAL016W
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Saccharomyces cerevisiae S288C (strain: S288C)
Lineage: Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Also known as: FUN32
Summary: Contributes to protein serine/threonine phosphatase activity. Involved in mitotic spindle assembly checkpoint signaling and regulation of translation. Located in several cellular components, including cellular bud tip; mating projection tip; and spindle pole body. Part of protein phosphatase type 2A complex. Human ortholog(s) of this gene implicated in autosomal dominant intellectual developmental disorder 36 and lung cancer. Orthologous to human PPP2R1A (protein phosphatase 2 scaffold subunit Aalpha) and PPP2R1B (protein phosphatase 2 scaffold subunit Abeta). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See TPD3 in Genome Data Viewer

Location:: chromosome: I

Exon count:: 1

Sequence:: Chromosome: I; NC_001133.9 (124879..126786)

Chromosome I - NC_001133.9 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_001133.9

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

The data support a new model in which adenovirus E4orf4 mediates growth inhibition and cell killing both through PP2A heterotrimers (CDC55, TPD3 C subunit) and through a B (CDC55) regulatory subunit-dependent pathway.
Title: Cdc55p-mediated E4orf4 growth inhibition in Saccharomyces cerevisiae is mediated only in part via the catalytic subunit of protein phosphatase 2A.

Submit: New GeneRIF Correction

Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

Orthologs from OrthoDB

Gene Ontology Provided by SGD

Function	Evidence Code	Pubs
enables protein phosphatase regulator activity	IBA Inferred from Biological aspect of Ancestor more info
contributes_to protein serine/threonine phosphatase activity	IMP Inferred from Mutant Phenotype more info	PubMed

Process	Evidence Code	Pubs
involved_in mitotic spindle assembly checkpoint signaling	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in protein dephosphorylation	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of translation	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in cellular bud neck	IDA Inferred from Direct Assay more info	PubMed
located_in cellular bud tip	IDA Inferred from Direct Assay more info	PubMed
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
is_active_in cytosol	IBA Inferred from Biological aspect of Ancestor more info
located_in mating projection tip	IDA Inferred from Direct Assay more info	PubMed
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed
part_of protein phosphatase type 2A complex	IBA Inferred from Biological aspect of Ancestor more info
part_of protein phosphatase type 2A complex	IDA Inferred from Direct Assay more info	PubMed
located_in spindle pole body	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: protein phosphatase 2A structural subunit TPD3

NP_009386.1

Regulatory subunit A of the heterotrimeric PP2A complex; the heterotrimeric protein phosphatase 2A (PP2A) complex also contains regulatory subunit Cdc55p and either catalytic subunit Pph21p or Pph22p; required for cell morphogenesis and transcription by RNA polymerase III

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_001133.9 Reference assembly

Range

124879..126786

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001178161.1 → NP_009386.1 TPA: protein phosphatase 2A structural subunit TPD3 [Saccharomyces cerevisiae S288C]

See identical proteins and their annotated locations for NP_009386.1

Status: REVIEWED

UniProtKB/Swiss-Prot

D6VPK2, P31383

UniProtKB/TrEMBL

A7A0F3, B3LUV0, B5VDK7, C8Z3L4, G2W8L6, N1P8W8

Conserved Domains (1) summary

sd00044
Location:282 → 306

HEAT; HEAT repeat [structural motif]