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MDM10 Mdm10p [ Saccharomyces cerevisiae S288C ]

Gene ID: 851223, updated on 18-Sep-2024

Summary

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Official Symbol
MDM10
Official Full Name
Mdm10p
Primary source
SGD:S000000008
Locus tag
YAL010C
See related
AllianceGenome:SGD:S000000008; FungiDB:YAL010C; VEuPathDB:YAL010C
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Also known as
FUN37
Summary
Involved in several processes, including establishment of mitochondrion localization; mitochondrion-endoplasmic reticulum membrane tethering; and outer mitochondrial membrane organization. Located in mitochondrial outer membrane. Part of ERMES complex and SAM complex. [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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See MDM10 in Genome Data Viewer
Location:
chromosome: I
Exon count:
1
Sequence:
Chromosome: I; NC_001133.9 (134184..135665, complement)

Chromosome I - NC_001133.9Genomic Context describing neighboring genes Neighboring gene cystathionine gamma-lyase CYS3 Neighboring gene Swc3p Neighboring gene Nem1-Spo7 phosphatase regulatory subunit SPO7 Neighboring gene Fun14p

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001133.9

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Regulation of mitochondrial morphology and inheritance by Mdm10p, a protein of the mitochondrial outer membrane. Sogo LF, et al. J Cell Biol, 1994 Sep. PMID 8089171, Free PMC Article
  2. Mutations in genes encoding the mitochondrial outer membrane proteins Tom70 and Mdm10 of Podospora anserina modify the spectrum of mitochondrial DNA rearrangements associated with cellular death. Jamet-Vierny C, et al. Mol Cell Biol, 1997 Nov. PMID 9343397, Free PMC Article
  3. Mdm10 is an ancient eukaryotic porin co-occurring with the ERMES complex. Flinner N, et al. Biochim Biophys Acta, 2013 Dec. PMID 24135058
  4. Interaction between mitochondria and the actin cytoskeleton in budding yeast requires two integral mitochondrial outer membrane proteins, Mmm1p and Mdm10p. Boldogh I, et al. J Cell Biol, 1998 Jun 15. PMID 9628893, Free PMC Article
  5. Maintenance of mitochondrial morphology is linked to maintenance of the mitochondrial genome in Saccharomyces cerevisiae. Hanekamp T, et al. Genetics, 2002 Nov. PMID 12454062, Free PMC Article

See all (97) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Tom7 recruits Mdm10, enhancing its association with the MMM1 complex, to regulate timing of the release of Tom40 from the TOB complex for subsequent assembly into the TOM40 complex
    Title: Tom7 regulates Mdm10-mediated assembly of the mitochondrial import channel protein Tom40.
  2. Mdm10 regulates the timing of release of unassembled Tom40 from the TOB complex, to facilitate its coordinated assembly into the TOM40 complex
    Title: Mdm10 as a dynamic constituent of the TOB/SAM complex directs coordinated assembly of Tom40.
  3. Tom7-mediated segregation of Mdm10 functions by a differentiation of beta-barrel assembly
    Title: Mitochondrial protein sorting: differentiation of beta-barrel assembly by Tom7-mediated segregation of Mdm10.
Submit: New GeneRIF Correction

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables molecular_function ND
No biological Data available
more info
  
Process Evidence Code Pubs
involved_in establishment of mitochondrion localization IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in establishment of mitochondrion localization IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in mitochondrial genome maintenance IEA
Inferred from Electronic Annotation
more info
  
involved_in mitochondrial outer membrane translocase complex assembly IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in mitochondrial outer membrane translocase complex assembly IEA
Inferred from Electronic Annotation
more info
  
involved_in mitochondrial outer membrane translocase complex assembly IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in mitochondrial outer membrane translocase complex assembly IPI
Inferred from Physical Interaction
more info
 PubMed 
involved_in mitochondrion organization IEA
Inferred from Electronic Annotation
more info
  
involved_in mitochondrion organization IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in mitochondrion-endoplasmic reticulum membrane tethering IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in mitochondrion-endoplasmic reticulum membrane tethering IEA
Inferred from Electronic Annotation
more info
  
involved_in mitochondrion-endoplasmic reticulum membrane tethering IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in peroxisome organization IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in phospholipid transport IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in phospholipid transport IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in protein insertion into mitochondrial outer membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in protein insertion into mitochondrial outer membrane IEA
Inferred from Electronic Annotation
more info
  
involved_in protein insertion into mitochondrial outer membrane IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
part_of ERMES complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of ERMES complex IEA
Inferred from Electronic Annotation
more info
  
part_of ERMES complex IPI
Inferred from Physical Interaction
more info
 PubMed 
part_of SAM complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of SAM complex IPI
Inferred from Physical Interaction
more info
 PubMed 
located_in mitochondrial outer membrane HDA PubMed 
located_in mitochondrial outer membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in mitochondrial outer membrane IEA
Inferred from Electronic Annotation
more info
  
located_in mitochondrion IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
Mdm10p
NP_009392.2
  • Moonlighting protein component of both the ERMES and SAM complex; subunit of the ERMES complex that acts as a molecular tether between the mitochondria and the ER, necessary for both efficient phospholipid exchange between organelles and for mitophagy; SAM/TOB complex subunit that functions in the assembly of outer membrane beta-barrel proteins; involved in mitochondrial inheritance and morphology; ERMES complex often co-localizes with peroxisomes adjacent to mitochondria-ER junctions

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001133.9 Reference assembly

    Range
    134184..135665 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001178155.2 → NP_009392.2  TPA: Mdm10p [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_009392.2

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    A7A0F9, D6VPK8, P18409
    UniProtKB/TrEMBL
    N1PAZ3
    Conserved Domains (1) summary
    pfam12519
    Location:1 → 493
    MDM10; Mitochondrial distribution and morphology protein 10
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P18409.5

Gene LinkOut

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