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SPO7 Nem1-Spo7 phosphatase regulatory subunit SPO7 [ Saccharomyces cerevisiae S288C ]

Gene ID: 851224, updated on 2-Nov-2024

Summary

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Official Symbol
SPO7
Official Full Name
Nem1-Spo7 phosphatase regulatory subunit SPO7
Primary source
SGD:S000000007
Locus tag
YAL009W
See related
AllianceGenome:SGD:S000000007; FungiDB:YAL009W; VEuPathDB:YAL009W
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary
Contributes to phosphoprotein phosphatase activity. Involved in negative regulation of phospholipid biosynthetic process; nuclear envelope organization; and reticulophagy. Located in membrane. Part of Nem1-Spo7 phosphatase complex. [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See SPO7 in Genome Data Viewer
Location:
chromosome: I
Exon count:
1
Sequence:
Chromosome: I; NC_001133.9 (135854..136633)

Chromosome I - NC_001133.9Genomic Context describing neighboring genes Neighboring gene Swc3p Neighboring gene Mdm10p Neighboring gene Fun14p Neighboring gene Erp2p

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001133.9

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Molecular cloning of chromosome I DNA from Saccharomyces cerevisiae: isolation, characterization and regulation of the SPO7 sporulation gene. Whyte W, et al. Gene, 1990 Oct 30. PMID 2253888
  2. Yeast nuclear envelope subdomains with distinct abilities to resist membrane expansion. Campbell JL, et al. Mol Biol Cell, 2006 Apr. PMID 16467382, Free PMC Article
  3. Sequencing of chromosome I from Saccharomyces cerevisiae: analysis of a 32 kb region between the LTE1 and SPO7 genes. Ouellette BF, et al. Genome, 1993 Feb. PMID 8458570
  4. Sequencing of chromosome I of Saccharomyces cerevisiae: analysis of the 42 kbp SPO7-CENI-CDC15 region. Clark MW, et al. Yeast, 1994 Apr. PMID 7941740
  5. Genes controlling meiosis and spore formation in yeast. Esposito MS, et al. Genetics, 1974 Sep. PMID 4613605, Free PMC Article

See all (70) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Phosphorylation-mediated regulation of the Nem1-Spo7/Pah1 phosphatase cascade in yeast lipid synthesis.
    Title: Phosphorylation-mediated regulation of the Nem1-Spo7/Pah1 phosphatase cascade in yeast lipid synthesis.
  2. The Spo7 sequence LLI is required for Nem1-Spo7/Pah1 phosphatase cascade function in yeast lipid metabolism.
    Title: The Spo7 sequence LLI is required for Nem1-Spo7/Pah1 phosphatase cascade function in yeast lipid metabolism.
  3. the TORC1-Nem1/Spo7-Pah1 axis is a master regulator of not only macroautophagy but also microautophagy in budding yeast
    Title: The TORC1-Nem1/Spo7-Pah1/lipin axis regulates microautophagy induction in budding yeast.
  4. Together, our data suggest that Nem1-Sop7-mediated regulation of membrane biogenesis is needed to promote mitophagy in yeast.
    Title: The Nem1-Spo7 protein phosphatase complex is required for efficient mitophagy in yeast.
  5. Acidic tail-dependent binding and dephosphorylation of Pah1p by the Nem1p-Spo7p complex is an important determinant of its function in lipid and membrane biogenesis.
    Title: Regulation of lipid droplet and membrane biogenesis by the acidic tail of the phosphatidate phosphatase Pah1p.
  6. Nuclear envelope phosphatase 1-regulatory subunit 1 (formerly TMEM188) is the metazoan Spo7p ortholog and functions in the lipin activation pathway.
    Title: Nuclear envelope phosphatase 1-regulatory subunit 1 (formerly TMEM188) is the metazoan Spo7p ortholog and functions in the lipin activation pathway.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
contributes_to phosphoprotein phosphatase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
contributes_to phosphoprotein phosphatase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables protein phosphatase regulator activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in lipid metabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in negative regulation of phospholipid biosynthetic process IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in nuclear envelope organization IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in nuclear envelope organization IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of phospholipid biosynthetic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in reticulophagy IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in sporulation resulting in formation of a cellular spore IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
part_of Nem1-Spo7 phosphatase complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of Nem1-Spo7 phosphatase complex IPI
Inferred from Physical Interaction
more info
 PubMed 
located_in endoplasmic reticulum HDA PubMed 
located_in endoplasmic reticulum IEA
Inferred from Electronic Annotation
more info
  
located_in endoplasmic reticulum membrane IEA
Inferred from Electronic Annotation
more info
  
located_in membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
located_in nuclear membrane IEA
Inferred from Electronic Annotation
more info
  
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
Nem1-Spo7 phosphatase regulatory subunit SPO7
NP_009393.1
  • Putative regulatory subunit of Nem1p-Spo7p phosphatase holoenzyme; regulates nuclear/ER membrane association and activation of Pah1p, a phosphatidate phosphatase involved in the production of diacylglycerol DAG for lipid droplet biogenesis; phosphatase activity of the Nem1p-Spo7p complex is inhibited by Ice2p; regulates nuclear growth by controlling phospholipid biosynthesis; required for normal nuclear envelope morphology, premeiotic replication, and sporulation

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001133.9 Reference assembly

    Range
    135854..136633
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001178154.1 → NP_009393.1  TPA: Nem1-Spo7 phosphatase regulatory subunit SPO7 [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_009393.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6VPK9, P18410
    UniProtKB/TrEMBL
    C7GPM5, G2W8M3, N1P934
    Conserved Domains (1) summary
    pfam03907
    Location:45 → 248
    Spo7; Spo7-like protein
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P18410.1

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