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SWD1 COMPASS subunit protein SWD1 [ Saccharomyces cerevisiae S288C ]

Gene ID: 851265, updated on 2-Nov-2024

Summary

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Official Symbol
SWD1
Official Full Name
COMPASS subunit protein SWD1
Primary source
SGD:S000000064
Locus tag
YAR003W
See related
AllianceGenome:SGD:S000000064; FungiDB:YAR003W; VEuPathDB:YAR003W
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Also known as
CPS50; FUN16; SAF49
Summary
Contributes to histone H3K4 methyltransferase activity. Involved in regulation of DNA-templated transcription; subtelomeric heterochromatin formation; and telomere maintenance. Part of Set1C/COMPASS complex. Orthologous to human RBBP5 (RB binding protein 5, histone lysine methyltransferase complex subunit). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See SWD1 in Genome Data Viewer
Location:
chromosome: I
Exon count:
1
Sequence:
Chromosome: I; NC_001133.9 (155005..156285)

Chromosome I - NC_001133.9Genomic Context describing neighboring genes Neighboring gene FG-nucleoporin NUP60 Neighboring gene Erp1p Neighboring gene replication factor A subunit protein RFA1 Neighboring gene tRNA splicing endonuclease subunit SEN34

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001133.9

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Mitotically heritable, RNA polymerase II-independent H3K4 dimethylation stimulates INO1 transcriptional memory. Sump B, et al. Elife, 2022 May 17. PMID 35579426, Free PMC Article
  2. Tri-methylation of histone H3 lysine 4 facilitates gene expression in ageing cells. Cruz C, et al. Elife, 2018 Oct 2. PMID 30274593, Free PMC Article
  3. Structural basis for COMPASS recognition of an H2B-ubiquitinated nucleosome. Worden EJ, et al. Elife, 2020 Jan 10. PMID 31922488, Free PMC Article
  4. Distinct requirements for the COMPASS core subunits Set1, Swd1, and Swd3 during meiosis in the budding yeast Saccharomyces cerevisiae. Trainor BM, et al. G3 (Bethesda), 2021 Oct 19. PMID 34849786, Free PMC Article
  5. Histone Recycling by FACT and Spt6 during Transcription Prevents the Scrambling of Histone Modifications. Jeronimo C, et al. Cell Rep, 2019 Jul 30. PMID 31365865

See all (109) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Distinct requirements for the COMPASS core subunits Set1, Swd1, and Swd3 during meiosis in the budding yeast Saccharomyces cerevisiae.
    Title: Distinct requirements for the COMPASS core subunits Set1, Swd1, and Swd3 during meiosis in the budding yeast Saccharomyces cerevisiae.
  2. The affinity of the subunit Spp1 for modified histone H3 substrates is much higher than that of Swd1 and Swd3.
    Title: Characterising the binding specificities of the subunits associated with the KMT2/Set1 histone lysine methyltransferase.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
contributes_to histone H3K4 methyltransferase activity IDA
Inferred from Direct Assay
more info
 PubMed 
contributes_to histone H3K4 methyltransferase activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Process Evidence Code Pubs
involved_in regulation of DNA-templated transcription IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in subtelomeric heterochromatin formation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in telomere maintenance IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
part_of Set1C/COMPASS complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of Set1C/COMPASS complex IEA
Inferred from Electronic Annotation
more info
  
part_of Set1C/COMPASS complex IPI
Inferred from Physical Interaction
more info
 PubMed 
located_in chromosome IEA
Inferred from Electronic Annotation
more info
  
located_in chromosome, telomeric region IEA
Inferred from Electronic Annotation
more info
  
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
COMPASS subunit protein SWD1
NP_009403.1
  • Subunit of the COMPASS (Set1C) complex; COMPASS methylates histone H3 on lysine 4 and is required in transcriptional silencing near telomeres; WD40 beta propeller superfamily member with similarity to mammalian Rbbp7

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001133.9 Reference assembly

    Range
    155005..156285
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001178210.1 → NP_009403.1  TPA: COMPASS subunit protein SWD1 [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_009403.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6VPL8, P39706
    UniProtKB/TrEMBL
    A7A0G9, B3LUT7, C7GTB4, C8Z3I0, G2W8N2, N1PAZ5
    Conserved Domains (2) summary
    sd00039
    Location:31 → 63
    7WD40; WD40 repeat [structural motif]
    cl29593
    Location:10 → 341
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P39706.1

Gene LinkOut

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