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BUD14 protein phosphatase regulator BUD14 [ Saccharomyces cerevisiae S288C ]

Gene ID: 851271, updated on 18-Sep-2024

Summary

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Official Symbol
BUD14
Official Full Name
protein phosphatase regulator BUD14
Primary source
SGD:S000000069
Locus tag
YAR014C
See related
AllianceGenome:SGD:S000000069; FungiDB:YAR014C; VEuPathDB:YAR014C
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary
Enables protein phosphatase regulator activity. Involved in several processes, including regulation of actin filament organization; regulation of cell shape; and regulation of cytokinesis. Located in cellular bud neck and cellular bud tip. Part of Kelch-containing formin regulatory complex and incipient cellular bud site. [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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See BUD14 in Genome Data Viewer
Location:
chromosome: I
Exon count:
1
Sequence:
Chromosome: I; NC_001133.9 (166742..168871, complement)

Chromosome I - NC_001133.9Genomic Context describing neighboring genes Neighboring gene gag protein Neighboring gene tRNA-Ala Neighboring gene phosphoribosylaminoimidazolesuccinocarboxamide synthase Neighboring gene serine/threonine protein kinase KIN3

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001133.9

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Differential genetic interactions of yeast stress response MAPK pathways. Martin H, et al. Mol Syst Biol, 2015 Apr 17. PMID 25888283, Free PMC Article
  2. The Glc7p-interacting protein Bud14p attenuates polarized growth, pheromone response, and filamentous growth in Saccharomyces cerevisiae. Cullen PJ, et al. Eukaryot Cell, 2002 Dec. PMID 12477789, Free PMC Article
  3. Common formin-regulating sequences in Smy1 and Bud14 are required for the control of actin cable assembly in vivo. Eskin JA, et al. Mol Biol Cell, 2016 Mar 1. PMID 26764093, Free PMC Article
  4. The myosin passenger protein Smy1 controls actin cable structure and dynamics by acting as a formin damper. Chesarone-Cataldo M, et al. Dev Cell, 2011 Aug 16. PMID 21839918, Free PMC Article
  5. Saccharomyces cerevisiae Kelch proteins and Bud14 protein form a stable 520-kDa formin regulatory complex that controls actin cable assembly and cell morphogenesis. Gould CJ, et al. J Biol Chem, 2014 Jun 27. PMID 24828508, Free PMC Article

See all (65) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Protein phosphatase 1 in association with Bud14 inhibits mitotic exit in Saccharomyces cerevisiae.
    Title: Protein phosphatase 1 in association with Bud14 inhibits mitotic exit in Saccharomyces cerevisiae.
  2. Formin-regulating sequences in Smy1 and Bud14 are required for the control of actin cable assembly.
    Title: Common formin-regulating sequences in Smy1 and Bud14 are required for the control of actin cable assembly in vivo.
  3. Bud14, Kel1, and Kel2 interact to form a stable 520-kDa complex that controls actin cable assembly and cell morphogenesis.
    Title: Saccharomyces cerevisiae Kelch proteins and Bud14 protein form a stable 520-kDa formin regulatory complex that controls actin cable assembly and cell morphogenesis.
  4. formin displacement from growing barbed ends by bud14 is critical for actin cable architecture and function
    Title: Displacement of formins from growing barbed ends by bud14 is critical for actin cable architecture and function.
  5. the Ccr4-Not complex independently controls TFIID promoter distribution and Msn2-dependent trans-activation through a process involving a Glc7/Bud14 phosphatase
    Title: The Ccr4-Not complex independently controls both Msn2-dependent transcriptional activation--via a newly identified Glc7/Bud14 type I protein phosphatase module--and TFIID promoter distribution.
  6. Bud14p functions as a regulatory subunit of the Glc7p type-I phosphatase to stabilize MT interactions specifically at sites of polarized growth.
    Title: The Bud14p-Glc7p complex functions as a cortical regulator of dynein in budding yeast.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables protein phosphatase regulator activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables protein phosphatase regulator activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Process Evidence Code Pubs
involved_in cell division IEA
Inferred from Electronic Annotation
more info
  
involved_in cytoskeleton organization IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in establishment or maintenance of actin cytoskeleton polarity IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in negative regulation of actin filament polymerization IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in negative regulation of actin filament polymerization IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in negative regulation of actin filament polymerization IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in negative regulation of exit from mitosis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in protein localization IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of DNA-templated transcription IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in regulation of DNA-templated transcription IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of cell shape IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in regulation of cytokinesis IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in regulation of formin-nucleated actin cable assembly IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in regulation of protein localization IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in regulation of vesicle-mediated transport IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
part_of Kelch-containing formin regulatory complex IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in cell tip IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cellular bud neck IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cellular bud tip IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cytoplasm HDA PubMed 
located_in incipient cellular bud site IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in microtubule cytoskeleton IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in nucleus HDA PubMed 
located_in nucleus HDA PubMed 

General protein information

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Preferred Names
protein phosphatase regulator BUD14
NP_009408.3
  • Protein involved in bud-site selection; Bud14p-Glc7p complex is a cortical regulator of dynein; forms a complex with Kel1p and Kel2p that regulates Bnr1p (formin) to affect actin cable assembly, cytokinesis, and polarized growth; diploid mutants display a random budding pattern instead of the wild-type bipolar pattern; relative distribution to the nucleus increases upon DNA replication stress

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001133.9 Reference assembly

    Range
    166742..168871 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001178215.2 → NP_009408.3  TPA: protein phosphatase regulator BUD14 [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_009408.3

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6VPM3, P27637
    UniProtKB/TrEMBL
    A7A0H2, C7GUF5, N1P8X7
    Conserved Domains (1) summary
    pfam00018
    Location:266 → 312
    SH3_1; SH3 domain
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P27637.4

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