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VMA1 H(+)-transporting V1 sector ATPase subunit A [ Saccharomyces cerevisiae S288C ]

Gene ID: 851342, updated on 3-Nov-2024

Summary

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Official Symbol
VMA1
Official Full Name
H(+)-transporting V1 sector ATPase subunit A
Primary source
SGD:S000002344
Locus tag
YDL185W
See related
AllianceGenome:SGD:S000002344; FungiDB:YDL185W; VEuPathDB:YDL185W
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Also known as
CLS8; TFP1
Summary
Enables proton-transporting ATPase activity, rotational mechanism. Involved in vacuolar acidification. Located in fungal-type vacuole membrane. Part of vacuolar proton-transporting V-type ATPase, V1 domain. Human ortholog(s) of this gene implicated in autosomal recessive cutis laxa type IID and developmental and epileptic encephalopathy 93. Orthologous to human ATP6V1A (ATPase H+ transporting V1 subunit A). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See VMA1 in Genome Data Viewer
Location:
chromosome: IV
Exon count:
1
Sequence:
Chromosome: IV; NC_001136.10 (126787..130002)

Chromosome IV - NC_001136.10Genomic Context describing neighboring genes Neighboring gene phosphoprotein phosphatase 2A catalytic subunit PPH22 Neighboring gene uncharacterized protein Neighboring gene ribosomal 60S subunit protein L41A Neighboring gene Mrx19p

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001136.10

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Photoaffinity labeling of wild-type and mutant forms of the yeast V-ATPase A subunit by 2-azido-[(32)P]ADP. MacLeod KJ, et al. J Biol Chem, 1999 Nov 12. PMID 10551850
  2. Substrate recognition and induced DNA distortion by the PI-SceI endonuclease, an enzyme generated by protein splicing. Gimble FS, et al. J Mol Biol, 1996 Oct 25. PMID 8913299
  3. Binding, bending and cleavage of DNA substrates by the homing endonuclease Pl-SceI. Wende W, et al. Nucleic Acids Res, 1996 Nov 1. PMID 8932361, Free PMC Article
  4. Crystal structure of PI-SceI, a homing endonuclease with protein splicing activity. Duan X, et al. Cell, 1997 May 16. PMID 9160747
  5. Probing novel elements for protein splicing in the yeast Vma1 protozyme: a study of replacement mutagenesis and intragenic suppression. Nogami S, et al. Genetics, 1997 Sep. PMID 9286669, Free PMC Article

See all (215) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Loss of function of the vacuolar H-ATPase (vma1) or a defect in the biosynthesis of the osmolyte glycerol (gpd1) caused a prolonged repression of housekeeping genes and a delay in gene activation and adaptation towards salt stress.
    Title: Coordinated gene regulation in the initial phase of salt stress adaptation.
  2. recruitment of Dmc1p and Rad51p to the TFP1-induced double-strand break repair site
    Title: Recruitment of RecA homologs Dmc1p and Rad51p to the double-strand break repair site initiated by meiosis-specific endonuclease VDE (PI-SceI).
  3. Study suggests that nucleosome positioning or occupancy around the VDE recognition site by itself is not the sole mechanism for the regulation of meiosis-specific DNA cleavage by VDE and that other mechanisms are involved in the regulation.
    Title: Investigation of the mechanism of meiotic DNA cleavage by VMA1-derived endonuclease uncovers a meiotic alteration in chromatin structure around the target site.
  4. the nonhomologous region of subunit A of the yeast V-ATPase is involved in coupling and in vivo dissociation
    Title: Involvement of the nonhomologous region of subunit A of the yeast V-ATPase in coupling and in vivo dissociation.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables DNA binding IEA
Inferred from Electronic Annotation
more info
  
enables endonuclease activity IEA
Inferred from Electronic Annotation
more info
  
enables mRNA binding HDA PubMed 
enables proton-transporting ATP synthase activity, rotational mechanism IEA
Inferred from Electronic Annotation
more info
  
enables proton-transporting ATPase activity, rotational mechanism IBA
Inferred from Biological aspect of Ancestor
more info
  
enables proton-transporting ATPase activity, rotational mechanism IDA
Inferred from Direct Assay
more info
 PubMed 
enables proton-transporting ATPase activity, rotational mechanism IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in ATP metabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in intein-mediated protein splicing IEA
Inferred from Electronic Annotation
more info
  
involved_in intron homing IEA
Inferred from Electronic Annotation
more info
  
involved_in protein metabolic process IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in proton motive force-driven ATP synthesis IEA
Inferred from Electronic Annotation
more info
  
involved_in proton transmembrane transport IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in proton transmembrane transport IEA
Inferred from Electronic Annotation
more info
  
involved_in vacuolar acidification IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in endomembrane system IEA
Inferred from Electronic Annotation
more info
  
located_in fungal-type vacuole membrane HDA PubMed 
is_active_in fungal-type vacuole membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in fungal-type vacuole membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
located_in vacuolar membrane IEA
Inferred from Electronic Annotation
more info
  
part_of vacuolar proton-transporting V-type ATPase, V1 domain IDA
Inferred from Direct Assay
more info
 PubMed 
located_in vacuole IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
H(+)-transporting V1 sector ATPase subunit A
NP_010096.1
  • Subunit A of the V1 peripheral membrane domain of V-ATPase; protein precursor undergoes self-catalyzed splicing to yield the extein Tfp1p and the intein Vde (PI-SceI), which is a site-specific endonuclease; the V1 peripheral membrane domain of the vacuolar H+-ATPase (V-ATPase) has eight subunits; involved in methionine restriction extension of chronological lifespan in an autophagy-dependent manner

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001136.10 Reference assembly

    Range
    126787..130002
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001180245.1 → NP_010096.1  TPA: H(+)-transporting V1 sector ATPase subunit A [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_010096.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6VRG7, O74301, P17255, Q9Y7W5
    UniProtKB/TrEMBL
    C8Z6B9, G2WBY0, N1P711
    Conserved Domains (2) summary
    TIGR01042
    Location:733 → 1063
    V-ATPase_V1_A; V-type (H+)-ATPase V1, A subunit
    pfam05203
    Location:284 → 736
    Hom_end_hint; Hom_end-associated Hint
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P17255.3

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