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NPC2 sterol transporter [ Saccharomyces cerevisiae S288C ]

Gene ID: 851514, updated on 4-Nov-2024

Summary

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Official Symbol
NPC2
Official Full Name
sterol transporter
Primary source
SGD:S000002204
Locus tag
YDL046W
See related
AllianceGenome:SGD:S000002204; FungiDB:YDL046W; VEuPathDB:YDL046W
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary
Enables phospholipid binding activity and sterol binding activity. Involved in intracellular sterol transport. Located in fungal-type vacuole lumen. Used to study Niemann-Pick disease and Niemann-Pick disease type C2. [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See NPC2 in Genome Data Viewer
Location:
chromosome: IV
Exon count:
1
Sequence:
Chromosome: IV; NC_001136.10 (371240..371761)

Chromosome IV - NC_001136.10Genomic Context describing neighboring genes Neighboring gene Stp4p Neighboring gene type 2A-related serine/threonine-protein phosphatase SIT4 Neighboring gene mitochondrial 37S ribosomal protein YmS-T Neighboring gene FMN adenylyltransferase

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001136.10

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Saccharomyces cerevisiae Npc2p is a functionally conserved homologue of the human Niemann-Pick disease type C 2 protein, hNPC2. Berger AC, et al. Eukaryot Cell, 2005 Nov. PMID 16278452, Free PMC Article
  2. Mechanistic Insight into Lipid Binding to Yeast Niemann Pick Type C2 Protein. Moesgaard L, et al. Biochemistry, 2020 Nov 17. PMID 33141558
  3. Structural and biochemical analysis of ligand binding in yeast Niemann-Pick type C1-related protein. Nel L, et al. Life Sci Alliance, 2025 Jan. PMID 39455279, Free PMC Article
  4. Niemann-Pick type C proteins promote microautophagy by expanding raft-like membrane domains in the yeast vacuole. Tsuji T, et al. Elife, 2017 Jun 7. PMID 28590904, Free PMC Article
  5. Structural Insight into Eukaryotic Sterol Transport through Niemann-Pick Type C Proteins. Winkler MBL, et al. Cell, 2019 Oct 3. PMID 31543266

See all (30) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Structural and biochemical analysis of ligand binding in yeast Niemann-Pick type C1-related protein.
    Title: Structural and biochemical analysis of ligand binding in yeast Niemann-Pick type C1-related protein.
  2. Mechanistic Insight into Lipid Binding to Yeast Niemann Pick Type C2 Protein.
    Title: Mechanistic Insight into Lipid Binding to Yeast Niemann Pick Type C2 Protein.
  3. this study presents four structures of yeast NCR1 and NPC2.
    Title: Structural Insight into Eukaryotic Sterol Transport through Niemann-Pick Type C Proteins.
  4. These data show that Ncr1p and Npc2p proteins promote microautophagy in stationary phase and under nitrogen starvation conditions, likely by increasing sterol in the limiting membrane of the vacuole.
    Title: Niemann-Pick type C proteins promote microautophagy by expanding raft-like membrane domains in the yeast vacuole.
  5. Data show that Npc2p is evolutionarily related to the mammalian NPC2 family of proteins, and is treated similarly to human NPC2 when expressed in mammalian cells.
    Title: Saccharomyces cerevisiae Npc2p is a functionally conserved homologue of the human Niemann-Pick disease type C 2 protein, hNPC2.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables phosphatidylcholine binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables phosphatidylinositol binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables phosphatidylserine binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables sterol binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables sterol binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables sterol binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in intracellular sterol transport IEA
Inferred from Electronic Annotation
more info
  
involved_in intracellular sterol transport IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in lipid transport IEA
Inferred from Electronic Annotation
more info
  
involved_in sterol transport IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in sterol transport IDA
Inferred from Direct Assay
more info
 PubMed 
Component Evidence Code Pubs
located_in fungal-type vacuole HDA PubMed 
located_in fungal-type vacuole lumen IDA
Inferred from Direct Assay
more info
 PubMed 
located_in vacuole IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
sterol transporter
NP_010237.1
  • Sterol transport protein, functional homolog of human NPC2 Niemann-Pick disease type C2 protein; together with Ncr1p mediates integration of ergosterol into vacuolar membrane; functions as general 'lipid solubilizer', binds variety of amphiphilic lipid ligands; targeted to vacuole via Vps10p-dependent endosomal vacuolar protein sorting pathway; yeast NPC2 can complement mutations in human NPC2

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001136.10 Reference assembly

    Range
    371240..371761
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001180105.1 → NP_010237.1  TPA: sterol transporter [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_010237.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6VRU9, Q12408
    UniProtKB/TrEMBL
    A6ZXS8, G2WCB4, N1P5V1
    Conserved Domains (1) summary
    cd00917
    Location:44 → 168
    PG-PI_TP; The phosphatidylinositol/phosphatidylglycerol transfer protein (PG/PI-TP) has been shown to bind phosphatidylglycerol and phosphatidylinositol, but the biological significance of this is still obscure. These proteins belong to the ML domain family.
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q12408.1

Gene LinkOut

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