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MED2 Med2p [ Saccharomyces cerevisiae S288C ]

Gene ID: 851559, updated on 2-Nov-2024

Summary

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Official Symbol
MED2
Official Full Name
Med2p
Primary source
SGD:S000002163
Locus tag
YDL005C
See related
AllianceGenome:SGD:S000002163; FungiDB:YDL005C; VEuPathDB:YDL005C
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary
Enables RNA polymerase II-specific DNA-binding transcription factor binding activity and transcription coactivator activity. Involved in RNA polymerase II preinitiation complex assembly; negative regulation of transcription by RNA polymerase II; and positive regulation of transcription by RNA polymerase II. Acts upstream of or within replicative senescence and response to endoplasmic reticulum stress. Located in cytosol and nucleus. Part of core mediator complex and mediator complex. [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See MED2 in Genome Data Viewer
Location:
chromosome: IV
Exon count:
1
Sequence:
Chromosome: IV; NC_001136.10 (441014..442309, complement)

Chromosome IV - NC_001136.10Genomic Context describing neighboring genes Neighboring gene proteasome regulatory particle base subunit RPT2 Neighboring gene type 2C protein phosphatase PTC1 Neighboring gene F1F0 ATP synthase subunit delta Neighboring gene kleisin alpha

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001136.10

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Proteolytic instability and the action of nonclassical transcriptional activators. Wang X, et al. Curr Biol, 2010 May 11. PMID 20417106, Free PMC Article
  2. A triad of subunits from the Gal11/tail domain of Srb mediator is an in vivo target of transcriptional activator Gcn4p. Zhang F, et al. Mol Cell Biol, 2004 Aug. PMID 15254252, Free PMC Article
  3. Mediator, SWI/SNF and SAGA complexes regulate Yap8-dependent transcriptional activation of ACR2 in response to arsenate. Menezes RA, et al. Biochim Biophys Acta Gene Regul Mech, 2017 Apr. PMID 28188921
  4. Site-specific Srb10-dependent phosphorylation of the yeast Mediator subunit Med2 regulates gene expression from the 2-microm plasmid. Hallberg M, et al. Proc Natl Acad Sci U S A, 2004 Mar 9. PMID 14988503, Free PMC Article
  5. Mediator protein mutations that selectively abolish activated transcription. Myers LC, et al. Proc Natl Acad Sci U S A, 1999 Jan 5. PMID 9874773, Free PMC Article

See all (98) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables RNA polymerase II-specific DNA-binding transcription factor binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables transcription coactivator activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Process Evidence Code Pubs
involved_in RNA polymerase II preinitiation complex assembly IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in negative regulation of transcription by RNA polymerase II IPI
Inferred from Physical Interaction
more info
 PubMed 
involved_in positive regulation of transcription by RNA polymerase II IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_or_within replicative senescence IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within response to endoplasmic reticulum stress IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
part_of core mediator complex IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cytosol IDA
Inferred from Direct Assay
more info
 PubMed 
part_of mediator complex IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
Med2p
NP_010279.3
  • Subunit of the RNA polymerase II mediator complex; associates with core polymerase subunits to form the RNA polymerase II holoenzyme; essential for transcriptional regulation; relocalizes to the cytosol in response to hypoxia

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001136.10 Reference assembly

    Range
    441014..442309 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001180064.3 → NP_010279.3  TPA: Med2p [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_010279.3

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6VRY3, Q12124
    UniProtKB/TrEMBL
    A6ZXW1, B3LGR3, N1P693
    Conserved Domains (1) summary
    pfam11214
    Location:27 → 141
    Med2; Mediator complex subunit 2
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q12124.1

Gene LinkOut

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