DLD2 D-lactate dehydrogenase [Saccharomyces cerevisiae S288C] - Gene

Summary

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Official Symbol: DLD2
Official Full Name: D-lactate dehydrogenase
Primary source: SGD:S000002337
Locus tag: YDL178W
See related: AllianceGenome:SGD:S000002337; FungiDB:YDL178W; VEuPathDB:YDL178W
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Saccharomyces cerevisiae S288C (strain: S288C)
Lineage: Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Also known as: AIP2
Summary: Enables several functions, including (R)-2-hydroxyglutarate dehydrogenase activity; D-lactate dehydrogenase (cytochrome) activity; and FAD binding activity. Involved in lactate catabolic process. Located in mitochondrial matrix. Human ortholog(s) of this gene implicated in D-2-hydroxyglutaric aciduria 1. Orthologous to human D2HGDH (D-2-hydroxyglutarate dehydrogenase). [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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See DLD2 in Genome Data Viewer

Location:: chromosome: IV

Exon count:: 1

Sequence:: Chromosome: IV; NC_001136.10 (139522..141114)

Chromosome IV - NC_001136.10 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_001136.10

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

we conclude that the formation of a product-reduced Dld2 complex suppresses electron transfer to dioxygen but favors the rapid reduction in yETF, thus preventing the loss of electrons and the generation of reactive oxygen species.
Title: Closing the gap: yeast electron-transferring flavoprotein links the oxidation of d-lactate and d-α-hydroxyglutarate to energy production via the respiratory chain.
Dld2 and Dld3, both currently annotated as D-lactate dehydrogenases, efficiently oxidized d-2-hydroxyglutarate to alpha-ketoglutarate.
Title: Saccharomyces cerevisiae Forms D-2-Hydroxyglutarate and Couples Its Degradation to D-Lactate Formation via a Cytosolic Transhydrogenase.

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Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

Orthologs from OrthoDB

Gene Ontology Provided by SGD

Function	Evidence Code	Pubs
enables (R)-2-hydroxyglutarate dehydrogenase activity	IDA Inferred from Direct Assay more info	PubMed
enables D-lactate dehydrogenase (cytochrome) activity	IDA Inferred from Direct Assay more info	PubMed
enables D-lactate dehydrogenase (cytochrome) activity	IEA Inferred from Electronic Annotation more info
enables FAD binding	IDA Inferred from Direct Assay more info	PubMed
enables FAD binding	IEA Inferred from Electronic Annotation more info
enables actin binding	IMP Inferred from Mutant Phenotype more info	PubMed
enables catalytic activity	IEA Inferred from Electronic Annotation more info
enables oxidoreductase activity	IEA Inferred from Electronic Annotation more info
enables oxidoreductase activity, acting on CH-OH group of donors	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in lactate catabolic process	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in mitochondrial matrix	IDA Inferred from Direct Assay more info	PubMed
located_in mitochondrial matrix	IEA Inferred from Electronic Annotation more info
located_in mitochondrion	HDA more info	PubMed
is_active_in mitochondrion	IBA Inferred from Biological aspect of Ancestor more info
located_in mitochondrion	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: D-lactate dehydrogenase

NP_010103.1

EC 1.1.2.4

EC 1.1.99.40

D-2-hydroxyglutarate dehydrogenase, and minor D-lactate dehydrogenase; mitochondrial matrix protein that oxidizes D-2-hydroxyglutarate (D-2HG), an oncometabolite, to alpha-ketoglutarate with a minor role in lactate catabolism; located in the mitochondrial matrix

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_001136.10 Reference assembly

Range

139522..141114

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001180238.1 → NP_010103.1 TPA: D-lactate dehydrogenase [Saccharomyces cerevisiae S288C]

See identical proteins and their annotated locations for NP_010103.1

Status: REVIEWED

UniProtKB/Swiss-Prot

D6VRH4, P46681, Q66RH8

UniProtKB/TrEMBL

A6ZXF3, B3LH62, B5VF94, C7GL24, C8Z6C6, G2WBY7, N1PAJ9

Conserved Domains (1) summary

COG0277
Location:68 → 530

GlcD; FAD/FMN-containing dehydrogenase [Energy production and conversion]