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RPN4 stress-regulated transcription factor RPN4 [ Saccharomyces cerevisiae S288C ]

Gene ID: 851542, updated on 2-Nov-2024

Summary

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Official Symbol
RPN4
Official Full Name
stress-regulated transcription factor RPN4
Primary source
SGD:S000002178
Locus tag
YDL020C
See related
AllianceGenome:SGD:S000002178; FungiDB:YDL020C; VEuPathDB:YDL020C
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Also known as
SON1; UFD5
Summary
Enables DNA-binding transcription activator activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Involved in cellular response to arsenic-containing substance; regulation of DNA repair; and regulation of transcription by RNA polymerase II. Located in nucleus. [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See RPN4 in Genome Data Viewer
Location:
chromosome: IV
Exon count:
1
Sequence:
Chromosome: IV; NC_001136.10 (415113..416708, complement)

Chromosome IV - NC_001136.10Genomic Context describing neighboring genes Neighboring gene glycerol-3-phosphate dehydrogenase (NAD(+)) GPD1 Neighboring gene phosphoglycerate mutase family protein GPM2 Neighboring gene oxysterol-binding protein related protein OSH2 Neighboring gene Erp3p

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001136.10

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. [Escherichia coli Dam methylase as a molecular tool for mapping binding sites of the yeast transcription factor Rpn4]. Spasskaia DS, et al. Mol Biol (Mosk), 2011 Jul-Aug. PMID 21954596
  2. Proteasomal degradation of RPN4 via two distinct mechanisms, ubiquitin-dependent and -independent. Ju D, et al. J Biol Chem, 2004 Jun 4. PMID 15090546
  3. [Rpn4p is a positive and negative transcriptional regulator of the ubiquitin-proteasome system]. Karpov DS, et al. Mol Biol (Mosk), 2008 May-Jun. PMID 18702311
  4. [Mapping of Rpn4p regions responsible for transcriptional activation of proteasome genes]. Karpov DS, et al. Mol Biol (Mosk), 2008 May-Jun. PMID 18702312
  5. Mapping of yeast Rpn4p transactivation domains. Karpov DS, et al. FEBS Lett, 2008 Oct 15. PMID 18804109

See all (210) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Impairment of RPN4, a transcription factor, induces ER stress and lipid abnormality in Saccharomyces cerevisiae.
    Title: Impairment of RPN4, a transcription factor, induces ER stress and lipid abnormality in Saccharomyces cerevisiae.
  2. [Rpn4p without the DNA-Binding Domain Provides Saccharomyces cerevisiae Resistance to Oxidative Stress and Cycloheximide].
    Title: [Rpn4p without the DNA-Binding Domain Provides Saccharomyces cerevisiae Resistance to Oxidative Stress and Cycloheximide].
  3. The authors identify the proteasome biogenesis regulator Rpn4 and show that it cooperates with the unfolded protein response. Rpn4 abundance increases during endoplasmic reticulum stress, first by a post-transcriptional, then by a transcriptional mechanism.
    Title: The proteasome biogenesis regulator Rpn4 cooperates with the unfolded protein response to promote ER stress resistance.
  4. Rpn4 induces TMC1 transcription in response to misfolded proteins. However, this response is counteracted by rapid proteasome-dependent degradation of Tmc1, which serves to normalize Tmc1 protein levels after induction
    Title: Tmc1 Is a Dynamically Regulated Effector of the Rpn4 Proteotoxic Stress Response.
  5. Rpn4-responsive elements in genes related to proteasome functions
    Title: Identification of minimum Rpn4-responsive elements in genes related to proteasome functions.
  6. under the methyl methanesulfonate stress Rpn4 promotes the regulation of several genes involved in DNA repair, antioxidant response and glucose metabolism.
    Title: [RPN4 the yeast transcription factor promotes the complex defence against methyi, methanesulfonate].
  7. the ubiquitin-independent degradation of Rpn4 requires the 19S regulatory particle.
    Title: The N-terminal domain of Rpn4 serves as a portable ubiquitin-independent degron and is recognized by specific 19S RP subunits.
  8. evidence for the role of proteasomal degradation of Rpn4 in nonhomologous end-joining
    Title: Inhibition of proteasomal degradation of rpn4 impairs nonhomologous end-joining repair of DNA double-strand breaks.
  9. Intracellular proteasome activity is correlated with the transactivation potency of Rpn4.
    Title: The transcription activation domain of Rpn4 is separate from its degrons.
  10. Rpn4 thus represents an important stress-responsive mediator whose degradation as well as availability are critical for cell survival under stressed conditions.
    Title: Proteasomal degradation of Rpn4 in Saccharomyces cerevisiae is critical for cell viability under stressed conditions.
Submit: New GeneRIF Correction See all GeneRIFs (21)

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables DNA binding IEA
Inferred from Electronic Annotation
more info
  
enables DNA-binding transcription activator activity, RNA polymerase II-specific IDA
Inferred from Direct Assay
more info
 PubMed 
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
involved_in cellular response to arsenic-containing substance HMP PubMed 
involved_in cellular response to arsenic-containing substance IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in cellular response to stress HMP PubMed 
involved_in cellular response to stress IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in negative regulation of transcription by RNA polymerase II HMP PubMed 
involved_in negative regulation of transcription by RNA polymerase II IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of transcription by RNA polymerase II HMP PubMed 
involved_in positive regulation of transcription by RNA polymerase II IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in positive regulation of transcription by RNA polymerase II IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in positive regulation of transcription by RNA polymerase II IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of DNA repair IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in cytoplasm HDA PubMed 
located_in nucleus HDA PubMed 
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
stress-regulated transcription factor RPN4
NP_010264.3
  • Transcription factor that stimulates expression of proteasome genes; Rpn4p levels are in turn regulated by the 26S proteasome in a negative feedback control mechanism; RPN4 is transcriptionally regulated by various stress responses; relative distribution to the nucleus increases upon DNA replication stress

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001136.10 Reference assembly

    Range
    415113..416708 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001180079.3 → NP_010264.3  TPA: stress-regulated transcription factor RPN4 [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_010264.3

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6VRX0, E9P944, Q03465
    UniProtKB/TrEMBL
    C7GW59, C8Z4P9, N1P5X6
    Conserved Domains (1) summary
    sd00017
    Location:450 → 468
    ZF_C2H2; C2H2 Zn finger [structural motif]
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q03465.1

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