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QRI7 putative N(6)-L-threonylcarbamoyladenine synthase [ Saccharomyces cerevisiae S288C ]

Gene ID: 851454, updated on 3-Nov-2024

Summary

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Official Symbol
QRI7
Official Full Name
putative N(6)-L-threonylcarbamoyladenine synthase
Primary source
SGD:S000002262
Locus tag
YDL104C
See related
AllianceGenome:SGD:S000002262; FungiDB:YDL104C; VEuPathDB:YDL104C
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary
Enables N(6)-L-threonylcarbamoyladenine synthase activity; nucleotidase activity; and tRNA binding activity. Involved in mitochondrial tRNA threonylcarbamoyladenosine modification. Located in mitochondrion. Orthologous to human OSGEPL1 (O-sialoglycoprotein endopeptidase like 1). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See QRI7 in Genome Data Viewer
Location:
chromosome: IV
Exon count:
1
Sequence:
Chromosome: IV; NC_001136.10 (273653..274876, complement)

Chromosome IV - NC_001136.10Genomic Context describing neighboring genes Neighboring gene Pho2p Neighboring gene Smc5-Smc6 complex subunit NSE4 Neighboring gene UDP-N-acetylglucosamine diphosphorylase Neighboring gene DNA-directed DNA polymerase delta POL3

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001136.10

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Our results firmly established that Qri7p and Sua5p constitute the mitochondrial pathway for the biosynthesis of t(6)A and bring additional advancement in our understanding of the reaction mechanism
    Title: Cross kingdom functional conservation of the core universally conserved threonylcarbamoyladenosine tRNA synthesis enzymes.
  2. The manner of AMP recognition is similar, with some minor variations, among the Qri7/Kae1/YgjD family proteins
    Title: Structure of Saccharomyces cerevisiae mitochondrial Qri7 in complex with AMP.
  3. Qri7/OSGEPL protein localizes to the mitochondria and is involved in mitochondrial genome maintenance in the model eukaryotic organism, Saccharomyces cerevisiae.
    Title: Qri7/OSGEPL, the mitochondrial version of the universal Kae1/YgjD protein, is essential for mitochondrial genome maintenance.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables N(6)-L-threonylcarbamoyladenine synthase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables N(6)-L-threonylcarbamoyladenine synthase activity IEA
Inferred from Electronic Annotation
more info
  
enables acyltransferase activity IEA
Inferred from Electronic Annotation
more info
  
enables acyltransferase activity, transferring groups other than amino-acyl groups IEA
Inferred from Electronic Annotation
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables nucleotidase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables tRNA binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables zinc ion binding RCA
inferred from Reviewed Computational Analysis
more info
 PubMed 
Process Evidence Code Pubs
involved_in mitochondrial tRNA threonylcarbamoyladenosine modification IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in mitochondrial tRNA threonylcarbamoyladenosine modification IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in tRNA modification IEA
Inferred from Electronic Annotation
more info
  
involved_in tRNA processing IEA
Inferred from Electronic Annotation
more info
  
involved_in tRNA threonylcarbamoyladenosine metabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in tRNA threonylcarbamoyladenosine modification IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in tRNA threonylcarbamoyladenosine modification IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in mitochondrion HDA PubMed 
is_active_in mitochondrion IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in mitochondrion IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
putative N(6)-L-threonylcarbamoyladenine synthase
NP_010179.1
  • Protein involved in threonylcarbamoyl adenosine biosynthesis; Sua5p and Qri7p are necessary and sufficient for RNA t6A modification in vitro; highly conserved mitochondrial protein; essential for t6A modification of mitochondrial tRNAs that decode ANN codons; similar to Kae1p and E. coli YgjD, both of which are also required for tRNA t6A modification; when directed to the cytoplasm, complements the essential function of Kae1p in the KEOPS complex

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001136.10 Reference assembly

    Range
    273653..274876 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001180163.1 → NP_010179.1  TPA: putative N(6)-L-threonylcarbamoyladenine synthase [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_010179.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6VRP6, P43122
    UniProtKB/TrEMBL
    A6ZXM5, C8Z6K0
    Conserved Domains (1) summary
    TIGR00329
    Location:36 → 367
    gcp_kae1; metallohydrolase, glycoprotease/Kae1 family
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P43122.1

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