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KRS1 lysine--tRNA ligase KRS1 [ Saccharomyces cerevisiae S288C ]

Gene ID: 851607, updated on 2-Nov-2024

Summary

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Official Symbol
KRS1
Official Full Name
lysine--tRNA ligase KRS1
Primary source
SGD:S000002444
Locus tag
YDR037W
See related
AllianceGenome:SGD:S000002444; FungiDB:YDR037W; VEuPathDB:YDR037W
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Also known as
GCD5
Summary
Enables lysine-tRNA ligase activity and sequence-specific mRNA binding activity. Involved in lysyl-tRNA aminoacylation. Located in cytoplasm. Used to study Charcot-Marie-Tooth disease recessive intermediate B; autosomal recessive nonsyndromic deafness 89; hypomyelinating leukoencephalopathy; and ophthalmoplegia. Human ortholog(s) of this gene implicated in Charcot-Marie-Tooth disease recessive intermediate B and autosomal recessive nonsyndromic deafness 89. Orthologous to human KARS1 (lysyl-tRNA synthetase 1). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See KRS1 in Genome Data Viewer
Location:
chromosome: IV
Exon count:
1
Sequence:
Chromosome: IV; NC_001136.10 (525440..527215)

Chromosome IV - NC_001136.10Genomic Context describing neighboring genes Neighboring gene 3-deoxy-7-phosphoheptulonate synthase ARO3 Neighboring gene mitochondrial 37S ribosomal protein EHD3 Neighboring gene putative Na(+)-exporting P-type ATPase ENA5 Neighboring gene Na(+)-exporting P-type ATPase ENA2

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001136.10

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Do yeast aminoacyl-tRNA synthetases exist as soluble enzymes within the cytoplasm? Cirakoglu B, et al. Eur J Biochem, 1985 Jun 3. PMID 3888626
  2. Selective and specific inhibition of the plasmodium falciparum lysyl-tRNA synthetase by the fungal secondary metabolite cladosporin. Hoepfner D, et al. Cell Host Microbe, 2012 Jun 14. PMID 22704625, Free PMC Article
  3. Loss-of-function mutations in Lysyl-tRNA synthetase cause various leukoencephalopathy phenotypes. Sun C, et al. Neurol Genet, 2019 Apr. PMID 31192300, Free PMC Article
  4. The yeast lysyl-tRNA synthetase gene. Evidence for general amino acid control of its expression and domain structure of the encoded protein. Mirande M, et al. J Biol Chem, 1988 Dec 5. PMID 2903861
  5. The polyanion-binding domain of cytoplasmic Lys-tRNA synthetase from Saccharomyces cerevisiae is not essential for cell viability. Martinez R, et al. Eur J Biochem, 1992 Jul 1. PMID 1628641

See all (73) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables aminoacyl-tRNA ligase activity IEA
Inferred from Electronic Annotation
more info
  
enables lysine-tRNA ligase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables lysine-tRNA ligase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables lysine-tRNA ligase activity IEA
Inferred from Electronic Annotation
more info
  
enables lysine-tRNA ligase activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables mRNA binding HDA PubMed 
enables nucleic acid binding IEA
Inferred from Electronic Annotation
more info
  
enables sequence-specific mRNA binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables tRNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in lysyl-tRNA aminoacylation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in lysyl-tRNA aminoacylation IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in lysyl-tRNA aminoacylation IEA
Inferred from Electronic Annotation
more info
  
involved_in lysyl-tRNA aminoacylation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in tRNA aminoacylation for protein translation IEA
Inferred from Electronic Annotation
more info
  
involved_in translation IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
lysine--tRNA ligase KRS1
NP_010322.1
  • Lysyl-tRNA synthetase

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001136.10 Reference assembly

    Range
    525440..527215
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001180345.1 → NP_010322.1  TPA: lysine--tRNA ligase KRS1 [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_010322.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6VS25, P15180
    UniProtKB/TrEMBL
    A6ZY05, B3LGM8, B5VFU1, C8Z4V9
    Conserved Domains (1) summary
    PLN02502
    Location:24 → 579
    PLN02502; lysyl-tRNA synthetase
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P15180.2

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