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RTN2 Rtn2p [ Saccharomyces cerevisiae S288C ]

Gene ID: 851323, updated on 2-Nov-2024

Summary

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Official Symbol
RTN2
Official Full Name
Rtn2p
Primary source
SGD:S000002363
Locus tag
YDL204W
See related
AllianceGenome:SGD:S000002363; FungiDB:YDL204W; VEuPathDB:YDL204W
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary
Involved in ER-dependent peroxisome organization; endoplasmic reticulum organization; and response to endoplasmic reticulum stress. Located in cortical endoplasmic reticulum. [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See RTN2 in Genome Data Viewer
Location:
chromosome: IV
Exon count:
1
Sequence:
Chromosome: IV; NC_001136.10 (94605..95786)

Chromosome IV - NC_001136.10Genomic Context describing neighboring genes Neighboring gene hydroxymethylbilane synthase Neighboring gene uncharacterized protein Neighboring gene Ack1p Neighboring gene mitochondrial 54S ribosomal protein YmL11

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001136.10

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. High-curvature domains of the ER are important for the organization of ER exit sites in Saccharomyces cerevisiae. Okamoto M, et al. J Cell Sci, 2012 Jul 15. PMID 22467862
  2. A 3D analysis of yeast ER structure reveals how ER domains are organized by membrane curvature. West M, et al. J Cell Biol, 2011 Apr 18. PMID 21502358, Free PMC Article
  3. Membrane-shaping host reticulon proteins play crucial roles in viral RNA replication compartment formation and function. Diaz A, et al. Proc Natl Acad Sci U S A, 2010 Sep 14. PMID 20805477, Free PMC Article
  4. The reticulon and DP1/Yop1p proteins form immobile oligomers in the tubular endoplasmic reticulum. Shibata Y, et al. J Biol Chem, 2008 Jul 4. PMID 18442980, Free PMC Article
  5. Membrane proteins of the endoplasmic reticulum induce high-curvature tubules. Hu J, et al. Science, 2008 Feb 29. PMID 18309084

See all (63) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables molecular_function ND
No biological Data available
more info
  
Process Evidence Code Pubs
involved_in ER-dependent peroxisome organization IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in endoplasmic reticulum inheritance IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in endoplasmic reticulum tubular network maintenance IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in endoplasmic reticulum tubular network organization IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in response to endoplasmic reticulum stress IGI
Inferred from Genetic Interaction
more info
 PubMed 
Component Evidence Code Pubs
located_in cell periphery HDA PubMed 
located_in cortical endoplasmic reticulum IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cytoplasm HDA PubMed 
located_in endoplasmic reticulum HDA PubMed 
located_in endoplasmic reticulum IEA
Inferred from Electronic Annotation
more info
  
located_in endoplasmic reticulum membrane IEA
Inferred from Electronic Annotation
more info
  
located_in endoplasmic reticulum tubular network IDA
Inferred from Direct Assay
more info
 PubMed 
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
located_in nucleus HDA PubMed 

General protein information

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Preferred Names
Rtn2p
NP_010077.1
  • Reticulon protein; involved in nuclear pore assembly and maintenance of tubular ER morphology; promotes membrane curvature; regulates the ER asymmetry-induced inheritance block during ER stress; role in ER-derived peroxisomal biogenesis; interacts with Sec6p, Yip3p, and Sbh1p; less abundant than RTN1; member of RTNLA (reticulon-like A) subfamily; protein increases in abundance and relocalizes to plasma membrane upon DNA replication stress

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001136.10 Reference assembly

    Range
    94605..95786
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001180264.1 → NP_010077.1  TPA: Rtn2p [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_010077.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6VRF0, Q12443
    UniProtKB/TrEMBL
    B3LH84, C7GV65, G2WBW3, N1PAF0
    Conserved Domains (1) summary
    pfam02453
    Location:33 → 188
    Reticulon
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q12443.1

Gene LinkOut

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