U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

PHO13 4-nitrophenylphosphatase [ Saccharomyces cerevisiae S288C ]

Gene ID: 851362, updated on 28-Oct-2024

Summary

Go to the top of the page Help
Official Symbol
PHO13
Official Full Name
4-nitrophenylphosphatase
Primary source
SGD:S000002395
Locus tag
YDL236W
See related
AllianceGenome:SGD:S000002395; FungiDB:YDL236W; VEuPathDB:YDL236W
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary
Enables alkaline phosphatase activity; phosphoglycolate phosphatase activity; and phosphoprotein phosphatase activity. Involved in carbohydrate metabolic process. Located in cytoplasm and nucleus. Orthologous to human PGP (phosphoglycolate phosphatase) and PDXP (pyridoxal phosphatase). [provided by Alliance of Genome Resources, Oct 2024]
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
See PHO13 in Genome Data Viewer
Location:
chromosome: IV
Exon count:
1
Sequence:
Chromosome: IV; NC_001136.10 (32296..33234)

Chromosome IV - NC_001136.10Genomic Context describing neighboring genes Neighboring gene guanine deaminase Neighboring gene Aim6p Neighboring gene Ypd1p Neighboring gene GTPase-activating protein GYP7

Genomic regions, transcripts, and products

Go to the top of the page Help
Genomic Sequence:
NC_001136.10

Go to nucleotide: Graphics FASTA GenBank

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. Molecular characterization of a specific p-nitrophenylphosphatase gene, PHO13, and its mapping by chromosome fragmentation in Saccharomyces cerevisiae. Kaneko Y, et al. Mol Gen Genet, 1989 Dec. PMID 2558283
  2. A conserved phosphatase destroys toxic glycolytic side products in mammals and yeast. Collard F, et al. Nat Chem Biol, 2016 Aug. PMID 27294321
  3. Deleting the para-nitrophenyl phosphatase (pNPPase), PHO13, in recombinant Saccharomyces cerevisiae improves growth and ethanol production on D-xylose. Van Vleet JH, et al. Metab Eng, 2008 Nov. PMID 18249574
  4. Deletion of the PHO13 gene in Saccharomyces cerevisiae improves ethanol production from lignocellulosic hydrolysate in the presence of acetic and formic acids, and furfural. Fujitomi K, et al. Bioresour Technol, 2012 May. PMID 22357292
  5. A specific alkaline phosphatase from Saccharomyces cerevisiae with protein phosphatase activity. Tuleva B, et al. FEMS Microbiol Lett, 1998 Apr 1. PMID 9561742

See all (53) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Phosphoglycolate phosphatase rescues central carbon metabolism from toxic secondary metabolites in humans and yeast.
    Title: A Guardian Angel Phosphatase for Mainline Carbon Metabolism.
  2. a conserved phosphatase (in yeast and mammals) destroys toxic glycolytic side products
    Title: A conserved phosphatase destroys toxic glycolytic side products in mammals and yeast.
  3. Transcriptome sequencing analysis revealed that pho13Delta resulted in upregulation of the pentose phosphate (PP) pathway and NADPH-producing enzymes when cells were grown on glucose or xylose.
    Title: Deletion of PHO13, encoding haloacid dehalogenase type IIA phosphatase, results in upregulation of the pentose phosphate pathway in Saccharomyces cerevisiae.
  4. findings demonstrate that PHO13 deletion is a simple, but effective, approach for improving cellulosic bioethanol production by S. cerevisiae
    Title: Deletion of the PHO13 gene in Saccharomyces cerevisiae improves ethanol production from lignocellulosic hydrolysate in the presence of acetic and formic acids, and furfural.
Submit: New GeneRIF Correction

Interactions

Go to the top of the page Help
Products Interactant Other Gene Complex Source Pubs Description

General gene information

Go to the top of the page Help

Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables alkaline phosphatase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables alkaline phosphatase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
  
enables phosphatase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables phosphatase activity IEA
Inferred from Electronic Annotation
more info
  
enables phosphoglycolate phosphatase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables phosphoglycolate phosphatase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables phosphoprotein phosphatase activity IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
involved_in carbohydrate metabolic process IDA
Inferred from Direct Assay
more info
 PubMed 
Component Evidence Code Pubs
located_in cytoplasm HDA PubMed 
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus HDA PubMed 

General protein information

Go to the top of the page Help
Preferred Names
4-nitrophenylphosphatase
NP_010045.1
  • Conserved phosphatase acting as a metabolite repair enzyme; shows specific dephosphorylating activity on two side-products of central carbohydrate metabolism, 2-phosphoglycolate and 4-phosphoerythronate; alkaline phosphatase specific for p-nitrophenyl phosphate; also has protein phosphatase activity; human ortholog PGP shows similar substrate specificity, deletion causes similar metabolite accumulation phenotypes, suggesting conserved role in eliminating glycolytic byproducts

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001136.10 Reference assembly

    Range
    32296..33234
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001180296.1 → NP_010045.1  TPA: 4-nitrophenylphosphatase [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_010045.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6VRC0, P19881, Q07689
    UniProtKB/TrEMBL
    A6ZX98, B3LHB2, B5VF45, C7GJQ5, N1PA86
    Conserved Domains (1) summary
    cd07510
    Location:24 → 308
    HAD_Pase_UmpH-like; UmpH/NagD family phosphatase, similar to human PGP phosphoglycolate phosphatase and Schizosaccharomyces pombe PHO2 p-nitrophenylphosphatase
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P19881.2

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Other Literature Sources
Molecular Biology Databases
Research Materials
Tools