VMS1 Vms1p [Saccharomyces cerevisiae S288C] - Gene

Summary

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Official Symbol: VMS1
Official Full Name: Vms1p
Primary source: SGD:S000002456
Locus tag: YDR049W
See related: AllianceGenome:SGD:S000002456; FungiDB:YDR049W; VEuPathDB:YDR049W
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Saccharomyces cerevisiae S288C (strain: S288C)
Lineage: Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary: Enables aminoacyl-tRNA hydrolase activity. Contributes to thiol-dependent deubiquitinase. Involved in mitochondria-associated ubiquitin-dependent protein catabolic process; nuclear protein quality control by the ubiquitin-proteasome system; and ubiquitin-dependent ERAD pathway. Located in cytosol; endoplasmic reticulum membrane; and mitochondrion. Part of Cdc48p-Npl4p-Vms1p AAA ATPase complex. Colocalizes with ribosome. Used to study inflammatory bowel disease. Orthologous to human ANKZF1 (ankyrin repeat and zinc finger peptidyl tRNA hydrolase 1). [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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See VMS1 in Genome Data Viewer

Location:: chromosome: IV

Exon count:: 1

Sequence:: Chromosome: IV; NC_001136.10 (553254..555152)

Chromosome IV - NC_001136.10 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_001136.10

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Stress Responses Elicited by Misfolded Proteins Targeted to Mitochondria.
Title: Stress Responses Elicited by Misfolded Proteins Targeted to Mitochondria.
ER-misfolded proteins become sequestered with mitochondria and impair mitochondrial function.
Title: ER-misfolded proteins become sequestered with mitochondria and impair mitochondrial function.
structure and function of Vms1 and Arb1 in ribosome-associated quality control (RQC) and mitochondrial proteome homeostasis
Title: Structure and function of Vms1 and Arb1 in RQC and mitochondrial proteome homeostasis.
Data indicate Vms1p as a tRNA hydrolase that releases stalled polypeptides engaged by the ribosome-associated quality control complex (RQC).
Title: Vms1p is a release factor for the ribosome-associated quality control complex.
Cdc48 adaptor Vms1 is a peptidyl-tRNA hydrolase; similar to classical eukaryotic release factor 1, Vms1 activity is dependent on a conserved catalytic glutamine; evolutionary analysis indicates that yeast Vms1 is the founding member of a clade of eukaryotic release factor 1 homologues that are designated the Vms1-like release factor 1 clade
Title: Vms1 and ANKZF1 peptidyl-tRNA hydrolases release nascent chains from stalled ribosomes.
Vms1 binds to 60S ribosomes at the mitochondrial surface and antagonizes Rqc2, thereby facilitating import, impeding aggregation, and directing aberrant polypeptides to intra-mitochondrial quality control.
Title: Cytosolic Protein Vms1 Links Ribosome Quality Control to Mitochondrial and Cellular Homeostasis.
Vms1 is preferentially recruited to mitochondria subjected to oxidative stress.
Title: Intramolecular interactions control Vms1 translocation to damaged mitochondria.
The results suggest that Cdc48p controls mitochondrial morphology by regulating turnover of proteins involved in mitochondrial morphology in a Vms1p-independent manner.
Title: Cdc48p/p97-mediated regulation of mitochondrial morphology is Vms1p-independent.
show that both Cdc48 and Vms1, but not Cdc48 cofactors Ufd1 and Ufd2, are crucial for the degradation of Cdc13, a telomere regulator
Title: The Cdc48 protein and its cofactor Vms1 are involved in Cdc13 protein degradation.
the p97/valosin-containing protein (VCP)-interacting motif (VIM) delineates a new family of p97 cofactors
Title: The general definition of the p97/valosin-containing protein (VCP)-interacting motif (VIM) delineates a new family of p97 cofactors.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

px-6e8 (e-PCR)
- UniSTS:258142

Homology

Orthologs from OrthoDB

Gene Ontology Provided by SGD

Function	Evidence Code	Pubs
enables RNA endonuclease activity	IDA Inferred from Direct Assay more info	PubMed
enables aminoacyl-tRNA hydrolase activity	IDA Inferred from Direct Assay more info	PubMed
enables endonuclease activity	IEA Inferred from Electronic Annotation more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables zinc ion binding	RCA inferred from Reviewed Computational Analysis more info	PubMed

Process	Evidence Code	Pubs
involved_in ERAD pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in ERAD pathway	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in mitochondria-associated ubiquitin-dependent protein catabolic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in nuclear protein quality control by the ubiquitin-proteasome system	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in rescue of stalled ribosome	IDA Inferred from Direct Assay more info	PubMed

Component	Evidence Code	Pubs
part_of Cdc48p-Npl4p-Vms1p AAA ATPase complex	IDA Inferred from Direct Assay more info	PubMed
located_in cytoplasm	HDA more info	PubMed
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in cytosol	IDA Inferred from Direct Assay more info	PubMed
located_in endoplasmic reticulum	IEA Inferred from Electronic Annotation more info
located_in endoplasmic reticulum membrane	IDA Inferred from Direct Assay more info	PubMed
located_in endoplasmic reticulum membrane	IEA Inferred from Electronic Annotation more info
located_in membrane	IEA Inferred from Electronic Annotation more info
located_in mitochondrion	HDA more info	PubMed
located_in mitochondrion	IDA Inferred from Direct Assay more info	PubMed
located_in mitochondrion	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: Vms1p

NP_010334.1

Peptidyl-tRNA hydrolase that releases stalled peptides from ribosomes, component of a Cdc48p-complex; involved in protein quality control; exhibits cytosolic and ER-membrane localization; contributes to ER-associated degradation (ERAD) of specific substrates at a step after their ubiquitination; translocates to mitochondria under oxidative stress and forms a complex with Cdc48p and Npl4p that is required for ubiquitin-mediated mitochondria-associated protein degradation (MAD)

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_001136.10 Reference assembly

Range

553254..555152

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001180357.1 → NP_010334.1 TPA: Vms1p [Saccharomyces cerevisiae S288C]

See identical proteins and their annotated locations for NP_010334.1

Status: REVIEWED

UniProtKB/Swiss-Prot

D6VS36, Q04311, Q66RH0

UniProtKB/TrEMBL

C7GTA1

Conserved Domains (3) summary

PTZ00448
Location:22 → 115

PTZ00448; hypothetical protein; Provisional

sd00020
Location:74 → 96

ZF_C2H2; C2H2 Zn finger [structural motif]

pfam18826
Location:237 → 397

bVLRF1; bacteroidetes VLRF1 release factor