U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

RBS1 Rbs1p [ Saccharomyces cerevisiae S288C ]

Gene ID: 851338, updated on 18-Sep-2024

Summary

Go to the top of the page Help
Official Symbol
RBS1
Official Full Name
Rbs1p
Primary source
SGD:S000002348
Locus tag
YDL189W
See related
AllianceGenome:SGD:S000002348; FungiDB:YDL189W; VEuPathDB:YDL189W
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary
Predicted to enable RNA binding activity. Involved in RNA polymerase III assembly and galactose metabolic process. Located in nucleus. Orthologous to several human genes including R3HDM2 (R3H domain containing 2). [provided by Alliance of Genome Resources, Apr 2022]
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
See RBS1 in Genome Data Viewer
Location:
chromosome: IV
Exon count:
1
Sequence:
Chromosome: IV; NC_001136.10 (122216..123589)

Chromosome IV - NC_001136.10Genomic Context describing neighboring genes Neighboring gene ribosomal 60S subunit protein L35A Neighboring gene ubiquitin-ubiquitin ligase UFD2 Neighboring gene phosphoprotein phosphatase 2A catalytic subunit PPH22 Neighboring gene uncharacterized protein

Genomic regions, transcripts, and products

Go to the top of the page Help
Genomic Sequence:
NC_001136.10

Go to nucleotide: Graphics FASTA GenBank

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. Rbs1 protein, involved in RNA polymerase III complex assembly in the yeast Saccharomyces cerevisiae, induces a Gcn4 response and forms aggregates when overproduced. Rudzińska I, et al. Gene, 2022 Jan 30. PMID 34688816
  2. Reprogramming mRNA Expression in Response to Defect in RNA Polymerase III Assembly in the Yeast Saccharomyces cerevisiae. Rudzińska I, et al. Int J Mol Sci, 2021 Jul 7. PMID 34298922, Free PMC Article
  3. Coupling of RNA polymerase III assembly to cell cycle progression in Saccharomyces cerevisiae. Płonka M, et al. Cell Cycle, 2019 Feb. PMID 30760101, Free PMC Article
  4. The expression of Rpb10, a small subunit common to RNA polymerases, is modulated by the R3H domain-containing Rbs1 protein and the Upf1 helicase. Cieśla M, et al. Nucleic Acids Res, 2020 Dec 2. PMID 33231687, Free PMC Article
  5. Rbs1, a new protein implicated in RNA polymerase III biogenesis in yeast Saccharomyces cerevisiae. Cieśla M, et al. Mol Cell Biol, 2015 Apr. PMID 25605335, Free PMC Article

See all (31) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Rbs1 protein, involved in RNA polymerase III complex assembly in the yeast Saccharomyces cerevisiae, induces a Gcn4 response and forms aggregates when overproduced.
    Title: Rbs1 protein, involved in RNA polymerase III complex assembly in the yeast Saccharomyces cerevisiae, induces a Gcn4 response and forms aggregates when overproduced.
  2. The expression of Rpb10, a small subunit common to RNA polymerases, is modulated by the R3H domain-containing Rbs1 protein and the Upf1 helicase.
    Title: The expression of Rpb10, a small subunit common to RNA polymerases, is modulated by the R3H domain-containing Rbs1 protein and the Upf1 helicase.
  3. Rbs1 physically interacts with a subset of Pol III subunits, AC19, AC40, and ABC27/Rpb5. Rbs1 binds to the Pol III complex or subcomplex and facilitates its translocation to the nucleus.
    Title: Rbs1, a new protein implicated in RNA polymerase III biogenesis in yeast Saccharomyces cerevisiae.
Submit: New GeneRIF Correction

Interactions

Go to the top of the page Help
Products Interactant Other Gene Complex Source Pubs Description

General gene information

Go to the top of the page Help

Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables RNA binding IEA
Inferred from Electronic Annotation
more info
  
enables mRNA 5'-UTR binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables nucleic acid binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in RNA polymerase III assembly IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in galactose metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in galactose metabolic process IGI
Inferred from Genetic Interaction
more info
 PubMed 
Component Evidence Code Pubs
located_in cytoplasm HDA PubMed 
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
is_active_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

Go to the top of the page Help
Preferred Names
Rbs1p
NP_010092.2
  • Protein involved in assembly of the RNA Pol III complex; high copy suppressor of Pol III assembly mutation and psk1 psk2 mutations that confer temperature-sensitivity for galactose utilization; physically interacts with Pol III; proposed to bind single-stranded nucleic acids via its R3H domain; capable of forming the prion [VTS1+]

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001136.10 Reference assembly

    Range
    122216..123589
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001180249.1 → NP_010092.2  TPA: Rbs1p [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_010092.2

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6VRG4, Q05672, Q06896, Q07619, Q870H2
    UniProtKB/TrEMBL
    G2WBX7
    Conserved Domains (1) summary
    cd02642
    Location:25 → 85
    R3H_encore_like; R3H domain of encore-like and DIP1-like proteins. Drosophila encore is involved in the germline exit after four mitotic divisions, by facilitating SCF-ubiquitin-proteasome-dependent proteolysis. Maize DBF1-interactor protein 1 (DIP1) containing an R3H ...
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q05672.1

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Other Literature Sources
Molecular Biology Databases
Research Materials
Tools