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SNU23 U4/U6-U5 snRNP complex subunit SNU23 [ Saccharomyces cerevisiae S288C ]

Gene ID: 851460, updated on 17-May-2024

Summary

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Gene symbol
SNU23
Gene description
U4/U6-U5 snRNP complex subunit SNU23
Primary source
FungiDB:YDL098C
Locus tag
YDL098C
See related
SGD:S000002256; AllianceGenome:SGD:S000002256; VEuPathDB:YDL098C
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary
Predicted to enable metal ion binding activity. Involved in mRNA splicing, via spliceosome. Part of U4/U6 x U5 tri-snRNP complex. Orthologous to human ZMAT2 (zinc finger matrin-type 2). [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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See SNU23 in Genome Data Viewer
Location:
chromosome: IV
Exon count:
1
Sequence:
Chromosome: IV; NC_001136.10 (284581..285165, complement)

Chromosome IV - NC_001136.10Genomic Context describing neighboring genes Neighboring gene guanine nucleotide exchange factor GET3 Neighboring gene Bug1p Neighboring gene proteasome regulatory particle lid subunit RPN6 Neighboring gene dolichyl-phosphate-mannose-protein mannosyltransferase PMT1

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001136.10

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. The EWS/NOR1 fusion gene product gains a novel activity affecting pre-mRNA splicing. Ohkura N, et al. J Biol Chem, 2002 Jan 4. PMID 11673470
  2. Human MFAP1 is a cryptic ortholog of the Saccharomyces cerevisiae Spp381 splicing factor. Ulrich AK, et al. BMC Evol Biol, 2017 Mar 24. PMID 28335716, Free PMC Article
  3. Structure of a pre-catalytic spliceosome. Plaschka C, et al. Nature, 2017 Jun 29. PMID 28530653, Free PMC Article
  4. Localization of Prp8, Brr2, Snu114 and U4/U6 proteins in the yeast tri-snRNP by electron microscopy. Häcker I, et al. Nat Struct Mol Biol, 2008 Nov. PMID 18953335
  5. Purification of the yeast U4/U6.U5 small nuclear ribonucleoprotein particle and identification of its proteins. Stevens SW, et al. Proc Natl Acad Sci U S A, 1999 Jun 22. PMID 10377396, Free PMC Article

See all (37) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables zinc ion binding RCA
inferred from Reviewed Computational Analysis
more info
 PubMed 
Process Evidence Code Pubs
involved_in RNA splicing IEA
Inferred from Electronic Annotation
more info
  
involved_in mRNA processing IEA
Inferred from Electronic Annotation
more info
  
involved_in mRNA splicing, via spliceosome IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in mRNA splicing, via spliceosome IEA
Inferred from Electronic Annotation
more info
  
involved_in mRNA splicing, via spliceosome IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
part_of U4/U6 x U5 tri-snRNP complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of U4/U6 x U5 tri-snRNP complex IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  
part_of spliceosomal complex IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
U4/U6-U5 snRNP complex subunit SNU23
NP_010185.1
  • Component of the U4/U6.U5 snRNP complex; involved in mRNA splicing via spliceosome

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001136.10 Reference assembly

    Range
    284581..285165 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001180157.1 → NP_010185.1  TPA: U4/U6-U5 snRNP complex subunit SNU23 [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_010185.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6VRQ2, Q12368
    UniProtKB/TrEMBL
    A0A6A5Q1K2, A6ZXN1, B3LGZ1, C7GJL8, C8Z6K6, G2WC66, N1PA94
    Conserved Domains (1) summary
    pfam12874
    Location:80 → 104
    zf-met; Zinc-finger of C2H2 type
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
5ZWO_W.1
Q12368.1

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