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RAD28 Rad28p [ Saccharomyces cerevisiae S288C ]

Gene ID: 851594, updated on 2-Nov-2024

Summary

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Official Symbol
RAD28
Official Full Name
Rad28p
Primary source
SGD:S000002437
Locus tag
YDR030C
See related
AllianceGenome:SGD:S000002437; FungiDB:YDR030C; VEuPathDB:YDR030C
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary
Involved in DNA repair. Predicted to be located in nucleus. Predicted to be part of Cul4A-RING E3 ubiquitin ligase complex and nucleotide-excision repair complex. Human ortholog(s) of this gene implicated in Cockayne syndrome; Cockayne syndrome A; and UV-sensitive syndrome. Orthologous to human ERCC8 (ERCC excision repair 8, CSA ubiquitin ligase complex subunit). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See RAD28 in Genome Data Viewer
Location:
chromosome: IV
Exon count:
1
Sequence:
Chromosome: IV; NC_001136.10 (501753..503273, complement)

Chromosome IV - NC_001136.10Genomic Context describing neighboring genes Neighboring gene protein phosphatase regulator REG1 Neighboring gene uncharacterized protein Neighboring gene Mix14p Neighboring gene flavodoxin-like fold family protein

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001136.10

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Molecular cloning and characterization of Saccharomyces cerevisiae RAD28, the yeast homolog of the human Cockayne syndrome A (CSA) gene. Bhatia PK, et al. J Bacteriol, 1996 Oct. PMID 8830695, Free PMC Article
  2. Functional analysis of six ORFs from Saccharomyces cerevisiae chromosome IV: two-spored asci produced by disruptant of YDR027c and strain-dependent DNA heterogeneity around YDR036c. Aittamaa M, et al. Yeast, 2001 Jul. PMID 11447599
  3. A compromised yeast RNA polymerase II enhances UV sensitivity in the absence of global genome nucleotide excision repair. Wong JM, et al. Mol Gen Genet, 2001 Feb. PMID 11254132
  4. NuA3 HAT antagonizes the Rpd3S and Rpd3L HDACs to optimize mRNA and lncRNA expression dynamics. Kim JH, et al. Nucleic Acids Res, 2020 Nov 4. PMID 33010166, Free PMC Article
  5. Functional dissection of protein complexes involved in yeast chromosome biology using a genetic interaction map. Collins SR, et al. Nature, 2007 Apr 12. PMID 17314980

See all (16) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables molecular_function ND
No biological Data available
more info
  
Process Evidence Code Pubs
involved_in DNA repair IEA
Inferred from Electronic Annotation
more info
  
involved_in DNA repair IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in proteasome-mediated ubiquitin-dependent protein catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in protein polyubiquitination IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in transcription-coupled nucleotide-excision repair IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in transcription-coupled nucleotide-excision repair IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
part_of Cul4A-RING E3 ubiquitin ligase complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of nucleotide-excision repair complex IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus IC
Inferred by Curator
more info
 PubMed 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
Rad28p
NP_010313.3
  • Protein involved in DNA repair; related to the human CSA protein that is involved in transcription-coupled repair nucleotide excision repair

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001136.10 Reference assembly

    Range
    501753..503273 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001180338.3 → NP_010313.3  TPA: Rad28p [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_010313.3

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6VS14, Q12021
    UniProtKB/TrEMBL
    B3LGN6, C8Z4V0, N1P805
    Conserved Domains (2) summary
    COG2319
    Location:1 → 386
    WD40; WD40 repeat [General function prediction only]
    sd00039
    Location:198 → 233
    7WD40; WD40 repeat [structural motif]
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q12021.1

Gene LinkOut

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