RRI1 COP9 signalosome catalytic subunit RRI1 [Saccharomyces cerevisiae S288C] - Gene

Summary

Official Symbol: RRI1
Official Full Name: COP9 signalosome catalytic subunit RRI1
Primary source: SGD:S000002375
Locus tag: YDL216C
See related: AllianceGenome:SGD:S000002375; FungiDB:YDL216C; VEuPathDB:YDL216C
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Saccharomyces cerevisiae S288C (strain: S288C)
Lineage: Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Also known as: CSN5; JAB1
Summary: Enables metalloendopeptidase activity. Involved in several processes, including cellular response to pheromone; positive regulation of ergosterol biosynthetic process; and protein deneddylation. Part of COP9 signalosome. Orthologous to human COPS5 (COP9 signalosome subunit 5). [provided by Alliance of Genome Resources, Nov 2024]
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Chromosome IV - NC_001136.10 Genomic Context describing neighboring genes

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The COP9 signalosome mediates the Spt23 regulated fatty acid desaturation and ergosterol biosynthesis.
Title: The COP9 signalosome mediates the Spt23 regulated fatty acid desaturation and ergosterol biosynthesis.

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

Function	Evidence Code	Pubs
enables deNEDDylase activity	IBA Inferred from Biological aspect of Ancestor more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables metalloendopeptidase activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables metallopeptidase activity	IBA Inferred from Biological aspect of Ancestor more info
enables metallopeptidase activity	IEA Inferred from Electronic Annotation more info
enables zinc ion binding	RCA inferred from Reviewed Computational Analysis more info	PubMed

Process	Evidence Code	Pubs
involved_in cellular response to pheromone	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in conjugation with cellular fusion	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of ergosterol biosynthetic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in protein deneddylation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in proteolysis	IEA Inferred from Electronic Annotation more info
involved_in regulation of cell cycle	IBA Inferred from Biological aspect of Ancestor more info
involved_in reproductive process	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
part_of COP9 signalosome	IBA Inferred from Biological aspect of Ancestor more info
part_of COP9 signalosome	IDA Inferred from Direct Assay more info	PubMed
part_of COP9 signalosome	IEA Inferred from Electronic Annotation more info
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in nucleus	IEA Inferred from Electronic Annotation more info

NP_010065.2

Catalytic subunit of the COP9 signalosome (CSN) complex; acts as an isopeptidase in cleaving the ubiquitin-like protein Nedd8 from SCF ubiquitin ligases; metalloendopeptidase involved in the adaptation to pheromone signaling; involved in modulation of genes controlling amino acid and lipid metabolism, and ergosterol biosynthesis

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The following sections contain reference sequences that belong to a specific genome build. Explain