U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

GDH3 glutamate dehydrogenase (NADP(+)) GDH3 [ Saccharomyces cerevisiae S288C ]

Gene ID: 851237, updated on 18-Sep-2024

Summary

Go to the top of the page Help
Official Symbol
GDH3
Official Full Name
glutamate dehydrogenase (NADP(+)) GDH3
Primary source
SGD:S000000058
Locus tag
YAL062W
See related
AllianceGenome:SGD:S000000058; FungiDB:YAL062W; VEuPathDB:YAL062W
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Also known as
FUN51
Summary
Enables glutamate dehydrogenase (NADP+) activity. Involved in glutamate biosynthetic process. Located in nucleus. Human ortholog(s) of this gene implicated in familial hyperinsulinemic hypoglycemia 6; hyperinsulinism; hypoglycemia; and late onset Parkinson's disease. Orthologous to human GLUD1 (glutamate dehydrogenase 1) and GLUD2 (glutamate dehydrogenase 2). [provided by Alliance of Genome Resources, Apr 2022]
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
See GDH3 in Genome Data Viewer
Location:
chromosome: I
Exon count:
1
Sequence:
Chromosome: I; NC_001133.9 (31567..32940)

Chromosome I - NC_001133.9Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene flocculin FLO9 Neighboring gene putative dehydrogenase BDH2 Neighboring gene (R,R)-butanediol dehydrogenase

Genomic regions, transcripts, and products

Go to the top of the page Help
Genomic Sequence:
NC_001133.9

Go to nucleotide: Graphics FASTA GenBank

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. Ebselen induces reactive oxygen species (ROS)-mediated cytotoxicity in Saccharomyces cerevisiae with inhibition of glutamate dehydrogenase being a target. Azad GK, et al. FEBS Open Bio, 2014. PMID 24490132, Free PMC Article
  2. Coordinated regulation of ammonium assimilation and carbon catabolism by glyoxylate in Saccharomyces cerevisiae. González A, et al. J Gen Microbiol, 1987 Sep. PMID 2896226
  3. Uptake of ammonia by Saccharomyces cerevisiae carrying the plasmid pCYG4 related with ammonia assimilation. Lima Filho JL, et al. Appl Biochem Biotechnol, 1992 Aug. PMID 1444358
  4. Effects of potassium on the ethanol production rate of Saccharomyces cerevisiae carrying the plasmid pCYG4 related with ammonia assimilation. da Silva NL, et al. Appl Biochem Biotechnol, 1992 Oct. PMID 1288412
  5. Nuclear and cytoplasmic glutamate dehydrogenases (NADP-dependent) in Saccharomyces cerevisiae. Camardella L, et al. Biochem Biophys Res Commun, 1975 May 19. PMID 1096883

See all (45) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. GDH3 is involoved in resistance to stress-induced apoptosis in stationary phase cells.
    Title: Involvement of GDH3-encoded NADP+-dependent glutamate dehydrogenase in yeast cell resistance to stress-induced apoptosis in stationary phase cells.
  2. GDH3 expression is repressed in glucose-grown cultures and induced under respiratory conditions, or under stationary phase. Although GDH3 pertains to the nitrogen metabolic network, its expression is ultimately determined by the carbon source
    Title: Swi/SNF-GCN5-dependent chromatin remodelling determines induced expression of GDH3, one of the paralogous genes responsible for ammonium assimilation and glutamate biosynthesis in Saccharomyces cerevisiae.
Submit: New GeneRIF Correction

Pathways from PubChem

Go to the top of the page

Interactions

Go to the top of the page Help
Products Interactant Other Gene Complex Source Pubs Description

General gene information

Go to the top of the page Help

Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables glutamate dehydrogenase (NADP+) activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables glutamate dehydrogenase (NADP+) activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables glutamate dehydrogenase (NADP+) activity IEA
Inferred from Electronic Annotation
more info
  
enables glutamate dehydrogenase (NADP+) activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables glutamate dehydrogenase [NAD(P)+] activity IEA
Inferred from Electronic Annotation
more info
  
enables oxidoreductase activity IEA
Inferred from Electronic Annotation
more info
  
enables oxidoreductase activity, acting on the CH-NH2 group of donors, NAD or NADP as acceptor IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in amino acid metabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in glutamate biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in glutamate biosynthetic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in mitochondrion HDA PubMed 
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

Go to the top of the page Help
Preferred Names
glutamate dehydrogenase (NADP(+)) GDH3
NP_009339.1
  • NADP(+)-dependent glutamate dehydrogenase; synthesizes glutamate from ammonia and alpha-ketoglutarate; rate of alpha-ketoglutarate utilization differs from Gdh1p; expression regulated by nitrogen and carbon sources; GDH3 has a paralog, GDH1, that arose from the whole genome duplication

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001133.9 Reference assembly

    Range
    31567..32940
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001178204.1 → NP_009339.1  TPA: glutamate dehydrogenase (NADP(+)) GDH3 [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_009339.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6VPF7, P39708
    UniProtKB/TrEMBL
    A7A0A7, B3LUZ4, B5VDG0, C7GPH9, C8Z3M7, G2W8H1, N1P7G4
    Conserved Domains (1) summary
    PRK09414
    Location:4 → 454
    PRK09414; NADP-specific glutamate dehydrogenase
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P39708.1

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Other Literature Sources
Molecular Biology Databases
Research Materials
Tools