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PCL2 [ Saccharomyces cerevisiae S288C ]

Gene ID: 851430, updated on 22-Aug-2024

Summary

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Official Symbol
PCL2
Primary source
FungiDB:YDL127W
Locus tag
YDL127W
See related
SGD:S000002285; AllianceGenome:SGD:S000002285; VEuPathDB:YDL127W
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Also known as
CLN4
Summary
Enables cyclin-dependent protein serine/threonine kinase regulator activity. Involved in regulation of cyclin-dependent protein serine/threonine kinase activity; regulation of establishment or maintenance of cell polarity; and septin ring organization. Located in cellular bud neck; cellular bud tip; and nucleus. Part of cyclin-dependent protein kinase holoenzyme complex and incipient cellular bud site. Orthologous to human CNPPD1 (cyclin Pas1/PHO80 domain containing 1). [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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Location:
chromosome: IV
Exon count:
1
Sequence:
Chromosome: IV; NC_001136.10 (234927..235853)

Chromosome IV - NC_001136.10Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene Vcx1p Neighboring gene AAA family ATPase CDC48 Neighboring gene adenosine 5'-monophosphoramidase

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001136.10

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. The PCL2 (ORFD)-PHO85 cyclin-dependent kinase complex: a cell cycle regulator in yeast. Measday V, et al. Science, 1994 Nov 25. PMID 7973731
  2. The GTPase-activating protein Rga1 interacts with Rho3 GTPase and may regulate its function in polarized growth in budding yeast. He F, et al. PLoS One, 2015. PMID 25860339, Free PMC Article
  3. Uncovering genetic relationships using small molecules that selectively target yeast cell cycle mutants. Nehil MT, et al. Chem Biol Drug Des, 2007 Apr. PMID 17461973
  4. Transcriptional coregulation by the cell integrity mitogen-activated protein kinase Slt2 and the cell cycle regulator Swi4. Baetz K, et al. Mol Cell Biol, 2001 Oct. PMID 11533240, Free PMC Article
  5. Interaction of yeast Rvs167 and Pho85 cyclin-dependent kinase complexes may link the cell cycle to the actin cytoskeleton. Lee J, et al. Curr Biol, 1998 Dec 3. PMID 9843683

See all (43) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables cyclin-dependent protein serine/threonine kinase regulator activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables cyclin-dependent protein serine/threonine kinase regulator activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables protein kinase binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in cell division IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of establishment or maintenance of cell polarity IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in regulation of establishment or maintenance of cell polarity IPI
Inferred from Physical Interaction
more info
 PubMed 
involved_in septin ring organization IGI
Inferred from Genetic Interaction
more info
 PubMed 
Component Evidence Code Pubs
located_in cellular bud neck IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cellular bud tip IDA
Inferred from Direct Assay
more info
 PubMed 
part_of cyclin-dependent protein kinase holoenzyme complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of cyclin-dependent protein kinase holoenzyme complex IEA
Inferred from Electronic Annotation
more info
  
part_of cyclin-dependent protein kinase holoenzyme complex IPI
Inferred from Physical Interaction
more info
 PubMed 
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in incipient cellular bud site IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
cyclin PCL2
NP_010156.2
  • Cyclin, interacts with cyclin-dependent kinase Pho85p; member of the Pcl1,2-like subfamily, involved in the regulation of polarized growth and morphogenesis and progression through the cell cycle; localizes to sites of polarized cell growth; PCL2 has a paralog, PCL9, that arose from the whole genome duplication

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001136.10 Reference assembly

    Range
    234927..235853
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001180186.1 → NP_010156.2  TPA: cyclin PCL2 [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_010156.2

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6VRM3, P25693, Q07554
    UniProtKB/TrEMBL
    A6ZXK2, B3LH17, B5VFE2, C7GJI9, C8Z6H6, G2WC35, N1P403
    Conserved Domains (1) summary
    cd20557
    Location:48 → 143
    CYCLIN_ScPCL1-like; cyclin box found in Saccharomyces cerevisiae G1/S-specific cyclin PCL1, PCL2 and similar proteins
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P25693.2

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