U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

SWH1 oxysterol-binding protein related protein SWH1 [ Saccharomyces cerevisiae S288C ]

Gene ID: 851286, updated on 18-Sep-2024

Summary

Go to the top of the page Help
Official Symbol
SWH1
Official Full Name
oxysterol-binding protein related protein SWH1
Primary source
SGD:S000000081
Locus tag
YAR042W
See related
AllianceGenome:SGD:S000000081; FungiDB:YAR042W; VEuPathDB:YAR042W
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Also known as
OSH1; YAR044W
Summary
Enables lipid binding activity and sterol transfer activity. Involved in several processes, including maintenance of cell polarity; piecemeal microautophagy of the nucleus; and sterol transport. Located in several cellular components, including Golgi trans cisterna; early endosome; and nucleus-vacuole junction. Orthologous to several human genes including OSBP (oxysterol binding protein) and OSBP2 (oxysterol binding protein 2). [provided by Alliance of Genome Resources, Apr 2022]
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
See SWH1 in Genome Data Viewer
Location:
chromosome: I
Exon count:
1
Sequence:
Chromosome: I; NC_001133.9 (192619..196185)

Chromosome I - NC_001133.9Genomic Context describing neighboring genes Neighboring gene carnitine O-acetyltransferase YAT1 Neighboring gene uncharacterized protein Neighboring gene flocculin FLO1 Neighboring gene pseudo

Genomic regions, transcripts, and products

Go to the top of the page Help
Genomic Sequence:
NC_001133.9

Go to nucleotide: Graphics FASTA GenBank

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. The pleckstrin homology domain of oxysterol-binding protein recognises a determinant specific to Golgi membranes. Levine TP, et al. Curr Biol, 1998 Jun 18. PMID 9651677
  2. SWH1 from yeast encodes a candidate nuclear factor containing ankyrin repeats and showing homology to mammalian oxysterol-binding protein. Schmalix WA, et al. Biochim Biophys Acta, 1994 Sep 13. PMID 8086466
  3. Saccharomyces cerevisiae FLO1 Gene Demonstrates Genetic Linkage to Increased Fermentation Rate at Low Temperatures. Deed RC, et al. G3 (Bethesda), 2017 Mar 10. PMID 28143947, Free PMC Article
  4. Multiple pools of phosphatidylinositol 4-phosphate detected using the pleckstrin homology domain of Osh2p. Roy A, et al. J Biol Chem, 2004 Oct 22. PMID 15271978
  5. Structure and function of nucleus-vacuole junctions: outer-nuclear-membrane targeting of Nvj1p and a role in tryptophan uptake. Kvam E, et al. J Cell Sci, 2006 Sep 1. PMID 16912077

See all (71) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. ORP/Osh mediate cross-talk between ER-plasma membrane contact site components and plasma membrane SNAREs.
    Title: ORP/Osh mediate cross-talk between ER-plasma membrane contact site components and plasma membrane SNAREs.
  2. Nvj1p is the outer-nuclear-membrane receptor for oxysterol-binding protein homolog Osh1p in Saccharomyces cerevisiae
    Title: Nvj1p is the outer-nuclear-membrane receptor for oxysterol-binding protein homolog Osh1p in Saccharomyces cerevisiae.
Submit: New GeneRIF Correction

Interactions

Go to the top of the page Help
Products Interactant Other Gene Complex Source Pubs Description

General gene information

Go to the top of the page Help

Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables lipid binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables lipid binding IEA
Inferred from Electronic Annotation
more info
  
enables sterol binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables sterol transfer activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables sterol transfer activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in endocytosis IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in endocytosis IEA
Inferred from Electronic Annotation
more info
  
involved_in endocytosis IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in exocytosis IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in exocytosis IEA
Inferred from Electronic Annotation
more info
  
involved_in exocytosis IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in lipid transport IEA
Inferred from Electronic Annotation
more info
  
involved_in maintenance of cell polarity IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in maintenance of cell polarity IEA
Inferred from Electronic Annotation
more info
  
involved_in maintenance of cell polarity IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in piecemeal microautophagy of the nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in piecemeal microautophagy of the nucleus IEA
Inferred from Electronic Annotation
more info
  
involved_in piecemeal microautophagy of the nucleus IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in sterol transport IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in sterol transport IGI
Inferred from Genetic Interaction
more info
 PubMed 
Component Evidence Code Pubs
located_in Golgi apparatus IEA
Inferred from Electronic Annotation
more info
  
located_in Golgi membrane IEA
Inferred from Electronic Annotation
more info
  
located_in Golgi trans cisterna IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in early endosome IDA
Inferred from Direct Assay
more info
 PubMed 
located_in endoplasmic reticulum IDA
Inferred from Direct Assay
more info
 PubMed 
located_in endoplasmic reticulum IEA
Inferred from Electronic Annotation
more info
  
located_in endoplasmic reticulum membrane IEA
Inferred from Electronic Annotation
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
is_active_in nuclear envelope IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nuclear envelope IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nuclear outer membrane IEA
Inferred from Electronic Annotation
more info
  
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  
located_in nucleus-vacuole junction IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in perinuclear endoplasmic reticulum IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in vacuolar membrane IEA
Inferred from Electronic Annotation
more info
  
located_in vacuole IEA
Inferred from Electronic Annotation
more info
  

General protein information

Go to the top of the page Help
Preferred Names
oxysterol-binding protein related protein SWH1
NP_009421.3
  • Protein similar to mammalian oxysterol-binding protein; contains ankyrin repeats and FFAT motif; interacts with ER anchor Scs2p at the nucleus-vacuole junction; regulated by sterol binding; SWH1 has a paralog, OSH2, that arose from the whole genome duplication

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001133.9 Reference assembly

    Range
    192619..196185
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001178227.1 → NP_009421.3  TPA: oxysterol-binding protein related protein SWH1 [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_009421.3

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6VPN6, P35845, P39555, P80234, Q86ZC4, Q86ZS1
    UniProtKB/TrEMBL
    A7A0I6, C7GJW7, C8Z3J5
    Conserved Domains (7) summary
    COG0666
    Location:89 → 181
    ANKYR; Ankyrin repeat [Signal transduction mechanisms]
    cd13292
    Location:281 → 383
    PH_Osh1p_Osh2p_yeast; Yeast oxysterol binding protein homologs 1 and 2 Pleckstrin homology (PH) domain
    TIGR02169
    Location:562 → 774
    SMC_prok_A; chromosome segregation protein SMC, primarily archaeal type
    sd00045
    Location:56 → 94
    ANK; ANK repeat [structural motif]
    pfam13637
    Location:56 → 117
    Ank_4; Ankyrin repeats (many copies)
    pfam00023
    Location:197 → 228
    Ank; Ankyrin repeat
    pfam01237
    Location:800 → 1174
    Oxysterol_BP; Oxysterol-binding protein
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P35845.4

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Other Literature Sources
Molecular Biology Databases
Research Materials
Tools
Miscellaneous