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SHR3 Shr3p [ Saccharomyces cerevisiae S288C ]

Gene ID: 851314, updated on 1-Aug-2024

Summary

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Gene symbol
SHR3
Gene description
Shr3p
Primary source
FungiDB:YDL212W
Locus tag
YDL212W
See related
SGD:S000002371; AllianceGenome:SGD:S000002371; VEuPathDB:YDL212W
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Also known as
APF1
Summary
Enables unfolded protein binding activity. Involved in COPII-coated vesicle budding and protein folding. Is integral component of endoplasmic reticulum membrane. [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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See SHR3 in Genome Data Viewer
Location:
chromosome: IV
Exon count:
1
Sequence:
Chromosome: IV; NC_001136.10 (78426..79058)

Chromosome IV - NC_001136.10Genomic Context describing neighboring genes Neighboring gene serine/threonine protein kinase PRR2 Neighboring gene Nop6p Neighboring gene uncharacterized protein Neighboring gene tRNA-Gly

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001136.10

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Amino acid permeases require COPII components and the ER resident membrane protein Shr3p for packaging into transport vesicles in vitro. Kuehn MJ, et al. J Cell Biol, 1996 Nov. PMID 8909535, Free PMC Article
  2. Functional analysis of apf1 mutation causing defective amino acid transport in Saccharomyces cerevisiae. Horák J, et al. Biochem Mol Biol Int, 1993 Apr. PMID 8389634
  3. Mutation affecting activity of several distinct amino acid transport systems in Saccharomyces cerevisiae. Grenson M, et al. J Bacteriol, 1971 Feb. PMID 5541525, Free PMC Article
  4. SHR3: a novel component of the secretory pathway specifically required for localization of amino acid permeases in yeast. Ljungdahl PO, et al. Cell, 1992 Oct 30. PMID 1423607
  5. Ssy1 functions at the plasma membrane as a receptor of extracellular amino acids independent of plasma membrane-endoplasmic reticulum junctions. Ring A, et al. Traffic, 2019 Oct. PMID 31336002

See all (50) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. ER-localized Shr3 is a selective co-translational folding chaperone necessary for amino acid permease biogenesis.
    Title: ER-localized Shr3 is a selective co-translational folding chaperone necessary for amino acid permease biogenesis.
  2. Data show that the membrane domain of Shr3p prevents amino acid permeases (AAPs) from aggregating, and plays a critical role in assisting AAPs to fold and attain tertiary structures required for ER exit.
    Title: Specialized membrane-localized chaperones prevent aggregation of polytopic proteins in the ER.
  3. Shr3 prevents aggregation and facilitates the functional assembly of independently coexpressed N- and C-terminal fragments of the general AAP Gap1.
    Title: Membrane chaperone Shr3 assists in folding amino acid permeases preventing precocious ERAD.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables unfolded protein binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables unfolded protein binding IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Process Evidence Code Pubs
involved_in COPII-coated vesicle budding IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in endoplasmic reticulum to Golgi vesicle-mediated transport IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in protein folding IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in protein transport IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in endoplasmic reticulum HDA PubMed 
located_in endoplasmic reticulum IEA
Inferred from Electronic Annotation
more info
  
is_active_in endoplasmic reticulum membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in endoplasmic reticulum membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in endoplasmic reticulum membrane IEA
Inferred from Electronic Annotation
more info
  
located_in mating projection tip HDA PubMed 
located_in membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
Shr3p
NP_010069.1
  • Endoplasmic reticulum packaging chaperone; required for incorporation of amino acid permeases into COPII coated vesicles for transport to the cell surface

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001136.10 Reference assembly

    Range
    78426..79058
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001180272.1 → NP_010069.1  TPA: Shr3p [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_010069.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6VRE2, Q02774, Q12413
    UniProtKB/TrEMBL
    A6ZXC1, B3LH92, B5VF64, C7GSW5, C8Z6Q7, G2WBV5, N1P862
    Conserved Domains (1) summary
    pfam08229
    Location:6 → 188
    SHR3_chaperone; ER membrane protein SH3
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q02774.2

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