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STP4 Stp4p [ Saccharomyces cerevisiae S288C ]

Gene ID: 851512, updated on 2-Nov-2024

Summary

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Official Symbol
STP4
Official Full Name
Stp4p
Primary source
SGD:S000002206
Locus tag
YDL048C
See related
AllianceGenome:SGD:S000002206; FungiDB:YDL048C; VEuPathDB:YDL048C
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary
Enables sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Located in mitochondrion and nucleus. [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See STP4 in Genome Data Viewer
Location:
chromosome: IV
Exon count:
1
Sequence:
Chromosome: IV; NC_001136.10 (366739..368211, complement)

Chromosome IV - NC_001136.10Genomic Context describing neighboring genes Neighboring gene Lhp1p Neighboring gene Knh1p Neighboring gene type 2A-related serine/threonine-protein phosphatase SIT4 Neighboring gene sterol transporter

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001136.10

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Combining Deep Sequencing, Proteomics, Phosphoproteomics, and Functional Screens To Discover Novel Regulators of Sphingolipid Homeostasis. Lebesgue N, et al. J Proteome Res, 2017 Feb 3. PMID 28152593
  2. Identifying cooperative transcription factors by combining ChIP-chip data and knockout data. Yang Y, et al. Cell Res, 2010 Nov. PMID 20975739
  3. The external amino acid signaling pathway promotes activation of Stp1 and Uga35/Dal81 transcription factors for induction of the AGP1 gene in Saccharomyces cerevisiae. Abdel-Sater F, et al. Genetics, 2004 Apr. PMID 15126393, Free PMC Article
  4. Sex alters molecular evolution in diploid experimental populations of S. cerevisiae. Leu JY, et al. Nat Ecol Evol, 2020 Mar. PMID 32042122
  5. Analysis of unregulated formin activity reveals how yeast can balance F-actin assembly between different microfilament-based organizations. Gao L, et al. Mol Biol Cell, 2008 Apr. PMID 18234843, Free PMC Article

See all (35) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Atg9, Stp4, and Gvp36 are putative new regulators of sphingolipid homeostasis in Saccharomyces cerevisiae.
    Title: Combining Deep Sequencing, Proteomics, Phosphoproteomics, and Functional Screens To Discover Novel Regulators of Sphingolipid Homeostasis.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
Inferred from Biological aspect of Ancestor
more info
  
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables sequence-specific DNA binding HDA PubMed 
enables zinc ion binding RCA
inferred from Reviewed Computational Analysis
more info
 PubMed 
Process Evidence Code Pubs
involved_in biological_process ND
No biological Data available
more info
  
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in cytoplasm HDA PubMed 
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in mitochondrion HDA PubMed 
located_in mitochondrion IEA
Inferred from Electronic Annotation
more info
  
located_in nucleus HDA PubMed 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
Stp4p
NP_010235.1
  • Protein containing a Kruppel-type zinc-finger domain; similar to Stp1p, Stp2p; predicted transcription factor; relative distribution to the nucleus increases upon DNA replication stress; STP4 has a paralog, STP3, that arose from the whole genome duplication

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001136.10 Reference assembly

    Range
    366739..368211 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001180107.1 → NP_010235.1  TPA: Stp4p [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_010235.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6VRU7, P87336, Q05422, Q07351, Q7LGT2, Q7LH06
    UniProtKB/TrEMBL
    A6ZXS6, G2WCB2
    Conserved Domains (2) summary
    COG5048
    Location:14 → 442
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:279 → 296
    ZF_C2H2; C2H2 Zn finger [structural motif]
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q07351.2

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