U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

DET1 acid phosphatase DET1 [ Saccharomyces cerevisiae S288C ]

Gene ID: 851621, updated on 18-Sep-2024

Summary

Go to the top of the page Help
Official Symbol
DET1
Official Full Name
acid phosphatase DET1
Primary source
SGD:S000002458
Locus tag
YDR051C
See related
AllianceGenome:SGD:S000002458; FungiDB:YDR051C; VEuPathDB:YDR051C
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary
Enables acid phosphatase activity. Involved in dephosphorylation and intracellular sterol transport. Located in cytoplasm and nucleus. [provided by Alliance of Genome Resources, Apr 2022]
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
See DET1 in Genome Data Viewer
Location:
chromosome: IV
Exon count:
1
Sequence:
Chromosome: IV; NC_001136.10 (557056..558060, complement)

Chromosome IV - NC_001136.10Genomic Context describing neighboring genes Neighboring gene Vms1p Neighboring gene triose-phosphate isomerase TPI1 Neighboring gene protein serine/threonine kinase activating protein DBF4 Neighboring gene SCF E2 ubiquitin-protein ligase catalytic subunit CDC34

Genomic regions, transcripts, and products

Go to the top of the page Help
Genomic Sequence:
NC_001136.10

Go to nucleotide: Graphics FASTA GenBank

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. Identification of nucleases and phosphatases by direct biochemical screen of the Saccharomyces cerevisiae proteome. Ho CK, et al. PLoS One, 2009 Sep 15. PMID 19753119, Free PMC Article
  2. Phenotypic heterogeneity can enhance rare-cell survival in 'stress-sensitive' yeast populations. Bishop AL, et al. Mol Microbiol, 2007 Jan. PMID 17176259
  3. Tritium suicide selection identifies proteins involved in the uptake and intracellular transport of sterols in Saccharomyces cerevisiae. Sullivan DP, et al. Eukaryot Cell, 2009 Feb. PMID 19060182, Free PMC Article
  4. A yeast phenomic model for the gene interaction network modulating CFTR-ΔF508 protein biogenesis. Louie RJ, et al. Genome Med, 2012 Dec 27. PMID 23270647, Free PMC Article
  5. Mps1 Mediated Phosphorylation of Hsp90 Confers Renal Cell Carcinoma Sensitivity and Selectivity to Hsp90 Inhibitors. Woodford MR, et al. Cell Rep, 2016 Feb 2. PMID 26804907, Free PMC Article

See all (28) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. DET1 is involved in intracellular sterol transport.
    Title: Tritium suicide selection identifies proteins involved in the uptake and intracellular transport of sterols in Saccharomyces cerevisiae.
Submit: New GeneRIF Correction

Pathways from PubChem

Go to the top of the page

Interactions

Go to the top of the page Help
Products Interactant Other Gene Complex Source Pubs Description

General gene information

Go to the top of the page Help

Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables acid phosphatase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables catalytic activity IEA
Inferred from Electronic Annotation
more info
  
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
  
enables phosphatase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in intracellular sterol transport IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in intracellular sterol transport IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in lipid transport IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in cytoplasm HDA PubMed 
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in nucleus HDA PubMed 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  

General protein information

Go to the top of the page Help
Preferred Names
acid phosphatase DET1
NP_010336.3
  • Acid phosphatase; involved in the non-vesicular transport of sterols in both directions between the endoplasmic reticulum and plasma membrane; deletion confers sensitivity to nickel

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001136.10 Reference assembly

    Range
    557056..558060 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001180359.3 → NP_010336.3  TPA: acid phosphatase DET1 [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_010336.3

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6VS38, P87337, Q05314, Q7LHX4, Q99288
    UniProtKB/TrEMBL
    A6ZY17, B3LGL7, C7GT99, C8Z4X0, G2WAF6, N1P826
    Conserved Domains (1) summary
    pfam00300
    Location:27 → 321
    His_Phos_1; Histidine phosphatase superfamily (branch 1)
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q99288.1

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Other Literature Sources
Molecular Biology Databases
Research Materials
Tools