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SSA1 Hsp70 family ATPase SSA1 [ Saccharomyces cerevisiae S288C ]

Gene ID: 851259, updated on 29-Jun-2024

Summary

Gene symbol
SSA1
Gene description
Hsp70 family ATPase SSA1
Primary source
FungiDB:YAL005C
Locus tag
YAL005C
See related
SGD:S000000004; AllianceGenome:SGD:S000000004; VEuPathDB:YAL005C
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Also known as
YG100
Summary
Enables ATP hydrolysis activity; tRNA binding activity; and unfolded protein binding activity. Involved in several processes, including cellular protein metabolic process; intracellular protein transport; and protein-containing complex disassembly. Located in fungal-type cell wall; fungal-type vacuole membrane; and nucleus. Part of polysome. Human ortholog(s) of this gene implicated in several diseases, including Kawasaki disease; artery disease (multiple); autoimmune disease of musculoskeletal system (multiple); neurodegenerative disease (multiple); and schizophrenia (multiple). Orthologous to several human genes including HSPA1L (heat shock protein family A (Hsp70) member 1 like); HSPA1B (heat shock protein family A (Hsp70) member 1B); and HSPA8 (heat shock protein family A (Hsp70) member 8). [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

See SSA1 in Genome Data Viewer
Location:
chromosome: I
Exon count:
1
Sequence:
Chromosome: I; NC_001133.9 (139503..141431, complement)

Chromosome I - NC_001133.9Genomic Context describing neighboring genes Neighboring gene Erp2p Neighboring gene tRNA-Pro Neighboring gene translation elongation factor 1 subunit beta Neighboring gene ncRNA Neighboring gene CORVET complex membrane-binding subunit VPS8

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
 
enables ATP hydrolysis activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables ATP hydrolysis activity IDA
Inferred from Direct Assay
more info
PubMed 
enables ATP-dependent protein folding chaperone IEA
Inferred from Electronic Annotation
more info
 
enables heat shock protein binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables protein folding chaperone IBA
Inferred from Biological aspect of Ancestor
more info
 
enables tRNA binding IDA
Inferred from Direct Assay
more info
PubMed 
enables unfolded protein binding IDA
Inferred from Direct Assay
more info
PubMed 
Process Evidence Code Pubs
involved_in SRP-dependent cotranslational protein targeting to membrane, translocation IDA
Inferred from Direct Assay
more info
PubMed 
involved_in cellular response to heat IDA
Inferred from Direct Assay
more info
PubMed 
involved_in chaperone cofactor-dependent protein refolding IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in clathrin coat disassembly IDA
Inferred from Direct Assay
more info
PubMed 
involved_in cytoplasmic translation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in mitochondria-associated ubiquitin-dependent protein catabolic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in proteasome-mediated ubiquitin-dependent protein catabolic process IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in proteasome-mediated ubiquitin-dependent protein catabolic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in protein folding IDA
Inferred from Direct Assay
more info
PubMed 
involved_in protein import into nucleus IDA
Inferred from Direct Assay
more info
PubMed 
involved_in protein import into nucleus IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in protein polyubiquitination IDA
Inferred from Direct Assay
more info
PubMed 
involved_in protein refolding IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in protein refolding IDA
Inferred from Direct Assay
more info
PubMed 
involved_in protein targeting to mitochondrion IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in stress granule disassembly IDA
Inferred from Direct Assay
more info
PubMed 
Component Evidence Code Pubs
located_in cytoplasm HDA PubMed 
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
 
located_in cytosol HDA PubMed 
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in extracellular region IEA
Inferred from Electronic Annotation
more info
 
located_in fungal-type cell wall IDA
Inferred from Direct Assay
more info
PubMed 
located_in fungal-type vacuole membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in nucleus HDA PubMed 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in nucleus IDA
Inferred from Direct Assay
more info
PubMed 
located_in plasma membrane HDA PubMed 
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
 

General protein information

Preferred Names
Hsp70 family ATPase SSA1
NP_009396.2
  • ATPase involved in protein folding and NLS-directed nuclear transport; HSP70 family member; required for ubiquitin-dependent degradation of short-lived proteins; forms a chaperone complex with Ydj1p; localizes to the nucleus, cytoplasm and cell wall; unique functional specificity in the propagation of yeast [URE3] prions and vacuolar-mediated degradation of gluconeogenic enzymes; general targeting factor of Hsp104p to prion fibrils; 98% identity with paralog Ssa2p

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001133.9 Reference assembly

    Range
    139503..141431 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001178151.1NP_009396.2  TPA: Hsp70 family ATPase SSA1 [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_009396.2

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6VPL2, P10591
    UniProtKB/TrEMBL
    A7A0G3, B3LUU3, G2W8M6, G9BX85
    Conserved Domains (1) summary
    PTZ00009
    Location:4642
    PTZ00009; heat shock 70 kDa protein; Provisional