QRI1 UDP-N-acetylglucosamine diphosphorylase [Saccharomyces cerevisiae S288C] - Gene

Summary

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Official Symbol: QRI1
Official Full Name: UDP-N-acetylglucosamine diphosphorylase
Primary source: SGD:S000002261
Locus tag: YDL103C
See related: AllianceGenome:SGD:S000002261; FungiDB:YDL103C; VEuPathDB:YDL103C
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Saccharomyces cerevisiae S288C (strain: S288C)
Lineage: Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Also known as: UAP1
Summary: Enables UDP-N-acetylglucosamine diphosphorylase activity. Involved in UDP-N-acetylglucosamine biosynthetic process. Located in cytoplasm and nucleus. Orthologous to human UAP1 (UDP-N-acetylglucosamine pyrophosphorylase 1) and UAP1L1 (UDP-N-acetylglucosamine pyrophosphorylase 1 like 1). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See QRI1 in Genome Data Viewer

Location:: chromosome: IV

Exon count:: 1

Sequence:: Chromosome: IV; NC_001136.10 (275148..276581, complement)

Chromosome IV - NC_001136.10 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_001136.10

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

Orthologs from OrthoDB

Gene Ontology Provided by SGD

Function	Evidence Code	Pubs
enables UDP-N-acetylglucosamine diphosphorylase activity	IBA Inferred from Biological aspect of Ancestor more info
enables UDP-N-acetylglucosamine diphosphorylase activity	IDA Inferred from Direct Assay more info	PubMed
enables UDP-N-acetylglucosamine diphosphorylase activity	IEA Inferred from Electronic Annotation more info
enables nucleotidyltransferase activity	IEA Inferred from Electronic Annotation more info
enables transferase activity, transferring phosphorus-containing groups	IEA Inferred from Electronic Annotation more info
enables uridylyltransferase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in UDP-N-acetylglucosamine biosynthetic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in UDP-N-acetylglucosamine biosynthetic process	IDA Inferred from Direct Assay more info	PubMed
involved_in UDP-N-acetylglucosamine biosynthetic process	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in cytoplasm	HDA more info	PubMed
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in nucleus	HDA more info	PubMed

General protein information

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Preferred Names: UDP-N-acetylglucosamine diphosphorylase

NP_010180.1

EC 2.7.7.23

UDP-N-acetylglucosamine pyrophosphorylase; catalyzes the formation of UDP-N-acetylglucosamine (UDP-GlcNAc), which is important in cell wall biosynthesis, protein N-glycosylation, and GPI anchor biosynthesis; protein abundance increases in response to DNA replication stress

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_001136.10 Reference assembly

Range

275148..276581 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001180162.1 → NP_010180.1 TPA: UDP-N-acetylglucosamine diphosphorylase [Saccharomyces cerevisiae S288C]

See identical proteins and their annotated locations for NP_010180.1

Status: REVIEWED

UniProtKB/Swiss-Prot

D6VRP7, P43123

UniProtKB/TrEMBL

G2WC60

Conserved Domains (1) summary

COG4284
Location:1 → 477

QRI1; UDP-N-acetylglucosamine pyrophosphorylase [Carbohydrate transport and metabolism]